A5103639640- Asthma and respiratory diseases
- Sarcoidosis and Beryllium Toxicity Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Medical Imaging and Pathology Studies
- Neonatal Respiratory Health Research
- Pharmaceutical studies and practices
- Pneumocystis jirovecii pneumonia detection and treatment
- Pulmonary Hypertension Research and Treatments
- Respiratory Support and Mechanisms
- Congenital Diaphragmatic Hernia Studies
- Infectious Diseases and Tuberculosis
- IgG4-Related and Inflammatory Diseases
- Simulation-Based Education in Healthcare
- Advanced X-ray and CT Imaging
- Organ and Tissue Transplantation Research
- Ocular Diseases and Behçet’s Syndrome
- Transplantation: Methods and Outcomes
- Trace Elements in Health
- Tuberculosis Research and Epidemiology
- Head and Neck Surgical Oncology
- Polyomavirus and related diseases
- Autoimmune and Inflammatory Disorders
- Heart Rate Variability and Autonomic Control
- Blood disorders and treatments
- Diagnosis and treatment of tuberculosis
East Carolina University
2006-2011
Cleveland Clinic
1992-2008
Maastricht University Medical Centre
2005
University of Cincinnati
2005
University of Cincinnati Medical Center
2005
Medical University of South Carolina
2005
Johns Hopkins University
1990-1991
The aim of the present study was to investigate efficacy infliximab for treatment extrapulmonary sarcoidosis. A prospective, randomised, double-blind, placebo-controlled trial conducted, with at 3 and 5 mg·kg −1 body weight administered over 24 weeks. Extrapulmonary organ severity determined by a novel tool (extrapulmonary physician tool; ePOST) an adjustment number organs involved (ePOSTadj). In total, 138 patients enrolled in versus placebo chronic corticosteroid-dependent pulmonary...
Rituximab, a monoclonal antibody directed against the B-lymphocyte antigen CD20, has shown promise in several autoimmune disorders. Pulmonary alveolar proteinosis (PAP) is an disorder characterised by autoantibodies to granulocyte-macrophage colony-stimulating factor (GM-CSF). An open-label, proof-of-concept phase II clinical trial was conducted 10 PAP patients. The intervention consisted of two intravenous infusions rituximab (1,000 mg) 15 days apart. Bronchoalveolar lavage (BAL) fluid and...
Computed tomographic (CT) scans of the chest in 39 patients with Pneumocystis carinii pneumonia (PCP) were reviewed to determine spectrum and frequency CT manifestations PCP. Parenchymal disease was categorized as either bilateral or unilateral, symmetric asymmetric, diffuse patchy. Infiltrates classified interstitial, airspace, mixed. On this basis, three patterns involvement identified: a ground-glass patchwork pattern 22 (56%), an interstitial seven (18%). Atypical features PCP included...
Pseudomembranous colitis (PMC) is an infectious usually occurring as a complication of antibiotic use. The computed tomographic (CT) appearances 26 patients with PMC were reviewed. Twenty-three demonstrated abnormal bowel wall, average wall thickness 14.7 mm (range, 3-32 mm); in three patients, was normal. Contrast material trapped between thickened folds corresponded to the broad transverse bands described on plain radiographs. Pancolonic involvement seen 13 cases, while seven had...
To investigate the antioxidant response of respiratory epithelium to chronic airway inflammation in asthma, major intracellular antioxidants [copper and zinc-containing superoxide dismutase (Cu,Zn-SOD) manganese-containing SOD (Mn-SOD), catalase, glutathione peroxidase] were quantitated bronchial epithelial cells healthy control asthmatic individuals. Although catalase peroxidase asthmatics similar activity not on inhaled corticosteroid (-CS) was lower than (+CS) controls. Investigation...
Lung transplantation has been steadily developing as a therapeutic option for end-stage lung disease.Retrospective analysis of all 26 patients who underwent at the Cleveland Clinic Foundation between February 1990 and 1992.Nineteen single-lung transplantations seven bilateral were performed. The 1-year actuarial survival recipients was 65%. A trend noted towards better in with emphysema (100%) poorer those pulmonary hypertension (37.5%). Fungal sepsis reimplantation injury most common causes...
Salmeterol is safe and FDA-approved, but it should be used only as part of a total program that includes education, smoking cessation, oxygen supplementation, rehabilitation.