A5018260007- Vasculitis and related conditions
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Otitis Media and Relapsing Polychondritis
- Inflammasome and immune disorders
- Renal Diseases and Glomerulopathies
- Systemic Sclerosis and Related Diseases
- Kawasaki Disease and Coronary Complications
- Urticaria and Related Conditions
- Sarcoidosis and Beryllium Toxicity Research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Systemic Lupus Erythematosus Research
- Gastroesophageal reflux and treatments
- Helicobacter pylori-related gastroenterology studies
- Aortic aneurysm repair treatments
- Autoimmune Bullous Skin Diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cell Adhesion Molecules Research
- Eosinophilic Disorders and Syndromes
- interferon and immune responses
- Heparin-Induced Thrombocytopenia and Thrombosis
- Aortic Disease and Treatment Approaches
- Gastric Cancer Management and Outcomes
- Aortic Thrombus and Embolism
- Vascular Anomalies and Treatments
- Dermatologic Treatments and Research
Hôpital Tenon
2021-2025
Sorbonne Université
2021-2025
Assistance Publique – Hôpitaux de Paris
2021-2025
Centre Hospitalier Universitaire de Caen Normandie
2017-2024
Université de Caen Normandie
2017-2024
Centre Hospitalier Universitaire de Nice
2018-2024
Normandie Université
2019-2023
Centre de Référence des Maladies Autoinflammatoires et des Amyloses
2021
Objective A new adult-onset autoinflammatory syndrome has been described, named VEXAS (Vacuoles, E1 Enzyme, X-linked, Autoinflammatory, Somatic). We aimed to compare the clinical characteristics, laboratory features and outcomes between idiopathic-relapsing polychondritis (I-RP) VEXAS-relapsing (VEXAS-RP). Methods Patients from French retrospective multicentre cohort of RP were separated into two groups: a VEXAS-RP an I-RP. Results Compared with patients I-RP (n=40), (n=55) men (96% vs 30%,...
Vacuoles, E1 enzyme, X-linked, autoinflammatory and somatic (VEXAS) syndrome is an adult-onset disease associated with ubiquitin-like modifier-activating enzyme 1 (UBA1) mutations. We aimed to evaluate the efficacy safety of targeted therapies.
Objective. To identify characteristics and factors associated with relapse glucocorticoid (GC) dependence in patients giant cell arteritis (GCA). Methods. We retrospectively analyzed 326 consecutive GCA followed for at least 12 months. Factors GC were identified multivariable analyses. Results. The (73% women) up 62 (12–262) During followup, 171 (52%) relapsed, including 113 (35%) who developed dependence. Relapsing had less history of stroke (p = 0.01) presented large-vessel vasculitis...
To describe the impact of cumulative glucocorticoid (GC) doses on related adverse events (AEs) in giant cell arteritis (GCA) a real-life setting.The medical charts last 139 consecutive GCA patients followed tertiary centre were retrospectively analysed. The GC calculated, and main GC-related AEs collected during follow-up.After median follow-up duration 35.6 (2-111) months, dose was 9184 (1770-24,640) mg, 131 (94%) presented at least one AE. Infections (63%) most frequently reported AE, by...
Secondary to tumour necrosis factor-alpha induced protein 3 (TNFAIP3) mutations, A20 haploinsufficiency (HA20) is a recently described autoinflammatory disease with clinical features similar those of Behçet's and Crohn's diseases but constantly expanding spectrum. Here, we describe HA20 liver involvement in three new patients from the same family. We retrospectively assessed clinical, biological and/or histological findings for eight over generations family heterozygous mutations TNFAIP3...
The literature supporting the role of a specific drug in onset drug-induced antineutrophil cytoplasmic antibody-associated vasculitis (AAV) mainly relies on case reports or short series and implicates old treatments. advent new treatments may have modified epidemiology these adverse reactions. This study was undertaken to update list drugs associated with AAV by using pharmacovigilance-based data mining approach.We collected reactions reported Medical Dictionary for Regulatory Activities...
Abstract Objectives To assess the frequency and characteristics of severe relapse in patients with GCA a real-life setting. Methods In monocentric database 530 patients, we retrospectively analysed who experienced at least one distinguished from non-severe relapses. Severe was defined by occurrence an ischaemic event (ophthalmologic, neurologic, digestive, limb ischaemia), aortic complication (i.e. new or worsening dilation, dissection), vascular stenosis. Results From cohort 242 (45.7%)...
To describe, in a real-life setting, the direct causes of death cohort consecutive patients with GCA.We retrospectively analysed deaths that occurred 470 GCA from centre expertise between January 2000 and December 2019. Among 120 who died, we retrieved data medical files 101 patients.Cardiovascular events were dominant cause (n = 41, 41%) followed by infections 22, 22%), geriatric situations (i.e. falls or senile deterioration; n 17, 17%) cancers 15, 15%). Patients each these four groups...
To assess patients' self-reported glucocorticoid (GC)-related adverse events (AEs) in a GCA population.
We report a case of the endoscopic discovery and removal specimen Necator americanus hooked into gastric mucosa black woman from Zaire. extracted parasite by means biopsy forceps. Signs previous bites were seen in antrum. This exceptional localization might be due to jejuno-duodeno-gastric reflux.