A5052007080- Solid State Laser Technologies
- Cancer Immunotherapy and Biomarkers
- Luminescence Properties of Advanced Materials
- Oil and Gas Production Techniques
- Gold and Silver Nanoparticles Synthesis and Applications
- Renal cell carcinoma treatment
- Pancreatic and Hepatic Oncology Research
- Spectroscopy and Quantum Chemical Studies
- Electrostatics and Colloid Interactions
- Hydrological Forecasting Using AI
- Laser Design and Applications
- Signaling Pathways in Disease
- Drilling and Well Engineering
- Microbial infections and disease research
- Innovative Microfluidic and Catalytic Techniques Innovation
- Fatty Acid Research and Health
- Cancer, Lipids, and Metabolism
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Diffusion and Search Dynamics
- Phagocytosis and Immune Regulation
- Parathyroid Disorders and Treatments
- Plant tissue culture and regeneration
- Clinical Reasoning and Diagnostic Skills
- Plant Pathogens and Fungal Diseases
- Cardiac Fibrosis and Remodeling
Brigham and Women's Hospital
2025
Donostia International Physics Center
2025
University of South Florida
2024
Petrobras (Brazil)
2014-2023
Universidade Estadual de Campinas (UNICAMP)
2019-2022
University Hospitals of Cleveland
2021
Universidade Federal de Minas Gerais
2019
Abstract Cardiac fibrosis is a key characteristic of heart failure, with no effective treatment available. Using three-dimensional human models and cutting-edge biotechnology to evaluate new therapies offers significant advancement. CTPR390, an experimental anti-fibrotic inhibitor targeting Hsp90, has shown success in animal models, but remains unexplored cardiac models. This study evaluated engineered connective tissue (ECT) model treated focusing on changes the extracellular matrix...
590 Background: Inhibition of PD-1 signaling in regulatory T cells (Tregs) has been shown to enhance their immunosuppressive function. We previously demonstrated that high levels expression on tumor-infiltrating Tregs are associated with resistance nivolumab (nivo) monotherapy pretreated patients advanced clear cell renal carcinoma (ccRCC) from the CheckMate-025 trial (Denize et al, 2024). Here, we aim validate these findings first-line setting. Methods: Primary tumor tissues ccRCC (n=70)...
Abstract The growing demand for downhole chemical injection, in addition to deeper offshore wells, brings new challenges controlling injection flow rates. best way of facing these and avoiding the known problems that spoil efficiency is a proper design systems. A good requires modelling fluids physical properties, fair estimate fluid temperature profile, assessment equipment performance evaluation transient effects. Tubing pressure oscillations (caused by well production instability or...
Most electrochemical processes occur in the electrode-solution interface, thus, understanding structure and dynamic of electric double layer is mandatory for development field its related technologies. Herein, we present an apparatus <i>in situ </i>ultrafast dynamics low-frequency stimulated Raman spectroscopy measurements interface by time-resolved optical Kerr effect spectroscopy. We give details laser system, spectroelectrochemcial cell, calibration integrated setup. studied as a function...
Residual inflammation drives atherogenesis to atherosclerosis and myocardial infarction, which triggers acute inflammation. In preclinical studies, polyunsaturated fatty acids-derived specialized pro-resolving mediators (SPMs) have been shown promote recovery after MI, in contrast pro-inflammatory lipid (PIMs). However, the dynamic changes of ST-elevation infarction (STEMI), particularly percutaneous coronary intervention (PCI) respective gene transcripts, are poorly understood. Therefore,...
Abstract This work presents the results of several failure analyses gas lift valves retrieved from Petrobras subsea wells. These were unable to prevent backflow tubing annulus, so compromising well integrity. The purpose these was unveil root causes failure, which is essential information its recurrence. When a tubing-annulus communication detected and damaged valve identified as cause problem, transported workshop preserving much possible conditions found when it came out well, allowing...
We use a simple model of particle shape to investigate how asymmetry affects particle-surface interaction, orientation, and stochastic dynamics over planar surface. With this geometric model, we construct potential energy curves as function orientation relative the surface, identify minimum for particles various shapes ranging from symmetric (sphere) asymmetric (oval-shaped). The calculated difference between centroid position location is used define an offset, which useful comparison with...
A proposta dessa pesquisa foi levantar e reunir dados de isolamento sonoro aéreo partições verticais diferentes materiais sistemas construtivos utilizados na construção civil brasileira também identificar testar ferramentas computacionais para predição deste isolamento. Para isso, o projeto divido em duas etapas: a primeira voltada (tanto laboratório como campo) segunda buscando desse Em ambas as partes busca realizada portais científicos especializados como: Web of Science, Scopus,...