A5090480978- Pancreatitis Pathology and Treatment
- Pancreatic and Hepatic Oncology Research
- Liver Disease Diagnosis and Treatment
- Gastrointestinal Bleeding Diagnosis and Treatment
- Eosinophilic Esophagitis
- Peptidase Inhibition and Analysis
- Lipid metabolism and disorders
- Fibroblast Growth Factor Research
- Connective Tissue Growth Factor Research
- Cancer-related gene regulation
- Pediatric Hepatobiliary Diseases and Treatments
- HER2/EGFR in Cancer Research
- Phagocytosis and Immune Regulation
- Tryptophan and brain disorders
- Wnt/β-catenin signaling in development and cancer
- COVID-19 diagnosis using AI
- Hepatocellular Carcinoma Treatment and Prognosis
- Bone Metabolism and Diseases
- PI3K/AKT/mTOR signaling in cancer
- Garlic and Onion Studies
- Bone and Joint Diseases
- Diabetes and associated disorders
- Pneumocystis jirovecii pneumonia detection and treatment
- Gastrointestinal Tumor Research and Treatment
- IL-33, ST2, and ILC Pathways
Shandong Provincial QianFoShan Hospital
2006-2024
Shandong First Medical University
2019-2024
Shandong University
2006-2019
University Gastroenterology
2016
Qilu Hospital of Shandong University
2006-2007
Epigallocatechin gallate (EGCG), a major component of green tea extracts, is known to have anti-fibrotic properties in many organs. The aim present study was investigate effects EGCG on rat pancreatic fibrosis induced by diethyldithiocarbamate (DDC). Oral gavages different dose (50, 100 and 200 mg/kg daily for 8 weeks) ameliorated histological changes significantly suppressed collagen deposition dose-dependent manner. Meanwhile, administration inhibited overexpression TGF-β1 α-smooth muscle...
Background/Aims: High-fat diets contribute to pancreatic fibrogenesis, but the pathogenesis remains unclear.This study investigated role of nuclear factor kappa B (NF-κB) in high-fat diet-induced fi brosis rats.Methods: Male Wistar rats were fed a diet or standard normal chow for 20 weeks.Pancreatic fibrosis was determined by Sirius red staining.Immunohistochemical staining, reverse transcription-polymerase chain reaction and Western blotting used identify NF-κB-associated genes protein...
The present study compared the clinical effectiveness of electroacupuncture (EA), monotherapy and combination therapy involving administration EA mosapride in diabetic patients with severe or mild symptoms suggestive gastroparesis. A total 56 type 2 diabetes who had gastroparesis for >3 months were divided into two groups according to Gastroparesis Cardinal Symptom Index (GCSI) score, including 33 group (GCSI score <3.5) 23 ≥3.5). Initially, all received 14 days. An effective response was...
It has been reported that serum soluble E-selectin (sE-selectin) may be increased in some inflammatory liver diseases. The purpose of our study was to investigate changes sE-selectin, T lymphocyte subsets, natural killer (NK) cells, and HBV load patients with chronic hepatitis B (CHB), analyze the relationship between them, discuss their significances.Fifty-four fourteen controls were studied. Serum NK virus (HBV) detected by enzyme-linked immunosorbent assay (ELISA), flow cytometry (FCM),...
Pathogenesis and effective therapeutics of chronic pancreatic inflammation fibrosis remain uncertain.To investigate the effects sulfasalazine (SF) on fibrogenesis.Chronic injury in rats was induced by diethyldithiocarbamate (DDC) interfered SF through intraperitoneal injection. The were divided into five groups: group N, normal control group, treated with dilated water only; DS1, received (10 mg/kg) 2 hours before DDC treatment; DS2, then (100 mg/kg, twice a week); DS3, DDC, thrice only....
Hepatocellular carcinoma (HCC) typically originates from HBV or HCV associated liver cirrhosis. Primary Sjögren’s syndrome (pSS) is a kind of autoimmune disease. A sixty-two year old female patient with mild damage was diagnosed pSS after excluding viral, alcoholic and drug-induced hepatitis according to serum immunological detection biopsy. But when she hospitalized for second time two years later, CT scan revealed neoplasm. Surgery confirmed HCC cirrhosis by pathology. The elevated level...
BACKGROUND Plasma cell myeloma (PCM) is characterized by hypercalcemia, renal impairment, anemia, and bone destruction. While pleural effusion, ascites, abdominal pain, bloody stool are common manifestations of lung disease or gastrointestinal disorders, they rarely observed in patients with PCM. CASE SUMMARY A 66-year-old woman presented complaints recurrent chest tightness, wheezing, bloating accompanied stools. Computed tomography revealed effusion ascites. Pleural tests showed...
The aim of this study was to observe the effect AG1478, an inhibitor epidermal growth factor receptor, on cell proliferation, cycle and apoptosis human hepatoma HepG2 cells. Cell counting kit-8 assay employed examine survival rates cultured cells after treatments with different concentrations AG1478 for 24 h. Flow cytometry performed determine apoptosis. Immunohistochemistry used measure expression c-Myc protein. 5, 10, 20 40 μmol/L h were 76.0%, 59.6%, 51.2% 42.1%, respectively. apoptotic...
Objective: The main purpose was to investigate expression of CDH11 in pancreatic tissues and analyze its relations with clinical characteristics patients cancer (PC).Methods: Expression cancerous adjacent were detected by immunohistochemistry staining, their associations analyzed.The text mining methods used assist the study effect on prognosis.Results: A total 79 PC enrolled study, including 51 (64.6%) men 28 (35.4%)women a median age 62 (41 -84).The higher than that both positively...
Objective To investigate the effects of high-fat diet on pancreatic acinar cells' IP3 expression and CCK-induced amylase release in rats.Methods Male Wistar rats were divided into group normal group,they fed for 4 weeks.Blood triglycerides,cholesterol,amylase glucose levels determined by automatic biochemical analyzer.Pancreatic tissues taken histopathological observations.Pancreatic cells isolated cultured,and intracellular inositol 1,4,5-trisphosphate (IP3) was detected using a commercial...
The incidence of acute pancreatitis (AP) is high. Severe (SAP) has attracted attention from worldwide experts and scholars because its severe symptoms, systemic complications, poor prognosis. Endocrine damage occurs in patients, but the underlying pathogenesis remains unclear. This article reviews progress research endocrine function impairment pancreatitis. Key words: Acute pancreatitis; Pancreatic function; Pancreatic exocrine
There are many pathological types of pancreatic space-occupying lesions with different clinical manifestations, among which ductal adenocarcinoma can be found usually and is high malignant.In addition to cancer, some rare tumors appear a benign process, the patients′ prognosis totally different.But it tough distinguish from cancer.The combination laboratory examination imaging has great significance for timely accurate diagnosis, treatment evaluation.Herein we present review regard...
Pancreatic cancer is a highly malignant digestive tumor, about 90% of which originate from ductal adenocarcinoma glandular epithelium.Its morbidity and mortality have increased significantly in recent years, the 5-year survival rate<6%, making it one tumors with worst prognosis.The early diagnosis rate disease low operative high.The ratio male to female about(1.5~2)∶1, therapeutic regimen changes single operation multidisciplinary treatment.In there not been many new breakthroughs treatment...