Abstract Background Heart failure (HF) continues to be the major cause of hospitalizations. Despite numerous significant therapeutic progress, mortality rate HF is still high. This longitudianl cohort study aimed investigate associations between hematologic inflammatory indices neutrophil percentage-to-albumin ratio (NPAR), neutrophil-to-lymphocyte (NLR), platelet-to-lymphocyte (PLR), and all-cause in community-dwelling adults with HF. Methods Adults aged 20 older US National Health...

Tuberous sclerosis complex (TSC) is caused by mutations in TSC1 and TSC2, leading to mammalian target of rapamycin hyperactivation. Patients with TSC develop hamartomas brain, lungs, liver skin. Two epidemiological studies, performed Minnesota, U.S.A., have estimated the incidence be 0·28-0·56 per 100 000 person-years (PY), based on < 12 patients. Furthermore, whether common comorbidities are associated this rare disease not known.To estimate investigate associations other comorbidities,...

Acral melanoma (AM) is the most common histopathological subtype of malignant in Asians. However, differences mutational profiles underlying AM and nonacral cutaneous (NAM) Asians are not well understood.To augment understanding prevalence, patterns associations various mutations between different subtypes melanoma.We performed comprehensive genomic profiling 409 cancer-associated genes, using next-generation sequencing, 66 primary melanomas comprised 45 AMs 21 NAMs.Most (n = 27/45; 60%),...

Hyperglycaemia causes endothelial dysfunction, which is the initial process in development of diabetic vascular complications. Upon injury, cells undergo an endothelial-to-mesenchymal transition (EndMT), lose their specific marker, and gain mesenchymal phenotypes. This study investigated effect liraglutide, a glucagon-like peptide 1 (GLP-1) receptor agonist, on EndMT inhibition neointima formation mice induced by streptozotocin. The with wire-induced injury right carotid artery were treated...

To evaluate procedure outcomes, complications, and the predictors of device success while using Tornus in CTO revascularization.The percutaneous coronary intervention (PCI) for chronic total occlusion (CTO) may be limited by presence severe calcified lesions, especially smallest balloon uncrossable arteries. A penetrating (Tornus) could improve rate.Device angiographic rates as well procedural complications were assessed 56 patients, who consecutively retrospectively enrolled into this...

Diabetic cardiomyopathy (DCM) is characterized by cardiac fibrosis and stiffness, which often develops into heart failure. This study investigated the role of Ras protein-specific guanine nucleotide releasing factor 1 (RasGRF1) in development DCM. Forty-eight mice were divided four groups (n = 12 per group): Group 1: Wild-type (WT) mice, 2: RasGRF1 deficiency (RasGRF1-/-) mice. 3: Streptozotocin (STZ)-induced diabetic WT 4: STZ-induced RasGRF1-/- Myocardial functions assessed echography....

Abstract Purpose. To determine the incidence of testicular microlithiasis (TM) in Taiwanese males who were referred for scrotal sonography (US) and to evaluate association between TM cancer, with state‐of‐the‐art equipment. Methods. This retrospective study included 513 underwent US a period 7 months. The images charts each patient reviewed presence note relevant clinical information. Results. data all patients analyzed. Their age was 0–91 years (mean, 54.3 years). overall 14.4% (74/513);...

Although established guidelines currently recommend the use of CHA2DS2-VASc score for evaluating embolic risk in AF patients, few studies have evaluated predicting cardiovascular outcomes patients with acute myocardial infarction (AMI). The aim this study was to determine whether is a predictor major adverse cardiocerebral vascular event (MACCE) AMI patients. This analyzed data Taiwan National Health Insurance Research Database from January 2008 December 2012. Cardiovascular were according...

Abstract Atrial fibrillation (AF) is an important complication of acute myocardial infarction (AMI). The association between AF and serum lipid profile unclear statin use for lowering the incidence new-onset remains controversial. objective this study was to investigate whether statins confer a beneficial effect on after AMI. Data available in Taiwan National Health Insurance Research Database 32886 AMI patients 2008 2011 were retrospectively analyzed. Total 27553 (83.8%) had complete 1-yr...

