A5103212725- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Molecular Biology Techniques and Applications
- Cancer Treatment and Pharmacology
- RNA modifications and cancer
- Hernia repair and management
- Cancer Diagnosis and Treatment
- Cancer and Skin Lesions
- Kruppel-like factors research
- Helicobacter pylori-related gastroenterology studies
- Renal Transplantation Outcomes and Treatments
- Organ Donation and Transplantation
- Cancer survivorship and care
- RNA Research and Splicing
- Galectins and Cancer Biology
- Wnt/β-catenin signaling in development and cancer
- Genomics and Chromatin Dynamics
- Thyroid and Parathyroid Surgery
- Appendicitis Diagnosis and Management
- Intraperitoneal and Appendiceal Malignancies
- Breast Implant and Reconstruction
- Organ Transplantation Techniques and Outcomes
- Thyroid Cancer Diagnosis and Treatment
Bahçeşehir University
2024
Hitit Üniversitesi
2018-2021
Istanbul Bilim University
2019
Memorial Ankara Hospital
2019
Ankara University
2018
Istanbul University
2011-2017
Liv Hospital
2017
Acıbadem University
2017
Bursa Uludağ Üni̇versi̇tesi̇
2017
Marmara University
2017
Abstract Background and Aim: With the introduction of H2 receptor antagonists proton pump inhibitors, incidence elective surgery for peptic ulcer (PU) diseases has decreased, although complications PU such as perforation bleeding have remained fairly constant. The purpose this study was to identify risk factors that predict morbidity mortality in patients with perforated PU. Methods: records 269 who were operated on reviewed retrospectively. following analyzed terms mortality: age >65...
1005 Background: The MF07-01 trial is a multicenter phase III randomized of treatment naive stage IV BC patients comparing loco-regional surgery (LRS) followed by appropriate systemic therapy (ST) vs ST alone. Aims: To compare 3-year survival and progression (LRP). Methods: At initial diagnosis were 1:1 to LRS group or group. After consideration retrospective studies, we hypothesized at 36 months difference between the two groups be 18%. Assuming 10% drop out rate with one sided log-rank...
The aim of this prospective study was to investigate the effects early onset rehabilitation program on shoulder mobility, functional status, lymphedema, and incidence postoperative complications in patients who had modified radical mastectomy. Fifty-seven women were randomly assigned either treatment group or home exercise groups, which consisted 27 30 patients, respectively. After removal drains, instructed 15 sessions individual continued with home-based physical activity program. groups...
Quantitative gene expression measurements from tumor tissue are frequently compared with matched normal and/or adjacent for diagnostic marker selection as well assessment of the degree transcriptional deregulation in cancer. Selection an appropriate reference (RG) or RG panel, which varies depending on cancer type, molecular subtypes, and tissues used interindividual calibration, is crucial accurate quantification expression. Several panels have been suggested breast making comparisons among...
Abstract Introduction: Previous reports of carefully selected patients presenting with stage IV breast cancer (BC) suggest that surgery on the primary tumor may result in improved survival, but this remains unproven. The MF07-01 trial is a phase III randomized controlled BC women distant metastases at presentation who receive loco-regional (LR) treatment for intact compared those do not such treatment. Aim: objective to compare overall survival (OS) treated or without initial LR resection...
CpG hypermethylation in gene promoters is a frequent mechanism of tumor suppressor silencing various types cancers. It usually occurs at early steps cancer progression and can be detected easily, giving rise to development promising biomarkers for both detection cancer, including breast cancer. 5-aza-2'-deoxycytidine (AZA) DNA demethylating anti-cancer agent resulting induction genes suppressed via hypermethylation.Using microarray expression profiling AZA- or DMSO-treated non-tumorigenic...
Overexpression and alterations in the glycosylation of gastric mucins have been described colorectal carcinoma. The purpose our study was to confirm aberrant expression MUC5AC carcinoma, investigate relationships between clinicopathological parameters expression, determine if may be a prognostic factor for Immunohistochemical staining using an antibody against tandem repeat epitopes performed on tumor specimens (n = 41), their metastatic tumors regional lymph nodes 21) normal colonic mucosa...
Improving the diagnosis of acute appendicitis in order to prevent unnecessary surgery is crucial. This study was intended identify role serum inflammatory markers patients with preliminary a retrospective design. Eighty-five were recruited this within period November-December 2003. The average age 31.8 years (ranged from 15 85). There 62 males (72.9%) and 23 females (27.1%). In addition performing routine tests, preoperative samples obtained measure C-reactive protein, interleukin-6,...
The management of duodenal traumas remains controversial. experience Ankara Numune Training and Research Hospital Emergency Surgery Department with injuries during a 10-year period was analyzed to identify trends in operative sources duodenum-related morbidity mortality.Between 1994 2003, 1799 patients blunt abdominal trauma were operated on the incidence 2.8% (50 patients). penetrating 31 (62%) 19 (38%). Primary repair (PR) injury performed 24 (48%) patients, primary tube duodenostomy...
Abstract Background Breast carcinoma is a frequent disease that affects the female population. As for other malignant diseases, several studies have been carried out in an attempt to identify its etiology, yet etiological agent has not clearly defined. The relationship between thyroid and breast cancer still being investigated. However, most of this field are conflicting discussions on continue. Patients Method Our prospective open study was conducted 136 consecutive patients operated...
Background Breast cancer is a remarkably heterogeneous disease. Luminal, basal-like, "normal-like", and ERBB2+ subgroups were identified shown to have different prognoses. The mechanisms underlying this heterogeneity are poorly understood. In our study, we explored the role of cellular differentiation senescence as potential cause heterogeneity. Methodology/Principal Findings A panel breast cell lines, isogenic clones, tumors used. Based on their ability generate senescent progeny under...
Objective: Phyllodes tumor (PT) is a rare biphasic breast neoplasm that accounts for less than 1% of all tumors.The aim this study was to evaluate the clinicopathologic features, diagnostic difficulties, and therapeutic outcomes patients with PT. Materials Methods:A total 48 female who underwent surgery PT were included in study.Patient characteristics, features tumors, findings, surgical outcomes, adjuvant therapies, follow-up findings retrospectively evaluated. Results:The mean age 35...
Objective: Sentinel lymph node (SLN) scintigraphy is used widespread in breast cancer, but the effect of radionuclide agent, injection technique, method biopsy, tumor localization, size remain controversial.We examined effects excisional biopsy rate SLN identification with lymphoscintigraphy (LS) and intraoperative gamma probe (IGP).Material Methods: One hundred patients (age range: 28-79 yr) cancer were included study.They consisted two groups: Group 1; there 58 without biopsy.Group 2; 42...