A5104779419- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Acute Myeloid Leukemia Research
- Viral-associated cancers and disorders
- Chronic Myeloid Leukemia Treatments
- Acute Lymphoblastic Leukemia research
- Immunodeficiency and Autoimmune Disorders
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Multiple Myeloma Research and Treatments
- CAR-T cell therapy research
- Genomic variations and chromosomal abnormalities
- Immune Cell Function and Interaction
- Blood disorders and treatments
- Eosinophilic Disorders and Syndromes
- Neuroblastoma Research and Treatments
- Sarcoma Diagnosis and Treatment
- Kruppel-like factors research
- Monoclonal and Polyclonal Antibodies Research
- Cancer Genomics and Diagnostics
- Histone Deacetylase Inhibitors Research
- Neutropenia and Cancer Infections
- Cancer therapeutics and mechanisms
- Glycosylation and Glycoproteins Research
- Hematological disorders and diagnostics
- Protein Degradation and Inhibitors
Laboratoire National Henri Becquerel
2010-2024
Centre Henri Becquerel
2009-2024
Inserm
2007-2024
Université de Rouen Normandie
2012-2024
Centre Virchow-Villermé
2008-2023
Groupe Francophone des Myélodysplasies
2016-2021
Hudson Institute
2019
John Wiley & Sons (United States)
2019
Biologie Labor
2002
Institut Curie
2000
Waldenström's macroglobulinemia is a disease of mature B cells, the genetic basis which poorly understood. Few recurrent chromosomal abnormalities have been reported, and their prognostic value not known. We conducted prospective cytogenetic study examined aberrations in an international randomized trial. The main were 6q deletions (30%), trisomy 18 (15%), 13q (13%), 17p (TP53) (8%), 4 11q (ATM) (7%). There was significant association between chromosome 18. Translocations involving IGH genes rare (
CD38 expression and chromosomal abnormalities are novel prognostic factors in chronic lymphocytic leukaemia (CLL). However, their value remains undetermined. was evaluated 123 patients aberrations 111 cases with fluorescence situ hybridization (FISH). found 27% of the cases. In addition, seven out 32 CD38- became CD38+ during evolution disease. Chromosomal included isolated 13q deletion (40%), 12q trisomy (14%), 11q (without 17p deletion) (14%) (7%). significantly associated Binet stages B...
Abstract TP53 mutations are frequent in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) with complex karyotype that include del(5q) often associated deletion of 17p. They have also recently been observed MDS isolated del(5q). We assessed the incidence 17p detected by fluorescence situ hybridization (FISH) direct sequencing their correlation prognostic value 26 17 AML In 20 cases or one additional abnormality, no was found 3 18 analyzed (17%) had mutation. 23 patients...
Mantle cell lymphoma (MCL) is usually an aggressive disease. However, a few patients do have “indolent” evolution (iMCL) defined by long survival time without intensive therapy. Many studies highlight the prognostic role of additional genetic abnormalities, but these abnormalities are not routinely tested for and yet influence treatment decision. We aimed to evaluate impact detected conventional cytogenetic testing, as well their relationships with clinical characteristics value in...
Abstract Primary mediastinal B-cell lymphoma (PMBL) is an uncommon entity of aggressive with unusually good prognosis, except for 10-15% chemotherapy-refractory cases. To identify earlier these higher risk patients, we performed molecular characterization a retrospective multicenter cohort patients treated firstline immunochemotherapy. The traits the gene-expression profiling data (n = 120) were as follows: median age 34 years (range, 18-67 years); female sex, 58.3%; elevated lactate...
// Sydney Dubois 1 , Sylvain Mareschal Jean-Michel Picquenot 1, 2 Pierre-Julien Viailly Elodie Bohers Marie Cornic Philippe Bertrand Elena Liana Veresezan Ruminy Catherine Maingonnat Vinciane Marchand Hélène Lanic 3 Dominique Penther Christian Bastard Hervé Tilly Fabrice Jardin INSERM U918, Centre Henri Becquerel, Université de Rouen, IRIB, France Department of Pathology, Clinical Hematology, Correspondence to: Jardin, e-mail: fabrice.jardin@chb.unicancer.fr Keywords: DLBCL, EZH2,...
