A5060762791- Blood groups and transfusion
- Erythrocyte Function and Pathophysiology
- Hemoglobinopathies and Related Disorders
Durban University of Technology
2021
South African National Blood Service
2017-2021
BACKGROUND Only a few genetic variants have been reported in regulatory elements of blood group genes. Most them affect GATA motifs, binding sites for the GATA‐1 transcription factor. STUDY DESIGN AND METHODS Samples from two patients and one donor with unusual or discrepant serology ABO, RhD, RhCE antigens were analyzed by DNA sequencing. Analyzed regions included coding sequence portions elements. The effect some on gene expression was evaluated reporter assays. RESULTS Three new alleles...
Molecular red cell genotyping is devoid of serology limitations such as the scarcity rare antisera and possibility inconclusive results due to biological interferences. Blood incompatibility can result in immune transfusion reactions haemolytic or disease foetus newborn.The study aimed use molecular identify blood group donors among South African donors.Red data were extracted retrospectively from BIDS XT software Immunohaematology Reference Laboratory January 2015 August 2016. The ID CORE...