A5102708243- Olfactory and Sensory Function Studies
- CAR-T cell therapy research
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Advanced Chemical Sensor Technologies
- Biochemical Analysis and Sensing Techniques
- Multiple Myeloma Research and Treatments
- Essential Oils and Antimicrobial Activity
- Fermentation and Sensory Analysis
- Neurobiology and Insect Physiology Research
- Plant and animal studies
- Chronic Lymphocytic Leukemia Research
University Hospital Leipzig
2023-2025
Leibniz-Institute for Food Systems Biology at the Technical University of Munich
2021-2024
Furanones formed during the Maillard reaction often are natural aroma-determining compounds found in numerous foods. Prominent economically relevant representatives structural homologues Furaneol and sotolone, which important flavoring because of their distinct caramel- seasoning-like odor qualities. These, however, cannot be predicted by odorants' molecular shape, rather receptors' activation parameters help to decipher encoding quality. Here, qualities sotolone suggested an at least two...
<title>Abstract</title> Chimeric Antigen Receptor (CAR) T-cell therapies targeting B-cell maturation antigen (BCMA) have transformed the treatment landscape for relapsed/refractory multiple myeloma (RRMM). In this study, we present a real world cohort of 61 RRMM patients treated with idecabtagene vicleucel (Ide-cel, n=34) and ciltacabtagene autoleucel (Cilta-cel, n=27). Cilta-cel demonstrated superior complete response (CR) rates (CR: 78% vs. 38%, p < 0.001) longer progression-free...
4-Methylphenol is a food-related odor-active volatile with high recognition factor, due to its horse stable-like, fecal odor quality. Its ambivalent hedonic impact as key aroma compound, malodor, and semiochemical has spurred the search for cognate, chemosensory odorant receptors across species. A human receptor highly characteristic 4-methylphenol been elusive. Here, we identified characterized OR9Q2 be tuned purified 4-methylphenol, but not contaminant isomer 3-methylphenol. This selective...
Geosmin, a ubiquitous volatile sesquiterpenoid of microbiological origin, is causative for deteriorating the quality many foods, beverages, and drinking water, by eliciting an undesirable "earthy/musty" off-flavor. Moreover, across species from worm to human, geosmin volatile, chemosensory trigger both avoidance attraction behaviors, suggesting its role as semiochemical. Volatiles typically are detected receptors nose, which have evolved best detect ecologically relevant food-related...
Grapevine (Vitis vinifera) is one of the most important perennial fruit plants. The variety Riesling stands out by developing a characteristic petrol-like odor note during aging, elicited aroma compound 1,1,6-trimethyl-1,2-dihydronaphthalene (TDN). UV-dependent TDN contents differ largely among Rieslings grown in northern versus southern hemisphere. Highest concentrations were found Australian Rieslings, where scoring ingredient. In contrast, from Europe, for example, may be tending cause...