Elderly people are more susceptible to sepsis and experience comorbidities complications than young adults. Serum lactate is a useful biomarker predict mortality in patients with sepsis. Lactate production affected by the severity of sepsis, organ dysfunction, adrenergic stimulation. Whether predictive ability serum will be different between non-elderly elderly unknown. A retrospective cohort study was conducted compare prognostic value hyperlactatemia predicting (≥65 years) (<65 This...

Background. The study aimed to verify the effect of primary percutaneous coronary intervention (PPCI) with &lt;60 min door-to-balloon time on ST segment elevation myocardial infarction (STEMI) patients’ prognoses. Methods. Outcomes patients receiving PPCI were compared those 60–90 min. Result. Totally, 241 STEMI (191 Killip classes I or II) and 104 (71 received min, respectively. II had better thrombolysis in (TIMI) flow (9.2% fewer TIMI &lt;3, <mml:math...

To build machine learning models for predicting the risk of in-hospital death in patients with sepsis within 48 h, using only dynamic changes patient's vital signs.This retrospective observational cohort study enrolled septic from five emergency departments (ED) Taiwan. We adopted seven variables, i.e., age, sex, systolic blood pressure, diastolic heart rate, respiratory and body temperature.Among all 353,253 visits, after excluding 159,607 visits (45%), group consisted 193,646 ED visits....

Background . Several comorbidities contribute to an increased risk of infections in Parkinson’s disease (PD) as the progresses. However, few studies have examined correlation between sepsis and PD. Aim The aim this study is disclose presentation outcome serious infection patients with PD emergency department. Methods This retrospective cohort enrolled who had were admitted department January 2007 December 2013. For clinical comparison, we compared features, laboratory data, outcomes those...

The aim of this study was to compare quick Sepsis-related Organ Failure Assessment (qSOFA) and Systemic Inflammatory Response Syndrome (SIRS) scores for predicting mortality.A single-center, retrospective adult patients with suspected infection conducted. Area under the curve (AUC) multivariate analyses were used explore associations between qSOFA SIRS mortality.Of 69 115 enrolled, 1798 died within 72 h 5640 28 days. better than at 72-h mortality (AUC: 0.77 vs. 0.64). However, discriminatory...

Elevated serum lactate is associated with higher mortality in sepsis, whereas liver dysfunction levels. We assessed the predictive ability of patients cirrhosis and sepsis.This retrospective study included 12 281 cases suspected infection initial blood drawn during January 2007-December 2013.Using one-to-two propensity score matching analysis, 1053 2106 septic without underlying cirrhosis, respectively, were successfully matched. Lactate levels survivors nonsurvivors 2.58 5.93 mmol/L, (WLC),...

Increased soluble triggering receptor expressed on myeloid cells 1 (sTREM-1) levels have been reported in patients with sepsis. We tested the hypotheses that serum sTREM-1 increase early phase of sepsis and decrease after under appropriate treatment can predict therapeutic outcomes. One hundred fifty-five prospectively underwent blood samples including biochemical data, sTREM-1, biomarkers endothelial dysfunction as well clinical severity index examinations. Blood from Days 1, 4, 7 admission...

Hypoglycemia is associated with a higher risk of death. This study analyzed various body mass index (BMI) categories and mortalities severe hypoglycemic patients type 2 diabetes mellitus (DM) in hospital emergency department.The included 566 adults who were admitted to 1 medical center Taiwan between 2008 2009 diagnosis hypoglycemia. Mortality data, demographics, clinical characteristics the Charlson's Comorbidity Index obtained from electronic records. Patients stratified into 4 groups as...

Concomitant use of some drugs can lead to interactions between them resulting in severe adverse effects. To date, there are few reports incidences Stevens-Johnson syndrome (SJS) associated with combination drug administration. Therefore, we studied the relationship combinations and SJS-related mortality, hope that a retrospective study this nature would provide information crucial for prevention future drug-drug interaction related deaths attributable SJS. This longitudinal used mortality...

This study determined if the use of metformin affected prognostic value hyperlactatemia in predicting 28-day mortality among patients with sepsis and bacteremia. We enrolled adult diabetic Of 590 patients, 162 users nonusers, respectively, were selected propensity matching. The mean serum lactate levels higher than those nonusers (4.7 vs. 3.9 mmol/L, p = 0.044). divided into four groups based on quick Sepsis-related Organ Failure Assessment (qSOFA) scores. No significant difference was found...

Objective: Few studies have focused on factors influencing outcomes of patients with in-hospital cardiac arrest (IHCA) in general wards. The goal this study was to report the adult IHCA wards and identified prognostic factors. Methods: Adult having received cardiopulmonary resuscitation from January 2008 December 2011 were retrospectively reviewed our registry system. primary outcome survival hospital discharge, while secondary sustained return spontaneous circulation (ROSC). Results: A...

