A5036437858- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Immunodeficiency and Autoimmune Disorders
- Glioma Diagnosis and Treatment
- CNS Lymphoma Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Viral-associated cancers and disorders
- Psychopathy, Forensic Psychiatry, Sexual Offending
- Hepatitis C virus research
- Acute Lymphoblastic Leukemia research
- CAR-T cell therapy research
- Glycosylation and Glycoproteins Research
- Chronic Myeloid Leukemia Treatments
- Acute Myeloid Leukemia Research
- Healthcare Decision-Making and Restraints
- Criminal Justice and Corrections Analysis
- Epigenetics and DNA Methylation
- T-cell and B-cell Immunology
- Animal Disease Management and Epidemiology
- Tuberculosis Research and Epidemiology
- T-cell and Retrovirus Studies
- Vector-Borne Animal Diseases
- Schizophrenia research and treatment
- Histiocytic Disorders and Treatments
- Venous Thromboembolism Diagnosis and Management
Sorbonne Université
2016-2025
Assistance Publique – Hôpitaux de Paris
2015-2025
Pitié-Salpêtrière Hospital
2015-2025
Inserm
2000-2024
Centre de Recherche des Cordeliers
2017-2023
Institut Gustave Roussy
2019-2020
La Ligue Contre le Cancer
2018-2019
Université Paris-Saclay
2018-2019
Centre National de la Recherche Scientifique
2017-2018
Hôpital Charles-Foix
2017
Abstract TET2 somatic mutations occur in ∼10% of diffuse large B-cell lymphomas (DLBCL) but are unknown significance. Herein, we show that is required for the humoral immune response and a DLBCL tumor suppressor. loss function disrupts transit B cells through germinal centers (GC), causing GC hyperplasia, impaired class switch recombination, blockade plasma cell differentiation, preneoplastic phenotype. was linked to focal enhancer hydroxymethylation transcriptional repression genes mediate...
There is a wealth of studies somatic and mental illness among prisoners, but little on older prisoners their cognitive aging.Our study examines the performance male its effect perceived health quality life.A total 138 men aged 50 or over were recruited in seven French prisons similar ages from general population. Two assessments executive functions - mini-mental state examination frontal assessment battery administered to each participant, together with self rating schedules (Nottingham...
While Waldenström macroglobulinemia (WM) is characterized by an almost unifying mutation in MYD88, clinical presentation at diagnosis and response to therapy can be widely different among WM patients. Current prognostic tools only partially address this heterogeneity. Limited data compiling both molecular cytogenetic information have been used risk prognostication WM. To investigate the impact of genetic alterations WM, we evaluated abnormalities chromosome banding analyses, FISH targeted...
Summary Diagnosis of primary central nervous system lymphoma (PCNSL) is challenging, and although brain biopsy remains the gold standard, cerebrospinal fluid (CSF) constitutes a less invasive source lymphomatous biomarkers. In retrospective cohort 54 PCNSL cases tested at diagnosis or relapse, we evaluated contribution immunoglobulin heavy chain (IGH) gene clonality MYD88 L265P detection on both CSF cell pellets supernatants, in comparison with cytology, flow cytometry, interleukin (IL)‐10...
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<div>Abstract<p>The ETS-domain transcription factors divide into subfamilies based on protein similarities, DNA-binding sequences, and interaction with cofactors. They are regulated by extracellular clues contribute to cellular processes, including proliferation transformation. <i>ETS</i> genes targeted through genomic rearrangements in oncogenesis. The <i>PU.1/SPI1</i> gene is inactivated point mutations human myeloid malignancies. We identified a...
The ETS-domain transcription factors divide into subfamilies based on protein similarities, DNA-binding sequences, and interaction with cofactors. They are regulated by extracellular clues contribute to cellular processes, including proliferation transformation. ETS genes targeted through genomic rearrangements in oncogenesis. PU.1/SPI1 gene is inactivated point mutations human myeloid malignancies. We identified a recurrent somatic mutation (Q226E) Waldenström macroglobulinemia, B-cell...
ABSTRACT Polymorphisms along the hepatitis B virus (HBV) genome have an impact on disease outcome, sensitivity to antiviral treatment, escape from vaccination, and laboratory diagnosis. We designed a diagnostic tool based duplex amplification of whole HBV high-density DNA chip detect 245 mutations, 20 deletions, 2 insertions at 151 positions determine genotype in serum. Assay performances were evaluated with 170 samples, characterized by determination viral load sequencing Pol, S, precore...
Infiltration of the peripheral nervous system (PNS) by lymphoma, called neurolymphomatosis, is a rare condition among spectrum lymphoma-associated neuropathies; its diagnosis challenging. Cerebrospinal fluid (CSF) analysis great value, but nerve biopsy (NB) may be necessary to prove invasion malignant cells. Clonality polymerase chain reaction (PCR)-based validated method in hematological malignancies, there are very little data on diagnostic yield NB samples. We explored contribution with...
The aim of our study was to identify psychiatric and cognitive disorders among older prison inmates investigate whether there is an association between mental impairment. 138 men aged 50 over were recruited in seven French prisons (Group 1) from the general public 2). Participants assessed using Mini International Neuropsychiatric Interview, Mental State Examination, Frontal Assessment Battery. results reveal very significant differences incidence performance two groups. However, does not...
Next-generation sequencing (NGS) has transitioned from research to clinical routine, yet the comparability of different technologies for mutation profiling remains an open question. We performed a European multicenter (n=6) evaluation three amplicon-based NGS assays targeting 11 genes recurrently mutated in chronic lymphocytic leukemia. Each assay was assessed by two centers using 48 pre-characterized leukemia samples; libraries were sequenced on Illumina MiSeq instrument and bioinformatics...
Chronic lymphocytic leukemia (CLL) with 17p deletion (17p-) is associated a lack of response to standard treatment and thus the worst possible clinical outcome. Various chromosomal abnormalities (including unbalanced translocations, deletions, ring chromosomes isochromosomes) result in loss one copy TP53 gene. The objective present study was determine whether type abnormality leading 17p- additional aberrations influenced prognosis series 195 patients 17p-CLL. Loss resulted primarily from an...
T-cell Receptor Gamma (TRG) rearrangements are commonly used to detect clonal lymphoproliferations in hematopathology, since they rearranged virtually all T lymphocytes and have a relatively limited recombinatorial repertoire, which reduces the risk of false negative results, at cost potential positivity. We developed an initial one-tube, 2-fluorochrome EuroClonality TRG PCR multiplex (TRG-1T-2F) was compared original 2-tube, EuroClonality/BIOMED-2 (TRG-2T-2F) commercial Invivoscribe...