A5023402350- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Treatments and Studies
- Anatomy and Medical Technology
- Anorectal Disease Treatments and Outcomes
- Immune Cell Function and Interaction
- Immune cells in cancer
- Colorectal Cancer Surgical Treatments
- Multiple and Secondary Primary Cancers
- Gastric Cancer Management and Outcomes
- Cancer Genomics and Diagnostics
- Gastrointestinal Tumor Research and Treatment
Peking University
2022-2025
Peking University Cancer Hospital
2022-2025
Surgical excision is currently the principal therapy for locoregional colorectal cancer (CRC). However, surgical trauma leads to controlled tissue damage, causing profound alterations in host immunity and, turn, affecting post-operative outcomes. Surgery-induced immune CRC remain poorly defined. Here, single-cell mass cytometry was applied serial blood samples collected pre-operatively, and on days 1, 3, 7 post-operatively from 24 patients who underwent laparoscopic resection of...
Anastomotic leakage (AL) is a serious complication that may occur following the double stapling technique (DST). The study aims to investigate efficacy of anastomotic reinforcement using barbed sutures in preventing AL after laparoscopic low anterior resection (LAR) for rectal cancer. During period from November 1, 2018 2023, total 725 consecutive patients who had underwent LAR cancer were enrolled this study. divided into two groups: continuous suture group (N = 296) and control 429)....
Patients with stage II colorectal cancer (CRC) show considerable variability in prognosis. Circulating immune cells play a vital role systemic tumor surveillance. This study aimed to determine the clinical significance of frequency and phenotype circulating cell subsets patients CRC. We applied 37-marker-cell-lineage-agnostic panel perform single-cell mass cytometry on peripheral blood mononuclear (PBMCs) from 73 CRC 21 III To categorize into consensus molecular subtypes (CMS), we performed...