A5082249557- Nonmelanoma Skin Cancer Studies
- Cutaneous Melanoma Detection and Management
- Cancer and Skin Lesions
- Cutaneous lymphoproliferative disorders research
- Hedgehog Signaling Pathway Studies
- Immunotherapy and Immune Responses
- Genetic and rare skin diseases.
- Genital Health and Disease
- Dermatology and Skin Diseases
- CAR-T cell therapy research
- Dermatologic Treatments and Research
- Research on Leishmaniasis Studies
- Tumors and Oncological Cases
- Oral and Maxillofacial Pathology
- Sex and Gender in Healthcare
- Colorectal and Anal Carcinomas
- Mast cells and histamine
- Medicine and Dermatology Studies History
- Infectious Diseases and Mycology
- Autoimmune Bullous Skin Diseases
- Optical Coherence Tomography Applications
- Cervical Cancer and HPV Research
- Urticaria and Related Conditions
- Dermatological and Skeletal Disorders
- Ear and Head Tumors
University of Florence
2021-2025
Department of Medical Sciences
2024
To improve the diagnostic accuracy and optimal management of pediatric melanomas.We conducted a retrospective descriptive, multicenter study epidemiological, clinical, dermoscopic characteristics histopathologically proven melanomas diagnosed in patients less than 18 years old. Data on sociodemographic variables, clinical characteristics, histopathology, local extension, therapy follow-up, lymph node staging, outcome were collected from databases three Italian dermatology units. We performed...
Despite being early-stage tumors, thin cutaneous melanomas contribute significantly to mortality and have a rising incidence. A retrospective case–control study was performed identify clinical–dermoscopic histopathological variables linked local distant metastases in ≤0.8 mm. Data from 1 January 2000 22 June 2022 were analyzed two Italian skin cancer referral centers. Sixteen patients with mm developing studied compared controls without over 5 years. Statistical analysis involved Pearson’s...
Cutaneous and mucosal angiosarcoma (CMA) is a rare aggressive tumor of vascular endothelial cells that can occur in any body site, including the skin mucosa. A history radiation chronic lymphedema are well-established risk factors, but causes sporadic CMA less clear. Dermoscopy has emerged as useful noninvasive tool aid diagnosing cutaneous tumors, CMA, by providing magnified images surface subsurface structures. However, to date, little known about dermoscopic patterns CMA. This study aimed...
Abstract Background Porocarcinoma (PC) is a rare cutaneous adnexal tumor with variable metastatic potential. Given the paucity of data, guidelines and specific recommendations for PC are not yet well‐established. In this study, we evaluate disease‐specific characteristics outcome often underestimated tumor. Materials method A retrospective study epidemiological, clinical, dermoscopic among cases histopathologically diagnosed PC, collected from database two skin cancer clinics in Italy...
Despite recent progress and the publishing of several clinical guidelines on management advanced basal cell carcinoma, there is still no comprehensive set addressing complexity inherent to use Hedgehog pathway inhibitors in treatment carcinoma real-world practice. To develop practical valuable tools that help specialists improve these patients, we sought opinion expert physicians with extensive knowledge experience carcinoma.
Atypical Spitz tumours (ASTs) are regarded as an intermediate category distinguished from prototypical naevus by presenting one or more atypical features and often uncertain malignant potential. Clinical dermoscopic may play a relevant role in the diagnostic approach.To evaluate clinical of ASTs, their evolution over time.This was descriptive, multicentre study characteristics ASTs. Data on characteristics, histopathology, local extension, therapy follow-up, lymph node staging, complete...
Vulvar melanoma is considered rare, but it the second most frequent vulvar neoplasm; 2% of melanomas in women arise area. It important to highlight how characteristics differentiate from classic cutaneous melanoma. has different risk factors and clinical dermoscopic characteristics; moreover, a higher recurrence rate greater likelihood multifocality. Here, we present case 44-year-old patient with two primary located on opposite sides her vulva. The lesions were both flat, they had distinct...
Oral targeted therapy with hedgehog pathway inhibitors has revolutionized the standard of care for patients advanced basal cell carcinoma (BCC). These are frail and elderly, have various comorbidities, receive pharmacological polytherapy. Moreover, adverse events may a significant impact on therapeutic adherence, which must be managed by clinician. We evaluated caregivers treatment BCC in terms continuation over time. All included this observational prospective study had histologically...
Nevoid basal cell carcinoma syndrome (NBCCS, Gorlin syndrome) is a rare genetic condition characterized by the early development of numerous cutaneous carcinomas (BCCs). Although most BCCs are surgically treated with total resection, some lesions may proceed to locally advanced or metastatic stage. Systemic treatment hedgehog inhibitors (HHIs) such as Vismodegib Sonidegib indicated in this population. We report cases two patients confirmed diagnoses NBCCS. Both had undergone multiple...
Introduction: Vulvar intraepithelial neoplasia (VIN) is a vulvar skin lesion considered precursor of squamous cell carcinoma. No characteristics have been discovered to date that allows us differentiate between degrees VIN. Objectives: The aim this study was correlate the clinical and dermoscopic features VIN cases with histopathological findings. Methods: A prospective VINs recruited. Data on characteristics, histopathology, were collected from two Italian Dermatology Units January 2020...
Cutaneous immune-related adverse events (irAEs) occur in more than one-third of patients treated with immune checkpoint inhibitors; they are often the first clinical manifestation, although may months after initiation therapy. We noticed that our usually have these cutaneous AEs on photodamaged skin. In fact, out 19 being for metastatic melanoma, 8 (42%), all whom had significant actinic damage, developed irAEs earlier and a serious form those without such damage. Thus, we gave high oral...
A Sri Lankan man presents with the suspicion of chronic idiopathic urticaria angioedema, but facial swelling leads to an unexpected discovery. Thickened skin, nodules and neurological symptoms reveal true culprit. Leprosy challenges diagnosis in non-endemic regions. Vigilance comprehensive assessment are crucial unmask this great imitator.
Fluorescence-advanced videodermatoscopy (FAV) is a new non-invasive high-resolution skin imaging technique to assess pigmented lesions in conjunction with the clinical examination and dermatoscopy.This first prospective study identify morphologic descriptors standardized terminology examine facial using FAV. The objectives were FAV indicators, which can assist physicians diagnosing suspicious flat lesions.Consecutive equivocal retrospective analysed. Histopathological was performed for all...
Eruptive melanocytic nevi (EMN) describes the sudden onset of cutaneous over weeks or months. Such a clinical event is generally seen in young adult patients and may be related to several possible causes. We report here case EMN an old male patient followed up for thick amelanotic melanoma. A few months after eruption, multiple hepatic masses, diagnosed as melanoma metastasis, were detected. The presented suggest that paraneoplastic phenomenon alert being other malignancies.
We have read with great interest the paper by Kesić, V. et al. entitled “Early Diagnostics of Vulvar Intraepithelial Neoplasia” [...]
A case of recurrent lentigo maligna in a 45-year-old woman is presented. The disease relapsed several times following the surgical excision lesion. An alternative treatment with imiquimod 5% cream was then used. After 4 years follow-upfrom last surgery, this achieved total clearance problems diagnosis and are discussed.
Abstract Background Oral target therapy with hedgehog-pathway inhibitors has revolutionized the standard of care for patients advanced basal cell carcinoma. These are frail and elderly various comorbidities on pharmacological polytherapy. This scenario requires clinician to manage adverse events that can have a significant impact therapeutic adherence. Objectives We evaluated caregivers in treatment BCC under terms continuation over time. Methods All included this observational prospective...