A5082399579- Hypothalamic control of reproductive hormones
- Ovarian function and disorders
- Neurogenesis and neuroplasticity mechanisms
- Hormonal and reproductive studies
- Neuroendocrine regulation and behavior
- COVID-19 Impact on Reproduction
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Healthcare and Venom Research
- Stress Responses and Cortisol
- Reproductive Biology and Fertility
- Fetal and Pediatric Neurological Disorders
- Growth Hormone and Insulin-like Growth Factors
- Genetics and Neurodevelopmental Disorders
- Down syndrome and intellectual disability research
- interferon and immune responses
- Alzheimer's disease research and treatments
- Reproductive System and Pregnancy
- Mitochondrial Function and Pathology
- Developmental Biology and Gene Regulation
- RNA modifications and cancer
- Assisted Reproductive Technology and Twin Pregnancy
- Autism Spectrum Disorder Research
- Pluripotent Stem Cells Research
- Congenital heart defects research
- Axon Guidance and Neuronal Signaling
Centre Hospitalier Universitaire de Lille
2021-2025
Université de Lille
2021-2025
Inserm
2021-2025
Lille Neurosciences & Cognition
2021-2024
Centre de Recherche Jean Pierre Aubert
2024
University of Milan
2020-2023
IRCCS Istituto Auxologico Italiano
2020-2022
European Genomic Institute for Diabetes
2022
Istituti di Ricovero e Cura a Carattere Scientifico
2020
At the present time, no viable treatment exists for cognitive and olfactory deficits in Down syndrome (DS). We show a DS model (Ts65Dn mice) that these progressive nonreproductive neurological symptoms closely parallel postpubertal decrease hypothalamic as well extrahypothalamic expression of master molecule controls reproduction-gonadotropin-releasing hormone (GnRH)-and appear related to an imbalance microRNA-gene network known regulate GnRH neuron maturation together with altered...
We have recently demonstrated a causal link between loss of gonadotropin-releasing hormone (GnRH), the master molecule regulating reproduction, and cognitive deficits during pathological aging, including Down syndrome Alzheimer's disease. Olfactory alterations, which persist in some COVID-19 patients, long-term hypotestosteronaemia SARS-CoV-2-infected men are also reminiscent consequences deficient GnRH, suggesting that GnRH system neuroinvasion could underlie certain post-COVID symptoms...
Aging is the main risk factor of cognitive neurodegenerative diseases such as Alzheimer's disease, with epigenome alterations a contributing factor. Here, we compared transcriptomic/epigenomic changes in hippocampus, modified by aging and tauopathy, an AD-related feature. We show that cholesterol biosynthesis pathway severely impaired hippocampal neurons tauopathic but not aged mice pointing to vulnerability these disease. At epigenomic level, histone hyperacetylation was observed at...
Human reproduction is controlled by ~2000 hypothalamic gonadotropin-releasing hormone (GnRH) neurons. Here, we report the discovery and characterization of additional ~150,000–200,000 GnRH-synthesizing cells in human basal ganglia forebrain. Nearly all extrahypothalamic GnRH neurons expressed cholinergic marker enzyme choline acetyltransferase. Similarly, were also both embryonic adult brains. Whole-transcriptome analysis interneurons medium spiny projection laser-microdissected from putamen...
Polycystic ovary syndrome (PCOS), the most common endocrinopathy in women, causes significant reproductive and metabolic comorbidities, with no current cure. Gestational androgen anti-Müllerian hormone (AMH) excess are linked to PCOS, prenatal aberrant exposure these hormones induces PCOS-like traits animal models. However, whether AMH effects on PCOS programming could extend early postnatal life remains unknown. Clinical observations showed higher levels during minipuberty infants of...
To investigate predictors of testicular response and non-reproductive outcomes (height, body proportions) after gonadotropin-induced puberty in congenital hypogonadotropic hypogonadism (CHH). A retrospective analysis the induction CHH male patients, undergoing an off-label administration combined gonadotropin (FSH hCG). Clinical hormonal evaluations before during stimulation 19 patients genotyped by Targeted Next Generation Sequencing for genes; 16 underwent also semen gonadotropins. lesser...
<b><i>Introduction:</i></b> Gonadotropin-releasing hormone (GnRH) deficiency causes hypogonadotropic hypogonadism (HH), a rare genetic disorder that impairs sexual reproduction. HH can be due to defective GnRH-secreting neuron development or function and may associated with other clinical signs in overlapping syndromes. With most of the cases being idiopathic, genetics underlying is still largely unknown. <b><i>Objective:</i></b> To assess...
Hypothalamic gonadotropin-releasing hormone (GnRH) neurons lay the foundation for human development and reproduction; however, critical cell populations entangled mechanisms underlying of GnRH remain poorly understood. Here, by using our established pluripotent stem cell-derived neuron model, we decoded cellular heterogeneity differentiation trajectories at single-cell level. We found that a glutamatergic population, which generated together with neurons, showed similar transcriptomic...
Abstract Prokineticin receptors (PROKR1 and PROKR2) are G protein-coupled which control human central peripheral reproductive processes. Importantly, allelic variants of PROKR2 in humans associated with altered migration GnRH neurons, resulting congenital hypogonadotropic hypogonadism (CHH), a heterogeneous disease characterized by delayed/absent puberty and/or infertility. Although this association is established humans, murine models failed to fully recapitulate the olfactory phenotypes...
An amendment to this paper has been published and can be accessed via a link at the top of paper.
In vertebrate species, fertility is controlled by gonadotropin-releasing hormone (GnRH) neurons. GnRH cells arise outside the central nervous system, in developing olfactory pit, and migrate along olfactory/vomeronasal/terminal nerve axons into forebrain during embryonic development. Congenital hypogonadotropic hypogonadism (CHH) Kallmann syndrome are rare genetic disorders characterized infertility, they associated with defects neuron migration and/or altered secretion signaling. Here, we...
Abstract Human reproduction is controlled by ∼2,000 hypothalamic gonadotropin-releasing hormone (GnRH) neurons. Here we report the discovery and characterization of additional 150-200,000 GnRH-synthesizing cells in human basal ganglia forebrain. Extrahypothalamic GnRH neurons were cholinergic. Though undetectable adult rodents, GnRH-GFP transgene was expressed transiently caudate-putamen cholinergic interneurons newborn transgenic mice. In slice electrophysiological studies, inhibited these...
Abstract Neuroinvasion by SARS-CoV-2 is now accepted. To investigate whether low testosterone levels observed in men with severe COVID-19 could be of central origin, we retrospectively analyzed blood samples from 60 male intensive-care patients and explored brain entry using animal cellular models as well adult patient fetal human brains. Most hypotestosteronemic displayed hypogonadotropic hypogonadism or abnormal hypothalamic-pituitary-gonadal axis regulation. Neurons producing...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)