A5048005597- Computational Drug Discovery Methods
- Cannabis and Cannabinoid Research
- SARS-CoV-2 and COVID-19 Research
- Multicomponent Synthesis of Heterocycles
- Viral gastroenteritis research and epidemiology
- COVID-19 Clinical Research Studies
- Neurotransmitter Receptor Influence on Behavior
- Engineering and Information Technology
- Technology-Enhanced Education Studies
- Machine Learning in Bioinformatics
- Early Childhood Education and Development
- Emotional Intelligence and Performance
- Network Security and Intrusion Detection
- Topic Modeling
- Pharmacological Receptor Mechanisms and Effects
- Education and Critical Thinking Development
- Protein Structure and Dynamics
- Synthesis and biological activity
- Cervical Cancer and HPV Research
- Gait Recognition and Analysis
- Cancer Research and Treatments
- Dental Trauma and Treatments
- Synthesis and Reactivity of Heterocycles
- Antimicrobial Peptides and Activities
- Pediatric health and respiratory diseases
Mayo Clinic in Arizona
2024
Maharaja Sayajirao University of Baroda
2014-2023
Government Medical College
2023
SRM University
2023
ABES Engineering College
2022
University College of Medical Sciences
2022
ETH Zurich
2022
Delhi Technological University
2016-2021
Sarasota Memorial Hospital
2021
Technical University of Denmark
2017
A novel series of hybrid molecules were designed and synthesized by fusing the pharmacophoric features cholinesterase inhibitor donepezil diarylthiazole as potential multitarget-directed ligands for treatment Alzheimer’s disease (AD). The compounds showed significant in vitro anticholinesterase (anti-ChE) activity, most potent compound (44) among them showing highest activity (IC50 value 0.30 ± 0.01 μM) AChE (1.84 0.03 BuChE. Compound 44 mixed inhibition enzyme kinetic studies. Some...
Over the past few decades, renewable energy has garnered enormous attention which increased importance of photovoltaic systems significantly. However, these PV are susceptible to a variety faults resulting in variability output power. In absence timely detection, cause power decrease, rendering array system unreliable. Additionally, some cases, falls prey aging or wear and tear. Therefore, detection fault also identification type is paramount ensure optimal functioning system. this paper,...
Objective: The purpose of this study was to investigate the efficacy a digital game-based course build domain knowledge and social emotional competencies empathy compassion in adolescents. Materials Methods: used game Bury me, my Love with an accompanying which administered 201 participants between ages 13-18 across United Arab Emirates (UAE) India. Standardized self-reports were score on measures attitudes, empathy, before after intervention. Mixed analyses variance conducted 1...
Developing peripherally active cannabinoid 1 (CB1) receptor antagonists is a novel therapeutic approach for the management of obesity. An unusual phenothiazine scaffold containing CB1R antagonizing hit was identified by adopting virtual screening work flow. The so further modified introducing polar functional groups into it to enhance surface area and decrease hydrophobicity resulting molecules. CB1 antagonistic activity designed compounds computed previously established pharmacophore three...
Type 2 diabetes mellitus is described by insulin resistance and high fasting blood glucose. Increased levels of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme result in metabolic syndrome. Inhibition 11β-HSD1 decreases glucose production increases hepatic sensitivity. Use selective inhibitors could prove to be an effective strategy for the treatment disease. It was decided identify essential structural features required any compound possess inhibitory activity. A dataset 139...
A four featured pharmacophore and predictive 3D-QSAR models were developed which used for virtual screening of the Asinex database to get chemically diverse hits peripherally active CB1 receptor antagonists.
The success of social and emotional learning (SEL) in the classroom hinges on buy-in teachers, as they serve principal implementers SEL initiatives. This is particularly relevant contexts where nascent emerging. In response to this need, we developed a scale measure teachers' beliefs about factors that promote (CSEL). We validated India, has recently gained attention, large sample teachers (N = 2097). Factor analysis revealed three-factor structure comprising healthy management, inclusive...
Heterocycles of this series resemble MDM2 inhibitors.
This paper is a qualitative evaluation of student netbooks used in classroom setting. Netbooks are thought to be one promising development the next generation learning devices, pairing everyday PC capabilities with purposeful design built for students and schools. The findings suggest that appropriate engaging unique needs individual primary school students. Nevertheless, specifications do not yet address some classroom-level practices crucial success technology classrooms. describes key...
A novel technique is proposed for categorizing sports events in videos by tracking the positional and angular displacements of centroid moving object between successive frames. The various sporting contained are distinguished either speed motion, instance walking, jogging running, or trajectory made human body while diving, kicking, bending, lifting weights, jumping playing golf. motion measured randomness position vector magnitude, time-series represents trajectory. Our method employs...
This paper presents a comparison of sentiment analyses performed on dataset French tweets and it's machine translated version (in English) using Google Translate. In recent years, fairly new Python library called spaCy has gained significant traction in performing languages other than English due to its multilingual support. There still haven't been major publications evaluating usage for the said purpose. this research, TFIDF features are extracted from three different N-grams (Unigrams,...
In this paper we discuss the use of short, specific videos to communicate ethnographic data throughout product development process. Ethnographic nature provide complex information in short “utterances” (zero three minutes) that researchers effectively convey local meaning other participants Video utterances can be used create opportunities for participation ideation, recognize key features and identify problems during testing. With proper scaffolding, video are an effective means contextual...
Accumulating evidence of the impact social and emotional learning (SEL) on student well-being as well academic performance has led to an increased interest in understanding measuring SEL students. However, most existing measures have been developed English there is a paucity culturally relevant other languages. In this study, we present short, sensitive 8-item scale Hindi entitled Social Emotional Learning Orientation Scale (SELOS). Factor structure SELOS was established through exploratory...
<h3>Background</h3> Protein citrullination, i.e. conversion of arginine residues into citrulline residues, is a post-translational modification catalyzed by PAD, and an important pathophysiological determinant in conditions such as Rheumatoid arthritis (RA). Identification citrullination sites on putative autoantigens likely to enhance our understanding PAD9s substrate specificity. <h3>Objectives</h3> Citrullinated fibrinogen autoantigen linked the pathophysiology RA.We have applied novel...
Digital pedagogy is the intentional integration of technology into teaching and learning to build rich experiences. Given this potential pace digitization education, it important define, assess develop teachers’ digital pedagogical competence. Although there are several self-report measures that competence, these do not include scenario-based tools. Scenario-based assessments allow evaluation knowledge skills in real-world applications. We present here Pedagogy Competence Scale (DiPeCoS), a...