Background: To assess persistence rates of biologic agents for the treatment rheumatoid arthritis in Japan. Methods: Based on Japanese claims data 16,214 patients between 2012 and 2014, 6-, 12-, 18-month different were calculated. Determinants assessed by means a multivariate Cox proportional hazard model controlling age, sex, comorbidities. A sensitivity analysis was performed with definitions parametric survival analysis. Results: Overall Japan are high reach 86% after 1 year entire...

Biological therapies (BTs) including infliximab (IFX), adalimumab (ADL), secukinumab (SCK) and ustekinumab (UST) are approved in Japan for the treatment of psoriasis. Although persistence rates medical costs BTs have been investigated multiple foreign studies recent years, few such conducted differences between patients who adhered to those did not reported. This study is aimed at investigating psoriasis Japan, using real-world data from a large-scale claims database. Claims JMDC database...

Major depressive disorders (MDDs) including treatment-resistant depression (TRD) are common disabling conditions, but data on their epidemiology in Japan limited. This study investigated the incidence, epidemiology, and direct medical costs of TRD pharmaceutically-treated (PTD) to increase our health economic understanding this phenotype MDD.

An increasing emphasis on patient-centred health care and shared decision making requires an intensive consideration of patient preferences. In the present study, preferences regarding treatment HIV/AIDS were explored using direct assessment discrete choice experiment (DCE). Based literature research about patients we conducted a qualitative pre-study. The results used to compose questionnaire relevant aspects which underwent pre-test. subsequent quantitative study phase presented here,...

To determine the prevalence of depression among Japanese people with rheumatoid arthritis (RA) and explore relationships between an array variables. Nation-wide, cross-sectional online survey (n = 500) RA including Patient Health Questionnaire (PHQ-9) to measure presence severity depressive symptoms were performed. While only 5% population studied had been officially diagnosed depression, 35% PHQ-9 scores indicating was present. People are more likely experience if they younger, have greater...

Health-care utilities differ considerably from country to country. Our objective was examine the association of cultural values based on Hofstede's dimensions' theory with utility that were identified using time trade off method. We performed a literature search determine preference-based value algorithms in general population given then fitted second-order quadratic function assess curve links health status health-care utilities. ranked countries according concavity and convexity properties...

Osteoporotic fractures impose a huge economic burden on society. Though several cost of illness studies from other countries exist, no equivalent study has been conducted in Austria. Our aims at assessing costs resulting osteoporotic Austria the year 2008 societal perspective. We took both direct and indirect into consideration. Direct encompass medical such as expenses for pharmaceuticals, inpatient outpatient care costs, well services (e.g., occupational therapies). Non-medical include...

Many European countries regulate the markets for prescription drugs in order to cope with rising health expenditures. On other hand, regulation distorts incentives invest pharmaceutical R&D. This study aims at empirically assessing impact of on R&D We analyze a sample 20 leading companies between 2000 and 2008. The share sales Europe serves as proxy degree regulation. control firm specific determinants such cash flow, company size, leverage ratio, growth rate, Tobin's q. Our results suggest...

This article adds the Japanese perspective to our knowledge of shared decision-making (SDM) preferences by surveying patients with prostate cancer (PCA) and physicians in Japan. In 2015, 103 PCA were asked about their SDM using an Internet-based 5-point-scale questionnaire. Concurrently, 127 surveyed regarding perceptions patient on SDM. Drivers analyzed univariable ordinal logistic regression graphing fitted response probabilities. Although 41% both expressed expected a desire for active...

Background: This study sought to identify factors that impact the total health care costs associated with hospitalization of young Japanese children respiratory syncytial virus (RSV). Methods: Children admitted between April 2014 and March 2015 at least a confirmed diagnosis RSV 2 days hospital stay were considered for inclusion. Data analyses claims performed using structural equation modeling approach. Results: A 6811 inpatients (<5 years old) diagnosed included. The average length was 7.5...

Patient characteristics require consideration for optimal treatment in order to achieve clinical remission an improved quality of life and social functioning. Prior evidence supports long-acting injectable antipsychotics (LAIs) the relapse prevention schizophrenia. This study aimed characterize Japanese patients diagnosed with schizophrenia compare outcomes LAIs oral (AP) re-hospitalization or emergency room visit rates.Diagnostic Procedure Combination (DPC) designated hospital data Japan...

We have developed a new framework to assess shared decision-making (SDM) as tool improve patient satisfaction. This is based on "preference fit" index that relates SDM treatment preferences and satisfaction in sample of rheumatoid arthritis (RA) patients Japan. surveyed 500 RA Japan explored the interactions between preference fit index, SDM, overall Our reveals significant impact satisfaction: better preferences, higher with current treatment. Patients treated biologic agents were more...

The present study on people living with HIV/AIDS (PLWHA) identifies socio-demographic and health-related factors corresponding their labour market participation. sample bases a German observational sub-study of 527 male PLWHA. analysis is restricted to PLWHA in working age. By means multivariate regression, we identify that contribute unemployment job loss. probability be unemployed significantly negatively correlated age above 40 years graduation from university positively problems daily...

The objective of this study was (1) to determine productivity costs due absenteeism and presenteeism among Japanese workers with rheumatoid arthritis (RA), (2) identify additional factors associated loss RA.An online survey 500 RA patients used. version the Stanford Health Assessment Questionnaire (J-HAQ) used measure patients' functional disability. patient health questionnaire-9 item (PHQ-9) symptoms severity depression. To assess work 'work activity impairment questionnaire' for...

To describe the usage of different biologic agents for rheumatoid arthritis (RA) in Japan over time and to identify factors that affects decision initiate treatment with agents. Determinants a switch another agent patients who are already on were also analyzed.We utilized hospital claims database containing 36,504 Japanese confirmed RA diagnosis. analyze determinants choices, we applied logistic regression analysis taking into account socio-demographic medical factors.Analyses determined...

The aim of this study is to analyze if there a relationship between adherence antipsychotic medication and rehospitalization for patients diagnosed with schizophrenia in Japan.Based on Japanese claims data, we constructed three patient groups based their possession ratio (MPR). Controlling potential confounders, Cox proportional hazard model was employed assess affects the risk rehospitalization.Patients good (MPRs from 0.8-1.1) had lowest rates admission. Both poor <0.8) overadherence >1.1)...

To investigate drug survival for biologic disease-modifying antirheumatic drugs (bDMARDs) in a real-world cohort of German adult biologic-naïve patients with psoriatic arthritis (PsA). Claims data diagnosis PsA, bDMARD claims record (index date) between 1 January 2014 and 31 December 2017, no prescription 365 days before the index date were retrospectively analyzed. The primary outcomes overall individual persistence rates over 12 months. Nonpersistence was defined as treatment gap exceeding...

The approval of direct-acting antivirals for Interferon-free treatment revolutionized the therapy chronic Hepatitis C infection. As August 2014, two regimens genotype 1 infection received conditional in European Union: Sofosbuvir and Ribavirin 24 weeks Simeprevir with or without 12 weeks. We aim to analyze cost-effectiveness both Germany. set up a Markov model lifetime horizon simulate immediate success long-term disease progression treatment-naive patients. analyzes short-term costs...

With progress being made in the treatment of psoriasis, a variety clinical research and options are pursued. This study used discrete choice experiment (DCE) to estimate characteristic preferences for both patients physicians Japan. Subgroup analysis was also applied order examine differences within range physicians.The DCE developed with input experts psoriasis ensure inclusion most relevant attributes at appropriate levels way that is understandable patients. The conducted on parallel...