A5061232265- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Phytoestrogen effects and research
- Frailty in Older Adults
- Genetics, Aging, and Longevity in Model Organisms
- Nutrition and Health in Aging
- Mesenchymal stem cell research
- Circular RNAs in diseases
- Vitamin C and Antioxidants Research
- Antioxidant Activity and Oxidative Stress
- Cardiovascular Disease and Adiposity
- Telomeres, Telomerase, and Senescence
- Nutritional Studies and Diet
- Adipose Tissue and Metabolism
- Mitochondrial Function and Pathology
- Sirtuins and Resveratrol in Medicine
- Intensive Care Unit Cognitive Disorders
- Nanoplatforms for cancer theranostics
- Tryptophan and brain disorders
- Helminth infection and control
- Hydrogen's biological and therapeutic effects
- Tissue Engineering and Regenerative Medicine
- Parasite Biology and Host Interactions
- Stress Responses and Cortisol
- Autophagy in Disease and Therapy
Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable
2017-2025
Universitat de València
2016-2025
Instituto de Salud Carlos III
2017-2025
Centro de Investigación Biomédica en Red
2018-2025
Albert Einstein College of Medicine
2025
INCLIVA Health Research Institute
2016-2023
University of Coimbra
2022
University of Perugia
2022
Centre for Biomedical Network Research on Rare Diseases
2017-2018
Aging is associated with an increased risk of frailty, disability, and mortality. Strategies to delay the degenerative changes aging frailty are particularly interesting. We treated old animals small extracellular vesicles (sEVs) derived from adipose mesenchymal stem cells (ADSCs) young animals, we found improvement in several parameters usually altered aging, such as motor coordination, grip strength, fatigue resistance, fur regeneration, renal function, well important decrease frailty....
Amyloid-β (Aβ) clearance from brain, which is decreased in Alzheimer's disease, facilitated by apolipoprotein E (ApoE). ApoE upregulated activation of the retinoid X receptor moiety RXR/PPARγ dimeric receptor. Genistein, a non-toxic, well-tested, and inexpensive drug activates o ther PPARγ. Treatment an disease mouse model with genistein results remarkable rapid improvement various parameters cognition, such as hippocampal learning, recognition memory, implicit odor discrimination. This...
Females live longer than males, and the estrogens are one of reasons for this difference. We reported some years ago that able to protect rats against oxidative stress, by inducing antioxidant genes. Type 2 diabetes is an age-associated disease in which stress involved, moreover, studies show prevalence higher men women, therefore there sex-associated differences. Thus, aim study was evaluate role protecting type diabetic males females. For purpose, we used Goto-Kakizaki rats, develop with...
LRP1-targeted St-Cl–polyglutamate conjugates as multivalent neuroprotective/neurotrophic therapeutics for Alzheimer’s disease.
Human dental pulp stem cells (hDPSCs) are a source for cell therapy. Before implantation, an in vitro expansion step is necessary, with the inconvenience that hDPSCs undergo senescence following certain number of passages, loosing their stemness properties. Long-term culture at 21% (ambient oxygen tension) compared 3–6% tension (physiological caused oxidative stress-related premature senescence, as evidenced by increased β-galactosidase activity and lysil oxidase expression, which mediated...
Abstract Human fascioliasis is a worldwide, pathogenic food-borne trematodiasis. Impressive clinical pictures comprising puzzling polymorphisms, manifestation multifocality, disease evolution changes, sequelae and mortality, have been reported in patients presenting with neurological, meningeal, neuropsychic ocular disorders caused at distance by flukes infecting the liver. Proteomic mass spectrometry analyses of Fasciola hepatica excretome/secretome identified numerous, several new,...
Aging is accompanied by the accumulation of senescent cells that alter intercellular communication, thereby impairing tissue homeostasis and reducing organ regenerative potential. Recently, administration mesenchymal stem (MSC)-derived extracellular vesicles has proven to be more effective less challenging than current cell-based therapies. Extracellular (EVs) contain a cell-specific cargo proteins, lipids nucleic acids are released taken up probably all cell types, inducing functional...
The objective of this work was to determine the specific mechanisms by which resveratrol inhibits lipogenesis and stimulates lipolysis.Twelve male mice were individually introduced into a metabolic cage for 24 h measure basal rate, prior intervention. They randomly divided two groups, (RSV) control (C), administered intraperitoneally or vehicle, respectively, consecutive days. After h, energy expenditure again determined before sacrificed. Protein gene expression different enzymes related...
Extracellular vesicles' biogenesis, shedding, and uptake are redox-sensitive. Indeed, oxidative stress conditions influence extracellular release content, which can modulate the redox status of receiving cells. In this study, we aimed to assess effect vesicles from human dental pulp stem cells cultured under 21% O2 (senescent cells) on 3% (young cells). were isolated by ultracentrifugation senescent prepared for treatment young at a final concentration 10 μg/mL. Cells analyzed antioxidant...
High rates of stem cell proliferation are important in regenerative medicine and banking for clinical use. Ambient oxygen tensions (21% O2) normally used vitro culture, but physiological levels vivo range between 3% 6% O2. We compared human dental pulp cells (hDPSCs) cultured under 21% versus The rate hDPSC is significantly lower at O2 to due enhanced oxidative stress. Under O2, increased p38 phosphorylation led activation p21. Increased generation reactive species p21 the NRF-2 signaling...