A5067164645- Cardiac Fibrosis and Remodeling
- Peptidase Inhibition and Analysis
- Heat shock proteins research
- Advanced biosensing and bioanalysis techniques
- Tendon Structure and Treatment
- Cardiomyopathy and Myosin Studies
- Signaling Pathways in Disease
- Cancer-related gene regulation
- ATP Synthase and ATPases Research
- Systemic Sclerosis and Related Diseases
- Advanced Electron Microscopy Techniques and Applications
- Protease and Inhibitor Mechanisms
- Advanced X-ray Imaging Techniques
- Tissue Engineering and Regenerative Medicine
- Cardiac Imaging and Diagnostics
- Extracellular vesicles in disease
Universidad de Cantabria
2018-2025
Instituto de Biomedicina y Biotecnología de Cantabria
2018-2022
Instituto de Investigación Marqués de Valdecilla
2021-2022
Consejo Superior de Investigaciones Científicas
2022
Abstract Cardiac fibrosis is a key characteristic of heart failure, with no effective treatment available. Using three-dimensional human models and cutting-edge biotechnology to evaluate new therapies offers significant advancement. CTPR390, an experimental anti-fibrotic inhibitor targeting Hsp90, has shown success in animal models, but remains unexplored cardiac models. This study evaluated engineered connective tissue (ECT) model treated focusing on changes the extracellular matrix...
Engineering protein-based hybrids by combining protein engineering and nanotechnology: a protein-nanocluster hybrid for theranostic use in myocardial fibrosis shows the potential to create tailored multifunctional biologics biomedicine.
Revealing the intracellular location of novel therapeutic agents is paramount for understanding their effect at cell ultrastructure level. Here, we apply a correlative cryo 3D imaging approach to determine fate designed protein-nanomaterial hybrid with antifibrotic properties that shows great promise in mitigating myocardial fibrosis. Cryo structured illumination microscopy (cryo-3D-SIM) pinpoints and soft X-ray tomography (cryo-SXT) reveals ultrastructural environment subcellular...
Abstract Systemic sclerosis (SSc) is an autoimmune disease that affects skin and multiple internal organs. TGF-β, a central trigger of cutaneous fibrosis, activates fibroblasts with the involvement stress-inducible chaperone heat shock protein 90 isoform α (Hsp90α). Available evidence supports overexpression secretion Hsp90α as feature in profibrotic pathological conditions. The aim this work to investigate expression function experimental models fibrosis such human fibroblasts, C57BL/6...