A5080556061- Cardiac electrophysiology and arrhythmias
- Cardiovascular Effects of Exercise
- Cardiac pacing and defibrillation studies
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Cardiomyopathy and Myosin Studies
- Venous Thromboembolism Diagnosis and Management
- Ion channel regulation and function
- Genetics and Physical Performance
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac tumors and thrombi
- Viral Infections and Immunology Research
- Cardiovascular Function and Risk Factors
- Pharmaceutical studies and practices
- ECG Monitoring and Analysis
- Poisoning and overdose treatments
- RNA regulation and disease
- Congenital Heart Disease Studies
- Sports injuries and prevention
- Child Nutrition and Water Access
- Genomics and Rare Diseases
- Medication Adherence and Compliance
- Pharmaceutical industry and healthcare
- Electrostatic Discharge in Electronics
- Drug-Induced Ocular Toxicity
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2018-2024
Universidade de São Paulo
2014-2024
Hospital do Coração
2022-2024
Instituto do Coração
2023
Laboratory of Molecular Genetics
2023
Denso (United States)
2022
Istituti Clinici Scientifici Maugeri
2020
Abstract Aims High precordial leads (HPL) on the resting electrocardiogram (ECG) are widely used to improve diagnostic detection of type 1 Brugada ECG pattern (Br1ECGp). A parasympathetic activation marks initial recovery phase treadmill stress testing (TET), and this can be useful for detecting typical pattern. Our study aimed evaluate role a new HPL-treadmill exercise (TET) protocol in Br1ECGp fluctuation compared HPL-ECG. Methods results 74 out 163 patients syndrome (BrS) Brazilian cohort...
Introduction: The echocardiographic diagnosis criteria for arrhythmogenic right ventricular cardiomyopathy (ARVC) are highly specific but sensitivity is low, especially in the early stages of disease. role strain ARVC has not been fully elucidated, although prior studies suggest that it can improve detection subtle functional abnormalities. purposes study were to determine whether these advanced measures (RV) dysfunction on echocardiogram, including RV strain, increase diagnostic value...
A Filamina C (FLNC) desempenha um papel crítico na manutenção da integridade estrutural das células musculares, particularmente dentro do sarcômero cardíaco. Variantes patogênicas no gene FLNC são cada vez mais reconhecidas como contribuintes significativos para uma gama diversificada de cardiomiopatias, incluindo cardiomiopatia dilatada (CMD), hipertrófica (CMH), arritmogênica (CMA) e restritiva (CMR). Esta revisão explora as correlações genótipo-fenótipo em cardiomiopatias relacionadas ao...
Thromboembolic events are associated with high mortality and morbidity indexes. In this context, warfarin is the most widely prescribed oral anticoagulant agent for preventing treating these events. This medication has a narrow therapeutic range and, consequently, patients usually have difficulty in achieving maintaining stable target therapeutics. Some studies on literature about management showed that pharmacists could improve efficiency of therapy. However, majority included general...
Mutations in the Lamin A/C(LMNA) gene are commonly associated with cardiac manifestations, such as dilated cardiomyopathy (DCM) and conduction system disease. However, overall spectrum penetrance of rare LMNA variants unknown. The present study described presence LMNAvariants patients "lone atrial fibrillation (AF)" their sole clinical presentation.One-hundred one consecutive AF" criteria were initially screened by genetic testing. Genetic classified according to American College Genomic...
Cardiomyopathy is characterized by structural and functional abnormalities in the heart muscle that are not influenced coronary disease, hypertension, valve or congenital defects. Genetic testing, which helps diagnose molecular bases of cardiomyopathy, can affect prognostication clinical decisions. Recent guidelines advocate classifying cardiomyopathies based on phenotypic categories, encompass a range presentations, underlying causes, outcomes. Beyond deepening our grasp genetic testing...
Arrhythmogenic right ventricular cardiomyopathy (ARVC), a rare inherited disease, causes tachycardia, sudden cardiac death, and heart failure (HF). We investigated ARVC clinical features, genetic findings, natural history, the occurrence of life-threatening arrhythmic events (LTAEs), HF or transplantation (HF-death/HTx) to identify risk factors.The course 111 consecutive patients with definite ARVC, predictors LTAE, HF-death/HTx, combined were analyzed in entire cohort subgroup 40 without...
Brugada syndrome (BrS) has diagnostic challenges and controversial risk assessment. We aimed to investigate invasive noninvasive parameters in symptomatic asymptomatic patients from a Brazilian cohort of type-1 BrS.Patients with spontaneous drug-induced BrS were classified into two groups, (n = 116, 84.1%) 22, 15.9%; 13 arrhythmogenic syncope, 9 aborted sudden cardiac death). Genetic testing, EPS parameters, electrocardiogram (ECG) analyzed.A total 138 consecutive eligible, 101 men (73.2%),...
Background Brugada syndrome and long-QT may account for at least one third of unexplained sudden cardiac deaths. Dental care in patients with channelopathies is challenging because the potential risk life-threatening events. We hypothesized that use local dental anesthesia lidocaine without epinephrine safe does not result arrhythmias channelopathies. Methods Results performed a randomized, double-blind pilot trial comparing 2% vasoconstrictor 1:100 000 2 sessions restorative treatment...
Resumo Os testes genéticos para cardiomiopatia dilatada (CMD) apresentam uma positividade de até 40%, mas há grande heterogeneidade genética e outros desafios decorrentes expressividade variável penetrância incompleta. O heredograma é fundamental diferenciar os casos CMD esporádica familiar, por meio da avaliação do histórico familiar. A familiar apresenta um rendimento maior nos genéticos, a não exclui possibilidade causa genética. Alguns genes têm fenótipos específicos, sendo o gene [...]
Background: Warfarin is the most commonly drug for oral anticoagulant therapy, especially in low-income and emerging countries, because of high cost direct (DOACs) or when warfarin only proven therapy (mechanical prosthetic valve kidney dysfunction). The beneficial outcomes are directly dependent on quality anticoagulation management dose regimen. Studies showed that pharmacists could improve effectiveness with warfarin. However, there no studies showing this intervention a specific patient...
Background Dental anesthetic management in implantable cardioverter defibrillator (ICD) recipients with cardiac channelopathies (CCh) can be challenging due to the potential risk of life-threatening arrhythmias and appropriate ICD therapies during procedural time. Objectives The present study assessed hypothesis that use local dental anesthesia 2% lidocaine 1:100,000 epinephrine or without a vasoconstrictor safe selected CCh patients, not resulting events (LTE). Methods Restorative treatment...
Resumo Fundamento No tratamento da fibrilação atrial (FA), a arritmia sustentada mais frequente, com ablação por cateter (ABL) ou cardioversão elétrica (CVE), o período periprocedimento é uma das fases críticas. Atualmente, uso de novos anticoagulantes orais ação direta (DOAC) cada vez no entanto, mundo real, ainda existem poucos dados estudos sobre incidência trombo átrio esquerdo (TrAE) contraste espontâneo denso (CE) ecocardiograma transesofágico (ETE). Objetivo Analisar prevalência [...]
Patient MSV, a 61-year-old woman born in Penteado, Alagoas, Brazil and residing Sao Paulo was hospitalized for decompensated heart failure (HF). Approximately 1 year before, she experienced dyspnea with moderate effort, there marked worsening over the last 3 months associated orthopnea lower limb edema. Laboratory tests from when patient first seen at InCor emergency unit (in March 2013) revealed: 3.3 million red blood cells/mm³; hemoglobin 10.9 g/dL; hemocyte 33%; MCV (mean...