A5045027915- Antimicrobial Peptides and Activities
- Lipid Membrane Structure and Behavior
- Bacteriophages and microbial interactions
- Protein Structure and Dynamics
- Probiotics and Fermented Foods
- Enzyme Structure and Function
- Biochemical and Structural Characterization
- Immune Response and Inflammation
- Environmental and Ecological Studies
- Computational Drug Discovery Methods
- Sustainability and Climate Change Governance
- Agriculture and Rural Development Research
- Advancements in Transdermal Drug Delivery
- Chemical Synthesis and Analysis
- Bioinformatics and Genomic Networks
- Escherichia coli research studies
- Economic and Environmental Valuation
- Research on Leishmaniasis Studies
- Agriculture, Land Use, Rural Development
- Global trade, sustainability, and social impact
- Protein Hydrolysis and Bioactive Peptides
- Environmental Conservation and Management
- RNA and protein synthesis mechanisms
- Redox biology and oxidative stress
University of Buenos Aires
2017-2023
National University of Quilmes
2016-2023
Fundación Ciencias Exactas y Naturales
2017-2023
Consejo Nacional de Investigaciones Científicas y Técnicas
2017-2023
Instituto de Física de Buenos Aires
2023
Instituto de Química y Fisicoquímica Biológicas
2023
University of Padua
2023
Institute of Astronomy and Space Physics
2020
Abstract DisProt (URL: https://disprot.org) is the gold standard database for intrinsically disordered proteins and regions, providing valuable information about their functions. The latest version of brings significant advancements, including a broader representation functions an enhanced curation process. These improvements aim to increase both quality annotations coverage at sequence level. Higher has been achieved by adopting additional evidence codes. Quality improved systematically...
In this work; we investigated the differential interaction of amphiphilic antimicrobial peptides with 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) lipid structures by means extensive molecular dynamics simulations. By using a coarse-grained (CG) model within MARTINI force field; simulated peptide-lipid system from three different initial configurations: (a) in water presence pre-equilibrated bilayer; (b) inside hydrophobic core membrane; and (c) random configurations that allow...
Alpha hemolysin of Escherichia coli (HlyA) is a pore-forming protein, which prototype the "Repeat in Toxins" (RTX) family. It was demonstrated that HlyA–cholesterol interaction facilitates insertion toxin into membranes. Putative cholesterol-binding sites, called cholesterol recognition/amino acid consensus (CRAC), and CARC (analogous to CRAC but with opposite orientation) were identified HlyA sequence. In this context, two peptides synthesized, one derived from site domain (residues...
Aurein 1.2 is an antimicrobial peptide from the skin secretion of Australian frog. In previous experimental work, we reported a differential action aurein on two probiotic strains Lactobacillus delbrueckii subsp. bulgaricus (CIDCA 331) and lactis 133). The differences found were attributed to bilayer compositions. Cell cultures CIDCA 331-derived liposomes showed higher susceptibility than ones derived 133 strain, leading content leakage structural disruption. Here, used molecular dynamics...
Aurein 1.2 is an antimicrobial peptide (AMP) with known lytic activity against bacterial membranes. Our previous studies revealed a differential action of aurein by both experimental and computational methods. This was over membranes two related probiotic strains, where the main difference between number glycolipids in lipid composition. In this work, we aimed to investigate interaction model varying glycolipid content. To end, performed extensive molecular dynamics simulations using MARTINI...
Glutaredoxins are small proteins that share a common well-conserved thioredoxin-fold and participate in wide variety of biological processes. Among them, class II Grx redox-inactive involved iron–sulfur (Fe-S) metabolism. In the present work, we report different structural dynamics aspects 1CGrx1 from pathogenic parasite Trypanosoma brucei differentiate it other orthologues by presence parasite-specific unstructured N-terminal extension whose role has not been fully elucidated yet. Previous...
Nas últimas décadas, os bancos de sementes ganharam uma importância crescente no domínio da agricultura e alimentação. No entanto, apesar serem instituições-chave relacionadas à utilização conservação recursos naturais, não foram suficientemente analisadas pelas ciências sociais. Neste trabalho, analisamos através abordagem qualitativa, que combina tanto entrevistas em profundidade com atores referentes dos na Argentina -um país onde a é um setor fundamental para economia- coma análise...
ABSTRACT The Aurein 1.2 is an anuran antimicrobial peptide (AMP) with a proven lytical activity against bacterial membranes. Previously, we found differential action of aurein by both experimental and computational methods. This was over membranes two related probiotic strains, where the main differences between were number glycolipids on lipid composition. In present work, focused behavior at its interaction bacterium model different amounts in their We carried out extensive molecular...