A5073440131- Uterine Myomas and Treatments
- Endometriosis Research and Treatment
- Gynecological conditions and treatments
- TGF-β signaling in diseases
- Estrogen and related hormone effects
- Plant Stress Responses and Tolerance
- Endometrial and Cervical Cancer Treatments
- Hemostasis and retained surgical items
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Plant Micronutrient Interactions and Effects
- Phytochemicals and Antioxidant Activities
- Enzyme Structure and Function
- Bone Tissue Engineering Materials
- Plant and soil sciences
- Omental and Epiploic Conditions
- Heavy metals in environment
- ATP Synthase and ATPases Research
- Chemical Synthesis and Analysis
- Aluminum toxicity and tolerance in plants and animals
- Hernia repair and management
- Metal Alloys Wear and Properties
- Endoplasmic Reticulum Stress and Disease
- Plant Disease Resistance and Genetics
- Heterotopic Ossification and Related Conditions
- Natural product bioactivities and synthesis
Academy of Scientific and Innovative Research
2025
Indian Institute of Integrative Medicine
2025
Council of Scientific and Industrial Research
2025
Lehigh Valley Hospital-Pocono
2025
Lehigh Valley Health Network
2025
Uniformed Services University of the Health Sciences
2015-2024
University Hospital Bratislava
2019
Slovak Medical University
2019
Comenius University Bratislava
2019
Detská Fakultná Nemocnica s Poliklinikou
2013
Commercially prepared grape (Vitis vinifera), bilberry (Vaccinium myrtillus L.), and chokeberry (Aronia meloncarpa E.) anthocyanin-rich extracts (AREs) were investigated for their potential chemopreventive activity against colon cancer. The growth of colon-cancer-derived HT-29 nontumorigenic colonic NCM460 cells exposed to semipurified AREs (10−75 μg monomeric anthocyanin/mL) was monitored up 72 h using a sulforhodamine B assay. All inhibited the cells, with ARE being most potent inhibitor....
Abstract Abstract: The aim of the present study was to investigate chemoprotective activity anthocyanin-rich extracts (AREs) from bilberry (Vaccinium myrtillus L.), chokeberry (Aronia meloncarpa E.), and grape (Vitis vinifera) by assessing multiple biomarkers colon cancer in male rats treated with a carcinogen, azoxymethane. Fischer 344 were fed AIN-93 diet (control) or supplemented AREs for 14 wk. Biomarkers that evaluated included number multiplicity colonic aberrant crypt foci (ACF), cell...
Abstract Anthocyanin-rich extracts, potent antioxidants and commercially available food coloring agents, have been reported to inhibit growth of various cancer cell lines. We investigated the effect semipurified anthocyanin-rich extract from fruits Aronia meloncarpa, on normal colon A 24-h exposure 50 µg monomeric anthocyanin/ml resulted in 60% inhibition human HT-29 cells. The treated cells showed a blockage at G1/G0 G2/M phases cycle. cycle arrest coincided with an increased expression...
Uterine leiomyomas are clinically significant tumours that may develop due to an altered differentiation pathway. We have previously identified a dysregulated retinoic acid (RA) pathway reduced exposure in human leiomyoma surgical specimens, and shown the phenotype was characterized by excessive disorganized extracellular matrix (ECM).The goal of this study determine impact RA on disrupted ECM leiomyomas.Study immortalized molecularly confirmed cells generated from specimens spontaneous...
A fundamental biologic principle is that diverse signals are channeled through shared signaling cascades to regulate development. Large scaffold proteins bind multiple capable of coordinating pathways provide specificity activation key developmental genes. Although much known about transcription factors and target genes cardiomyocyte differentiation, less couple at the cell surface differentiation in developing heart cells. Here we show AKAP13 (also as Brx-1, AKAP-Lbc, proto-Lbc), a unique...