Summary Dysregulation of MYC is the genetic hallmark Burkitt lymphoma ( BL ) but it encountered in other aggressive mature B‐cell lymphomas. dysregulation needs cooperating events for development. We aimed to characterize these and assess differences between adult paediatric s that may explain different outcomes two populations. analysed patterns aberrations a series 24 BLs: 11 adults 13 children. looked genomic imbalances (copy number variations), copy‐neutral loss heterozygosity CN ‐ LOH...
Flow cytometry allows specific assessment of the expression ZAP-70, a promising new prognostic factor in B-cell chronic lymphocytic leukemia (B-CLL), but suffers from lack multicenter standardization.An optimized method for direct detection ZAP-70 flow was tested fashion. Adapted frozen cells, this includes normalization step by addition B cells pool peripheral blood mononuclear collected normal donors. levels were assessed 153 patients with typical leukemia. Results expressed as ratio mean...
In B-cell acute lymphoblastic leukemia (B-ALL), testing at diagnosis for BCR/ABL1 gene rearrangements is mandatory prognostic stratification and treatment decisions. Several diagnostic methods have been proposed using flow cytometry to identify BCR/ABL1(+) B-ALL.We evaluated expression of the myeloid antigen CD66c by in B-ALL. We studied 94 patients with The t(9;22)(q34;q11) or rearrangement was detected cytogenetic analysis RT/PCR. Myeloid antigens CD66c, CD13, CD33, CD117, Myeloperoxidase,...
Complete or partial gain of the long arm chromosome 17 (17q) has been shown recently by molecular cytogenetic techniques to be most frequent chromosomal change in neuroblastoma and associated with adverse prognosis. Few reports, however, have focused on precise mapping commonly overrepresented region. We investigated 17q analysis allelic imbalances at microsatellite loci dispersed along a series 69 neuroblastomas. Allelic for least two consecutive were observed 39/59 informative cases, that...
Abstract We previously showed that complex karyotypes (CK) and chromosome 13q abnormalities have an adverse prognostic impact in childhood Burkitt lymphomas/leukemias (BL) diffuse large B‐cell lymphomas (DLBCL). The aim of our study was to identify recurrent alterations associated with MYC rearrangements aggressive CK. Multicolor fluorescence situ hybridization (M‐FISH) performed 84 patient samples (59 adults 25 children), including 37 BL (13 24 acute leukemias), 12 DLBCL, 28 intermediate...
Evolution to myelofibrosis (MF), acute myeloid leukemia or myelodysplastic syndrome (AML/MDS) may occur over time in myeloproliferative neoplasms (MPN) patients most likely due the acquisition of additional mutations. The Groupe Francophone de cytogenetique hematologique (GFCH) has collected and reviewed 82 with transformation MPN (66 AML/MDS 16 MF). JAK2V617F TET2 mutations were searched for 40 32 patients, respectively. Significantly more -7/del(7q) (P = 0.004) -5/del(5q) 0.03) found a...
Chronic lymphocytic leukemia (CLL) with 17p deletion (17p-) is associated a lack of response to standard treatment and thus the worst possible clinical outcome. Various chromosomal abnormalities (including unbalanced translocations, deletions, ring chromosomes isochromosomes) result in loss one copy TP53 gene. The objective present study was determine whether type abnormality leading 17p- additional aberrations influenced prognosis series 195 patients 17p-CLL. Loss resulted primarily from an...
Clonal chromosome abnormalities in Philadelphia-negative cells could concern chronic myeloid leukemia patients treated by tyrosine kinase inhibitors. The European LeukemiaNet distinguishes -7/del(7q) as a "warning". However, the impact of clonal abnormalities, and specifically those -7/del(7q), on clinical outcomes is unclear based case-reports showing morphological dysplasia increased risk acute leukemia, suggesting coexistence high-risk myelodysplastic syndrome. aim this study was to...
Patients with NPM1-mutated AML M5 who develop spontaneous remission (SR) after antibiotic therapy at diagnosis seem to form a favorable prognosis and chemo sensitive subtype. We report three cases of patients the same genotype that experienced transient SR are now leukemia free standard treatment.