The prognostic value of easily accessible hematologic biomarkers, such as the neutrophil-to-HDL ratio, well monocyte-to-HDL, lymphocyte-to-HDL, and platelet-to-HDL ratios, remains underexplored in patients with established ischemic heart disease (IHD). Community-dwelling adults aged ≥ 20 IHD from National Health Nutrition Examination Survey (NHANES) 1999–2018 were eligible. Mortality was tracked through linkage to Death Index (NDI) until end 2019. Cox regressions examined associations...

Few studies have investigated the clinical efficacy and pulmonary side effects of different P2Y12 inhibitors in acute coronary syndrome (ACS) patients. The aim this study was to explore impact forced expiratory volume 1 second over vital capacity (FEV1/FVC) ratio on outcomes ACS patients treated with dual antiplatelet therapy after percutaneous intervention (PCI).ACS who underwent PCI, had documented pre-existing spirometry tests, received aspirin either ticagrelor or clopidogrel were...

Controlling modifiable risk factors (MRFs) in patients with cardiovascular diseases has been shown to be effective reducing re-hospitalization rates. The aim of this study was investigate the rates controlled MRFs and clinical outcomes after pharmacist interventions myocardial infarction (MI) hospital discharge.This prospective randomized conducted at one medical center Taiwan, enrolled MI from January 1, 2012 December 31, 2014. Patients received medication reconciliation education a before...

Use of statistical models for assessing the clinical risk readmission to medical and surgical intensive care units is well established. However, predicting coronary unit (CCU) are rarely reported. Therefore, this study investigated characteristics outcomes patients readmitted CCU identify factors establish a scoring system identifying at high readmission.Medical data were collected 27,841 with history single multi-center healthcare provider in Taiwan during 2001-2019. Characteristics...

Introduction: Cardiovascular disease is one of the leading causes mortality worldwide. Acute myocardial infarction (AMI) associated with weather change. The study aimed to investigate if change was among risk factors coronary artery influence AMI occurrence in Taiwan and generate a model predict probabilities specific clinical conditions. Method: This observational utilized National Health Insurance Research Database daily reports from Central Weather Bureau evaluate discharge records...

The outcomes of patients with concomitant left main coronary artery (LMCA) and right (RCA) diseases are reportedly worse than those only LMCA disease. To date, few studies have investigated the clinical impact percutaneous intervention (PCI) on RCA stenosis during same hospitalization, in which disease was treated. This study aimed at comparing between without hospital course for intervention.From a total 776 who were undergoing PCI to treat disease, 235 significant (more 70% stenosis)...

Background . This study evaluated the impact on clinical outcomes using a cloud computing system to reduce percutaneous coronary intervention hospital door-to-balloon (DTB) time for ST segment elevation myocardial infarction (STEMI). Methods A total of 369 patients before and after implementation transfer protocol were enrolled. Of these patients, 262 transferred through while other 107 traditional referral process. Results There no significant differences in DTB time, pain door STEMI...

We investigated the accuracy of various bleeding risk scores to estimate in patients with acute myocardial infarction (AMI) managed percutaneous coronary intervention (PCI) access via radial artery.We retrospectively enrolled 1,651 who were definitively diagnosed ST-elevation (STEMI) or non-STEMI (NSTEMI). assessed predictive validities 30-day events scoring systems using receiver operating characteristic curves.Overall, ACUITY-HORIZONS exhibited highest area under curve predict bleeding,...

In patients with end-stage renal disease (ESRD), acute myocardial infarction (AMI) increases the risks of cardiovascular events, death, and bleeding. Several scores have been developed for predicting ischemic bleeding outcomes in AMI patients, but none validated specifically ESRD patients.To compare validate different risk as predictors ESRD.This retrospective study enrolled 340 who had received percutaneous coronary intervention while undergoing maintenance hemodialysis ESRD. Ischemic...

Abstract Background: Use of statistical models for assessing the clinical risk readmission to medical and surgical intensive care units is well established. However, predicting coronary unit (CCU) are rarely reported. Therefore, this study investigated characteristics outcomes patients readmitted CCU identify factors establish a scoring system identifying at high readmission. Methods: Medical data were collected 40,187 with history single multi‐center healthcare provider in Taiwan during...