A5020051445- Diabetes and associated disorders
- Diabetes Management and Research
- Pancreatic function and diabetes
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Ion channel regulation and function
- Cardiac Ischemia and Reperfusion
- Diet and metabolism studies
- Adenosine and Purinergic Signaling
- Metabolism, Diabetes, and Cancer
- Diabetes Treatment and Management
- Heart Rate Variability and Autonomic Control
- Birth, Development, and Health
- Diabetes Management and Education
- Global Public Health Policies and Epidemiology
- Diet, Metabolism, and Disease
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Disease and Adiposity
- Oral Health Pathology and Treatment
- Liver Disease Diagnosis and Treatment
- Chronic Disease Management Strategies
- Alcohol Consumption and Health Effects
- Receptor Mechanisms and Signaling
- Vitamin D Research Studies
- Adipose Tissue and Metabolism
- Cardiac Imaging and Diagnostics
Albert Einstein College of Medicine
2017-2024
Université de Yaoundé I
2013-2021
Yeshiva University
2021
Usmanu Danfodiyo University
2020
The Bronx Defenders
2018
Délégation Paris 7
2014
Université Paris Cité
2014
OBJECTIVE Diabetes among individuals with low BMI (<19 kg/m2) has been recognized for >60 years as a prevalent entity in low- and middle-income countries (LMICs) was formally classified “malnutrition-related diabetes mellitus” by the World Health Organization (WHO) 1985. Since WHO withdrew this category 1999, our objective to define metabolic characteristics of these establish that is distinct form diabetes. RESEARCH DESIGN AND METHODS State-of-the-art studies were used...
There is a burglar association between diabetes and periodontitis. Many studies has shown that periodontitis treatment can help improving glycemic control in patients but little evidence of non-surgical benefit available sub Saharan african patients. We aimed to assess the effects periodontal (NSPT) chronic on glycaemic poorly controlled type 2 (T2D) sub-Saharan Africa urban setting. A total 34 T2D with aged 51.4 ± 8.8 years (mean SD), known duration 55.5 42.6 months, HbA1c 9.3 1.3% were...
Pesticide exposure may induce biochemical alterations including oxidative stress and lipid peroxidation. However, in the context of developmental origin health disease, putative trans-generational effect to pesticides are insufficiently studied. We therefore aimed evaluate gestational four on female Wistar rats their offspring at adult age. studied 30 nulliparous divided into 5 equal groups. Group 1 served as control group received distilled water while 2, 3, 4 orally pesticide...
Adipose tissue inflammation and fibrosis appear to contribute insulin resistance in obesity. Vitamin D receptor (Vdr) genes are expressed by adipocytes, macrophages, fibroblasts, all of which could potentially play a role adipose fibrosis. As vitamin has been shown have direct anti-inflammatory effects on we determined whether specific receptor-mediated adipocytes impact ultimately resistance. We examined the repleting 25(OH)D-deficient, resistant, overweight-to-obese human subjects (n =...
Hyperglycemia is a potent regulator of endogenous glucose production (EGP). Loss this “glucose effectiveness” major contributor to elevated plasma concentrations in type 2 diabetes (T2D). KATP channels the central nervous system have been shown regulate EGP humans and rodents. We examined contribution effectiveness. Under fixed hormonal conditions (studies using pancreatic clamp), hyperglycemia suppressed by ∼50% both without normal Sprague-Dawley rats. By contrast, antagonism with glyburide...
It is unclear whether ketosis-prone diabetes a specific type or subtype of Type 2 diabetes. We aimed to describe the clinical and metabolic features in sub-Saharan population.We consecutively enrolled characterized 173 people with non-autoimmune admitted for hyperglycaemic crisis at Yaoundé Central Hospital, Cameroon. Blood samples were collected fasting glucose, HbA1c , lipid profile C-peptide assays insulin resistance secretion estimation by homeostasis model assessment. People classified...
Although intensive glycemic control improves outcomes in type 1 diabetes mellitus (T1DM), iatrogenic hypoglycemia limits its attainment. Recurrent and/or antecedent causes blunting of protective counterregulatory responses, known as hypoglycemia-associated autonomic failure (HAAF). To determine whether and how opioid receptor activation induces HAAF humans, 12 healthy subjects without (7 men, age 32.3 ± 2.2 years, BMI 25.1 1.0 kg/m2) participated two study protocols random order over...
Abstract Context Hypoglycemia-associated autonomic failure (HAAF), defined as blunting of counterregulatory hormone and symptom responses to recurrent hypoglycemia, remains a therapeutic challenge in diabetes treatment. The opioid system may play role HAAF pathogenesis since activation receptors induces HAAF. Blockade with intravenous naloxone ameliorates experimentally yet is not feasible therapeutically. Objective To investigate the effects receptor blockade intranasal on induced Design...
Diabetes is a growing health concern in developing countries, with Cameroon population having an estimated 6% affected. Of note, hospital attendees appear to be increasing all over the country, fluctuating numbers throughout annual calendar. The aim of study was investigate relationship between diabete hospitalization admission rates and climate variations Yaounde.A retrospectively designed conducted four facilities Yaounde (Central Hospital, University teaching hospital, Biyem-Assi...
To assess the effect of free diabetes care on metabolic control and health-related quality life (HRQoL) youths living with type 1 in Cameroon.We conducted a clinical audit multicenter prospective cohort, performed three nine clinics 'Changing Diabetes Children' (CDiC) project Cameroon. We collected data demography, glycemic control, acute complications, patients' HRQoL at baseline after year follow-up.One hundred four patients (51 female) were included. The mean age was 16±2 years (min-max:...
Abstract Background Recurrent hypoglycemia blunts counter-regulatory responses to subsequent hypoglycemic episodes, a syndrome known as hypoglycemia-associated autonomic failure (HAAF). Since adrenergic receptor blockade has been reported prevent HAAF, we investigated whether the rise in plasma epinephrine contributes pathophysiology and interindividual differences susceptibility HAAF. Methods To assess role of 24 adult nondiabetic subjects underwent two 2-hour hyperinsulinemic clamp studies...
We aimed to evaluate the predictive utility of common fasting insulin sensitivity indices, and non-laboratory surrogates [BMI, waist circumference (WC) waist-to-height ratio (WHtR)] in sub-Saharan Africans without diabetes. measured glucose insulin, uptake during 80/mU/m2/min euglycemic clamp 87 Cameroonians (51 men) aged (SD) 34.6 (11.4) years. derived indices including HOMA-IR, quantitative check index (QUICKI), resistance (FIRI) glucose-to-insulin (GIR). Indices clinical predictors were...
Background: Quail eggs as a food item have recently been introduced into the diet of some Cameroonians. These are being sold in local markets, but with many unfounded health claims. One claim is that quail can reduce blood glucose levels diabetics. It was therefore necessary to evaluate effect consuming on levels, lipid profiles, and oxidative stress parameters diabetes-induced rats.Methods: Twenty Wistar rats weighing, average, 250 g were divided four groups five each. Group 1 consisted...
Viruses have been considered potential triggers for the development of diabetes. This study assessed insulin secretion and sensitivity in human herpesvirus 8 (HHV8)-infected uninfected sub-Saharan African people with diabetes.In all, 173 non-autoimmune diabetes were enrolled consecutively: 124 type 2 mellitus (T2DM) 49 ketosis-prone (KPD) admitted hyperglycemic crisis. Those KPD further subdivided into those new-onset ketotic-phase (n = 34) or non-ketotic phase 15). All participants screened...