A5019120886- Ion channel regulation and function
- Cardiac electrophysiology and arrhythmias
- Receptor Mechanisms and Signaling
- Cardiomyopathy and Myosin Studies
- Acute Lymphoblastic Leukemia research
- Electrochemical Analysis and Applications
- Ubiquitin and proteasome pathways
- Congenital heart defects research
- Neuroscience and Neuropharmacology Research
- Lymphoma Diagnosis and Treatment
University of Oslo
2021-2023
Oslo University Hospital
2021-2023
Institutt for Eksperimentell Medisinsk Forskning
2021-2023
Centre National de la Recherche Scientifique
2021
Université Grenoble Alpes
2021
Inserm
2021
Background: The sarcoplasmic reticulum (SR) Ca 2+ -ATPase 2 (SERCA2) mediates reuptake into SR and thereby promotes cardiomyocyte relaxation, whereas the ryanodine receptor (RYR) release from triggers contraction. /CaMKII (CaM [calmodulin]-dependent protein kinase II) regulates activities of SERCA2 through phosphorylation PLN (phospholamban) RYR direct phosphorylation. However, mechanisms for CaMKIIδ anchoring to SERCA2-PLN its regulation by local signals remain elusive. objective this study...
Transverse tubules (t-tubules) form gradually in the developing heart, critically enabling maturation of cardiomyocyte Ca2+ homeostasis. The membrane bending and scaffolding protein BIN1 (bridging integrator 1) has been implicated this process. However, it is unclear which various reported isoforms are involved, whether function regulated by its putative binding partners MTM1 (myotubularin), a phosphoinositide 3'-phosphatase, DNM2 (dynamin-2), GTPase believed to mediate fission.We...
Ryanodine receptors (RyRs) exhibit dynamic arrangements in cardiomyocytes, and we previously showed that ‘dispersion’ of RyR clusters disrupts Ca 2+ homeostasis during heart failure (HF) (Kolstad et al., eLife, 2018). Here, investigated whether prolonged β-adrenergic stimulation, a hallmark HF, promotes cluster dispersion examined the underlying mechanisms. We observed treatment healthy rat cardiomyocytes with isoproterenol for 1 hr triggered progressive fragmentation clusters....
R-CHOP immuno-chemotherapy significantly improved clinical management of diffuse large B-cell lymphoma (DLBCL). However, 30-40% DLBCL patients still present a refractory disease or relapse. Most the prognostic markers identified to date fail accurately stratify high-risk patients. We have previously shown that nuclear protein CYCLON is associated with progression and resistance anti-CD20 immunotherapy in preclinical models. also recently reported it represents potent predictor relapse...
Abstract Ryanodine Receptors (RyRs) exhibit dynamic arrangements in cardiomyocytes, and we previously showed that “dispersion” of RyR clusters disrupts Ca 2+ homeostasis during heart failure (HF) (Kolstad et al ., eLife, 2018). Here, investigated whether prolonged β-adrenergic stimulation, a hallmark HF, promotes cluster dispersion, examined the underlying mechanisms. We observed treatment healthy rat cardiomyocytes with isoproterenol for 1 hour triggered progressive fragmentation clusters....