A5088153653- RNA and protein synthesis mechanisms
- RNA Research and Splicing
- Protein Structure and Dynamics
- RNA modifications and cancer
- Bioinformatics and Genomic Networks
- Enzyme Structure and Function
- Genetic Neurodegenerative Diseases
- Genomics and Phylogenetic Studies
- Metabolomics and Mass Spectrometry Studies
National University of Quilmes
2020-2023
Centro Científico Tecnológico - San Juan
2023
Consejo Nacional de Investigaciones Científicas y Técnicas
2021
Abstract DisProt (URL: https://disprot.org) is the gold standard database for intrinsically disordered proteins and regions, providing valuable information about their functions. The latest version of brings significant advancements, including a broader representation functions an enhanced curation process. These improvements aim to increase both quality annotations coverage at sequence level. Higher has been achieved by adopting additional evidence codes. Quality improved systematically...
The RepeatsDB database (URL: https://repeatsdb.org/) provides annotations and classification for protein tandem repeat structures from the Protein Data Bank (PDB). repeats are ubiquitous in all branches of tree life. accumulation solved new possibilities detection, but also increasing need annotation. Here we present 3.0, which addresses these challenges presents an extended scheme. major conceptual change compared to previous version is hierarchical combining top levels based solely on...
Conformational changes in RNA native ensembles are central to fulfill many of their biological roles. Systematic knowledge the extent and possible modulators this conformational diversity is desirable better understand relationship between dynamics function. We have developed CoDNaS-RNA as first database molecules. Known structures retrieved clustered identify alternative conformers each molecule. Pairwise structural comparisons all within cluster allows measure variability Additional...
Protein regions consisting of arrays tandem repeats are known to bind other molecular partners, including nucleic acid molecules. Although the interactions between repeat proteins and DNA already widely explored, studies characterising RNA-binding lacking. We performed a large-scale analysis human devoted expanding knowledge about experimentally reported as This work is timely because release full set accurate structural models for proteome amenable detection using methods. The main goal our...
Abstract Conformational changes in RNA native ensembles are central to fulfill many of their biological roles. Systematic knowledge the extent and possible modulators this conformational diversity is desirable better understand relationship between dynamics function. We have developed CoDNaS-RNA as first database molecules. Known structures retrieved clustered identify alternative conformers each molecule. Pairwise structural comparisons within cluster allows measure variability Additional...