A5067526225- Breast Cancer Treatment Studies
- Global Cancer Incidence and Screening
- Muscle Physiology and Disorders
- Health Promotion and Cardiovascular Prevention
- Cardiovascular Health and Risk Factors
- Clinical practice guidelines implementation
- Genetics, Aging, and Longevity in Model Organisms
- Intracranial Aneurysms: Treatment and Complications
- Nerve injury and regeneration
- Genetic factors in colorectal cancer
- Frailty in Older Adults
- Folate and B Vitamins Research
- Neurogenetic and Muscular Disorders Research
- Chronic Disease Management Strategies
- Organophosphorus compounds synthesis
- Cancer survivorship and care
- Proteoglycans and glycosaminoglycans research
- Cell Adhesion Molecules Research
- TGF-β signaling in diseases
- Spinal Cord Injury Research
- Genetic Neurodegenerative Diseases
- biodegradable polymer synthesis and properties
- Colorectal Cancer Screening and Detection
- Tissue Engineering and Regenerative Medicine
- Axon Guidance and Neuronal Signaling
Office for Health Improvement and Disparities
2023
Healthcare Quality Improvement Partnership
2023
Public Health England
2014-2021
Philips (United Kingdom)
2016
West Midlands Police
2006-2013
University of Birmingham
2000-2009
Queen Elizabeth Hospital Birmingham
2002
Université Paris-Est Créteil
1993-1998
Laboratoire de Recherche sur la Croissance Cellulaire, la Réparation et la Régénération Tissulaires
1993-1998
Université Paris Cité
1996
Objectives To describe the uptake and outputs of National Health Service Check (NHSHC) programme in England. Design Observational study. Setting primary care data extracted directly by NHS Digital from 90% general practices (GP) Participants Individuals aged 40–74 years, invited to or completing a NHSHC between 2012 2017, defined using Read codes. Intervention The NHSHC, structured assessment non-communicable disease risk factors 10-year cardiovascular (CVD) risk, with recommendations for...
Chronic communicating hydrocephalus is a common sequela of subarachnoid haemorrhage and develops when the flow drainage CSF are impaired after fibrosis in space. Released by platelets into haemorrhage, transforming growth factor (TGF)beta1/beta2 potent fibrogenic agents that may promote post-haemorrhagic chronic hydrocephalus.Temporal changes total (latent plus active) TGFbeta1/beta2 levels post-haemorrhage patients developing acute were measured using ELISA to discover if titres higher...
Objective A modified version of the Joint British Societies (JBS3) ‘heart age’ tool was introduced online to broaden access personalised risk assessment general population and encourage participation in National Health Service (NHS) Check programme. This study reports on its early uptake profiles those who used self-assessment determine their own cardiovascular risk. Design Observational, retrospective analysis use. Setting Between February July 2015, user data collected from NHS Choices...
Transforming growth factor-beta1 (TGF-beta1) is a fibrogenic cytokine that involved in postinjury repair and implicated the etiology of postsubarachnoid hemorrhage (SAH) chronic communicating hydrocephalus. TGF-beta1 was measured by enzyme-linked immunosorbant assay (ELISA) sequential samples cerebrospinal fluid (CSF) 11 patients with hydrocephalus after SAH; levels were seen to be biphasically elevated sources investigated. compared albumin estimated CSF blood content. Control from...
Data collection for screen-detected breast cancer in the United Kingdom is fully funded, which has led to improvements clinical practice. However, data on symptomatic are deficient, and aim of this project was monitor current A set designed together with surrogate outcome measures reflect best from registries initially required consent clinicians, but third year anonymised were available. The quality improved, varied by region only a cases validated clinicians. Regional variations mastectomy...
It is well documented that individuals struggle to understand cardiovascular disease (CVD) percentage risk scores, which led the development of heart age as a means communicating risk. Developed for clinical use, its application in raising public awareness health part self-directed digital test has not been considered previously.This study aimed who accesses England's (HAT) and effect on user perception, knowledge, understanding CVD risk; future behavior intentions; potential engagement with...
Objectives: To explore equity in the invitation to and uptake of NHS Health Check (NHSHC) along with variation risk factor profiles referrals follow-up interventions across sociodemographic groups England.Design: A cross-sectional observational studySetting: National primary care data extracted directly by Digital from 90% General Practices (GP) England. Participants: 9,164,975 individuals aged 40-74 years invited an NHSHC (2012-2017), defined using Read codes.Intervention: The NHSHC, a...
<h3>Background</h3> The JBS3 risk calculator offers a novel approach to cardiovascular communication by estimating “heart age”. A modified version of this tool was introduced online broaden access personalized assessment the general population and encourage participation in NHS Health Check programme. This study reports on its early uptake profiles those who used it. <h3>Methods</h3> estimates a”heart age”, through multivariable modelling which is referenced someone same age, gender...
annual age-adjusted breast cancer death rates for women in the United States remained remarkably constant, oscillating around 32 deaths per 100,000 over 60 years.During this long timeframe, surgical treatment of evolved from radical mastectomy with mandatory lymph node dissection to lumpectomy coupled radiation therapy.With new paradigm, was reserved tumor-invaded axillary nodes.Beginning 1970s, chemotherapy after surgery (adjuvant) and before (neoadjuvant) added treatment.The diminution...