A5028784002- Vasculitis and related conditions
- Systemic Lupus Erythematosus Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Urticaria and Related Conditions
- Cell Adhesion Molecules Research
- Atherosclerosis and Cardiovascular Diseases
- Otitis Media and Relapsing Polychondritis
- Hematological disorders and diagnostics
- Salivary Gland Disorders and Functions
- Systemic Sclerosis and Related Diseases
- Retinal and Optic Conditions
- Adrenal Hormones and Disorders
- Intraoperative Neuromonitoring and Anesthetic Effects
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Salivary Gland Tumors Diagnosis and Treatment
- Sarcoidosis and Beryllium Toxicity Research
- Viral Infections and Vectors
- Thermal Regulation in Medicine
- Streptococcal Infections and Treatments
- Autoimmune and Inflammatory Disorders Research
- Myasthenia Gravis and Thymoma
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cerebrovascular and genetic disorders
- Immune Cell Function and Interaction
- Hormonal Regulation and Hypertension
Hôpital Dupuytren
2012-2025
Université de Limoges
2013-2024
Hôpital Universitaire Dupuytren
2013-2022
Centre Hospitalier Universitaire de Limoges
2017-2021
Giant cell arteritis (GCA) is a chronic systemic vasculitis of large and medium-sized arteries, for which long-term glucocorticoid (GC) treatment needed. During GC withdrawal patients can suffer adrenal insufficiency. We sought to determine the time until recovery function after therapy, assess prevalence predictors secondary insufficiency.150 meeting ACR criteria GCA between 1984 2012 were analyzed. All received same protocol. The low-dose ACTH stimulation test was repeated annually...
Objective To identify the key coding genes underlying biomarkers and pathways associated with giant cell arteritis (GCA), we performed an in situ spatial profiling of molecules involved temporal arteries GCA patients controls. Furthermore, pharmacogenomic network analysis to potential treatment targets. Methods Using human formalin-fixed paraffin-embedded artery biopsy samples (GCA, n = 9; controls, 7), a whole transcriptome using NanoString GeoMx Digital Spatial Profiler. In total, 59...
Fluorodesoxyglucose Positron Emission Tomography (PET/CT) has never been compared to Chest-Abdomen-Pelvis CT (CAPCT) in patients with a fever of unknown origin (FUO), inflammation (IUO) and episodic (EFUO) through prospective multicentre study. In this study, we investigated the diagnostic value PET/CT CAPCT these patients. The trial was performed between 1 May 2008 28 February 2013 7 French University Hospital centres. Patients who fulfilled FUO, IUO or EFUO criteria were included....
Abstract Objectives To describe patients who underwent a temporal artery biopsy (TAB) for suspected Giant Cell Arteritis (GCA) but were given different diagnosis. We focused on subset of alternate diagnoses mimicking GCA with ominous consequences delayed diagnosis or undue glucocorticoid treatment. Methods This was single-center retrospective study. All (n = 579) TAB initially and recruited from 2005 to 2023. Four groups defined: positive 248); negative 135); rapid alternative without (usual...
<b><i>Background:</i></b> Complementary and alternative medicine (CAM) is composed of a wide range interventions frequently used in parallel with conventional medicine. The aim this study was to assess the prevalence, modalities, association factors CAM utilization patients treated for systemic lupus erythematosus, primary Sjögren’s syndrome, or sclerosis. <b><i>Patients Methods:</i></b> This prospective single-center observational conducted...
Recurrent FUO (fever of unknown origin) is a rare subtype for which diagnostic procedures are ill-defined and outcome data lacking.
Neurotrophins play a central role in the development and maintenance of nervous system. However, neurotrophins can also modulate B T cell proliferation activation, especially via autocrine loops. We hypothesized that both serum lymphocytic neurotrophin levels may be deregulated systemic Lupus erythematosus (SLE) reflect clinical symptoms disease.Neurotrophins (ELISA tests) lymphocytes (flow cytometry) were measured 26 SLE patients control subjects. Th1 (interferon-γ) Th2 (IL-10) profiles...
Abdominal symptoms in patients with primary Sjögren syndrome (pSS) are poorly documented. The objective of the study was to describe abdominal pSS and assess their association characteristics disease.One hundred fifty were evaluated using a composite global symptom score for severity. Data concerning clinical biological disorders also collected.Of pSS, 95% suffered from (median 7.5 ± 5.5 points out 30). More than half experienced tension (68%), upper pain (54%), discomfort (58%) and/or...
Objectives: Giant cell arteritis (GCA) is a chronic systemic vasculitis of large and medium-sized arteries, for which long-term glucocorticoid (GC) treatment needed.During GC withdrawal patients can suffer adrenal insufficiency.We sought to determine the time until recovery function after therapy, assess prevalence predictors secondary insufficiency.Subjects Design: 150 meeting ACR criteria GCA between 1984 2012 were analyzed.All received same protocol.The low-dose ACTH stimulation test was...
While the diagnosis of adult-onset Still’s disease (AOSD) involves exclusion differential diagnoses, characteristics and value 18F-Fluorodeoxyglucose (18F-FDG) Positron Emission Tomography coupled with CT (PET/CT) in management AOSD remain poorly known. Our retrospective study included patients from four centers, fulfilling Yamaguchi or Fautrel criteria, who underwent a PET/CT during an active AOSD. Thirty-five were included. At time PET/CT, criteria met 23 29 evaluable cases. showed bone...