A5103141824- Functional Brain Connectivity Studies
- Dementia and Cognitive Impairment Research
- Medical Imaging Techniques and Applications
- Alzheimer's disease research and treatments
- Advanced MRI Techniques and Applications
- Memory and Neural Mechanisms
- Advanced Neuroimaging Techniques and Applications
- Neural and Behavioral Psychology Studies
- Cerebrovascular and Carotid Artery Diseases
- Radiomics and Machine Learning in Medical Imaging
- Transcranial Magnetic Stimulation Studies
- Memory Processes and Influences
- Neurobiology of Language and Bilingualism
- MRI in cancer diagnosis
- Neurological Disease Mechanisms and Treatments
- Cannabis and Cannabinoid Research
- Radiopharmaceutical Chemistry and Applications
- Neuroscience and Neuropharmacology Research
- Cardiovascular Health and Disease Prevention
- Action Observation and Synchronization
- Face Recognition and Perception
- Acute Ischemic Stroke Management
- Vestibular and auditory disorders
- Hearing Impairment and Communication
- Hematological disorders and diagnostics
Moffitt Cancer Center
2025
University of Iowa
2015-2024
Alzheimer’s Disease Neuroimaging Initiative
2023-2024
University of Iowa Hospitals and Clinics
2006-2023
Cohort (United Kingdom)
2023
Imaging Center
2000-2021
Translational Therapeutics (United States)
2017
University of Nebraska Medical Center
2009
Technical University of Munich
2009
KU Leuven
2009
Patients suffering from schizophrenia display subtle cognitive abnormalities that may reflect a difficulty in rapidly coordinating the steps occur variety of mental activities. Working interactively with prefrontal cortex, cerebellum play role both motor and performance. This positron-emission tomography study suggests presence prefrontal-thalamic-cerebellar network is activated when normal subjects recall complex narrative material, but dysfunctional schizophrenic patients they perform same...
This study used positron emission tomography to examine two kinds of personal memory that are in psychiatric evaluation: focused episodic (recall past experience, employed "taking a history") and random (uncensored thinking about examined during analytic therapy using free association). For comparison, third task was tap impersonal represents general information the world ("semantic memory").Thirteen subjects were studied [15O]H2O method obtain quantitative measurements cerebral blood flow....
OBJECTIVE: To assist in the development of a model for psychopathology emotions, present study sought to identify neural circuits associated with evaluation visual stimuli emotional valence. METHOD: Seventeen healthy individuals were shown three sets emotionally laden pictures carrying pleasant, unpleasant, and neutral content. While subjects evaluated picture set valence, regional cerebral blood flow was measured use [15O] water positron emission tomography. Subjective ratings valence...
Both lesion and functional imaging studies have implicated sectors of high-order association cortices the left temporal lobe in retrieval words for objects belonging to varied conceptual categories. In particular, located pole been associated with naming unique persons from faces. Because this neuroanatomical-behavioral might be related either specificity task (retrieving a name at level) or possible preferential processing faces by anterior cortices, we performed PET experiment test...
Short-term and long-term retention of experimentally presented words were compared in a sample 33 healthy normal volunteers by the [15O]H2O method with positron emission tomography (PET). The design included three conditions. For condition, subjects thoroughly studied 18 1 week before PET study. short-term shown another set 60 sec imaging, instructions to remember them. baseline subtracted from two memory conditions, read third that they had not previously seen experiment. Similar regions...
Loss of the capacity to experience pleasure (anhedonia) is a core clinical feature schizophrenia. Although functional imaging techniques have been successful in identifying neural basis cognitive impairments schizophrenia, no attempts date made investigate systems underlying emotional disturbances.To study processing schizophrenia by exploring pattern brain responses olfactory stimuli patients and healthy volunteers.Positron emission tomographic with volunteers. Positron data were collected...
OBJECTIVE: This study sought to describe brain regions associated with the personality dimension of introversion/extraversion. METHOD: Measures cerebral blood flow (CBF) were obtained from 18 healthy subjects by means [15O]H2O positron emission tomography. Correlations regional CBF introversion/extraversion calculated, and a three-dimensional map those correlations was generated. RESULTS: Overall, introversion increased in frontal lobes anterior thalamus. Regions cingulate gyrus, temporal...
This study explored the neural circuitry used during recall of unstructured verbal material in schizophrenic patients and healthy volunteer subjects.The subjects were 13 volunteers 14 patients. All free medication, all right-handed. Two experimental cognitive conditions used: novel practiced word lists (two 15-item from Rey Auditory Verbal Learning Test). Both active tasks compared with an eyes-closed resting baseline condition. A nonparametric randomization test was to determine within-...
Schizophrenia is currently conceptualized as a disease of functional neural connectivity, leading to symptoms that affect aspects mental activity, including perception, attention, memory, and emotion. The substrates its emotional components have not been extensively studied with neuroimaging. Previous neuroimaging studies examined medicated patients schizophrenia. authors measured regional cerebral blood flow (rCBF) during performance task required unmedicated recognize the valence visual...
The cerebellum has traditionally been considered to be primarily dedicated motor functions. Its phylogenetic development and connectivity suggest, however, that it also may play a role in cognitive processes the human brain. In order examine potential for beings, positron emission tomography (PET) study was conducted during "pure thought experiment": subjects intentionally recalled specific past personal experience (consciously retrieved episodic memory). Since there no or sensory input...
Whether chronicity of illness produces progressive neural abnormality is an important question in current schizophrenia research. Positron emission tomography (PET) offers opportunity to visualize and measure blood flow vivo address this issue. The authors previously compared healthy volunteers with neuroleptic-naive patients experiencing their first episode reported that abnormalities flow, including lower prefrontal regions higher the thalamus cerebellum, are present at early stage...
Melanocortin 4 receptor (MC4R) signaling mediates diverse physiological functions, including energy balance, glucose homeostasis, and autonomic activity. Although the lateral hypothalamic area (LHA) is known to express MC4Rs receive input from leptin-responsive arcuate proopiomelanocortin neurons, functions of in LHA are incompletely understood. We report that MC4RLHA regulates tolerance sympathetic nerve Restoring expression specifically improves intolerance obese MC4R-null mice without...
This study was undertaken to identify brain structures associated with emotion in normal elderly subjects.Eight subjects aged 55-78 years were shown film clips intended provoke the emotions of happiness, fear, or disgust as well a neutral state. During emotional activation, regional cerebral blood flow measured use [15O]H2O positron emission tomography imaging, and subjective responses recorded. Data analyzed by subtracting values during condition from various activations.The stimuli...