Coronary risk scores (CRS) including History, Electrocardiogram, Age, Risk Factors, Troponin (HEART) score and Emergency Department Assessment of Chest pain Score (EDACS) can help identify patients at low major adverse cardiac events. In the emergency department (ED), there are wide variations in hospital admission rates among with chest pain.This study aimed to evaluate impact CRS on disposition symptoms suggestive acute coronary syndrome ED.This retrospective cohort included 3660 adult who...

Background. Several risk scores have been developed to predict and analyze in-hospital mortality short- long-term outcomes of ST-elevation myocardial infarction (STEMI) patients after primary percutaneous coronary intervention (PPCI); these can classify as having a high or low death complications. Objective. To compare the prognostic precision four for predicting in with STEMI treated PPCI. Methods. We performed retrospective cohort analysis who underwent PPCI between 2012 2019 (N = 1346)....

Objective This study assessed the effect of prior statin use on 28-day mortality patients with type 2 diabetes mellitus (DM) who develop bloodstream infections. Methods retrospective cohort included all adult DM bacteremia and verified medication history visited emergency department a single tertiary hospital between January 2007 December 2013. All major adverse consequences including septic shock events, mechanical ventilation, intensive care unit admission, were assessed. Results A total...

Extended-spectrum β-lactamase (ESBL)-positive bloodstream infection (BSI) is on the rise worldwide. The purpose of this study to evaluate impact inappropriate initial antibiotic therapy (IIAT) in-hospital mortality patients in emergency department (ED) with Escherichia coli and Klebsiella pneumoniae BSIs. This retrospective single-center cohort included all adult E. K. BSIs between January 2007 December 2013, who had undergone a blood culture test initiation antibiotics within 6 h ED...

The outbreak of the new coronavirus disease 2019 (COVID-19) has notably affected medical system worldwide and influenced health-seeking behavior people while depleting resources, causing a delay in ST-elevation myocardial infarction (STEMI) management. In this single-center, retrospective cohort study, we compared clinical pictures nontransfer patients who presented to emergency department directly received primary percutaneous cardiovascular intervention (PPCI) from February 1 April 30,...

Background . This study evaluated the impact on clinical outcomes using a cloud computing system to reduce percutaneous coronary intervention hospital door-to-balloon (DTB) time for ST segment elevation myocardial infarction (STEMI). Methods A total of 369 patients before and after implementation transfer protocol were enrolled. Of these patients, 262 transferred through while other 107 traditional referral process. Results There no significant differences in DTB time, pain door STEMI...

Objective . By analyzing closed criminal malpractice claims involving resident physicians, we aimed to clarify the characteristics of litigations and examine litigious errors leading guilty verdicts. Design A retrospective descriptive study. Setting/Study Participants The verdicts pertaining physicians recorded on national database Taiwan justice system were reviewed. Main Outcome Measures documented. Negligence further analyzed identify errors. Results Between January 1, 2000, December 31,...

Abstract Background Elevated serum lactate is associated with higher mortality in sepsis, whereas liver dysfunction levels. We assessed the predictive ability of patients cirrhosis and sepsis. Methods This retrospective study included 12,281 cases suspected infection initial blood drawn during January 2007-December 2013. Results Using one-to-two propensity score matching analysis, 1,053 2,106 septic without underlying cirrhosis, respectively, were successfully matched. Lactate levels...

摘要： 蛋白质提取方法和电泳条件是蛋白质组学研究中双向电泳的关键。本文初步建立起一套适合圆果种黄麻功能叶总蛋白双向电泳(2-DE)分析的高效提取方法及电泳条件，在双向电泳技术中，比较了TCA丙酮、Tris-base/丙酮、Tris-HCl的蛋白提取方法，并优化了上样量和样品制备方法。结果表明, TCA丙酮法提取蛋白质产量高，达79.0 mg g–1，比Tris-base/丙酮法和Tris-HCl的产量分别高出44.2%和114.1%。该法得到的2-DE图谱背景清晰，蛋白点数最多，约602个，较其他两种方法更适合用于黄麻功能叶总蛋白双向电泳分析；350 mg为最佳上样量。这为黄麻蛋白质组学后续研究奠定了基础。

Acute myocardial infarction is a leading cause of cardiogenic shock and mortality. The aim current study to identify factors develop machine learning models that predicts in-hospital mortality ST-segment elevation (STEMI) patients in South-East Asian population. This single center, retrospective study, from presenedt the emergency room at Kaohsiung Chang Gung Memorial Hospital, Taiwan. included non-trauma adults (≥20 years age) who were diagnosed with acute STEMI. A total 1567 met inclusion...