Christine Lefebvre

ORCID: 0000-0003-0424-3731
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About
Contact & Profiles
Research Areas
  • Chronic Lymphocytic Leukemia Research
  • Lymphoma Diagnosis and Treatment
  • Acute Myeloid Leukemia Research
  • Acute Lymphoblastic Leukemia research
  • Chronic Myeloid Leukemia Treatments
  • Immunodeficiency and Autoimmune Disorders
  • Viral-associated cancers and disorders
  • Cancer Genomics and Diagnostics
  • Lung Cancer Treatments and Mutations
  • Protein Degradation and Inhibitors
  • Reproductive Biology and Fertility
  • Breast Cancer Treatment Studies
  • S100 Proteins and Annexins
  • Ubiquitin and proteasome pathways
  • Endometriosis Research and Treatment
  • Hematological disorders and diagnostics
  • Ovarian function and disorders
  • CAR-T cell therapy research
  • Blood disorders and treatments
  • Inflammatory Bowel Disease
  • Uterine Myomas and Treatments
  • Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Systemic Lupus Erythematosus Research
  • Advanced Breast Cancer Therapies
  • Myeloproliferative Neoplasms: Diagnosis and Treatment

Centre Hospitalier Universitaire de Grenoble
2014-2024

Université Grenoble Alpes
2009-2024

Centre National de la Recherche Scientifique
2016-2024

Inserm
2012-2024

McGill University
2024

Université de Rouen Normandie
2023

Servier (France)
2023

Groupe Francophone des Myélodysplasies
2016-2022

Institut de Recherche et d’Innovation
2022

Centre hospitalier régional de la Citadelle
2010-2021

<h3>Objectives:</h3> Genetic susceptibility is known to play a large part in the predisposition inflammatory bowel diseases (IBDs) as Crohn's disease (CD) and ulcerative colitis (UC). The <i>IL2/IL21</i> locus on 4q27 be common risk for (shown coeliac disease, type 1 diabetes, rheumatoid arthritis, systemic lupus erythematosus psoriasis), while roles that interleukin 2 (IL2) IL21 immune response also make them attractive candidates IBD. objective of this study was test association between...

10.1136/gut.2008.166918 article EN Gut 2009-02-06

Background: Skin painting (pseudotattooing) with henna is traditionally performed mainly in Muslim or Hindu persons.Recently, transient artists have begun using black mixtures to temporarily paint the skin.Emergence of allergic contact dermatitis after application indicates presence a skin sensitizer such preparations and poses future risks.Observations: Four patients developed France, Egypt, United States.The delay symptoms suggested previous sensitization 1 patient active 3 patients.Of who...

10.1001/archderm.136.12.1515 article EN Archives of Dermatology 2000-12-01

Carbamazepine is a potent anticonvulsivant, but, irregular plasma levels are noticed. The variability of therapeutic efficiency can be attributed to interindividual sensibility, chronobiologic effect, but also rates dissolution which differ when polymorphs induced by technologic operations.Several crystalline forms have been characterized. As for us, we studied three modifications found in commercialized galenic forms: the most usual beta form, alpha form and dihydrate.The aim this work was...

10.3109/03639048609042617 article EN Drug Development and Industrial Pharmacy 1986-01-01

Summary Immunological studies have supported the idea that innate immunity is critical for control of Mycobacterium tuberculosis ( Mtb ) infection in humans. Despite overwhelming evidence showing role Toll‐like receptors (TLRs) vitro recognition , vivo significance individual TLRs has been more difficult to demonstrate consistently. We were interested examining genes and molecules involved their signalling cascades, a case–control study was designed test association polymorphisms these...

10.1111/j.1744-313x.2011.01077.x article EN International Journal of Immunogenetics 2012-01-05

Anemia is a frequent cytopenia in myelodysplastic syndromes (MDS) and most patients require red blood cell transfusion resulting iron overload (IO). Deferasirox (DFX) has become the standard treatment of IO MDS it displays positive effects on erythropoiesis. In low risk samples, mechanisms improving erythropoiesis after DFX remain unclear. Herein, we addressed this question by using liquid cultures with erythroid precursors treated dose (3μM), which corresponds to 5 mg/kg/day, an unusual...

10.18632/oncotarget.22299 article EN Oncotarget 2017-11-06
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