A5083869764- Neonatal Respiratory Health Research
- Respiratory viral infections research
- Immune Response and Inflammation
- Respiratory Support and Mechanisms
- Viral Infections and Immunology Research
- Insect Resistance and Genetics
- Mosquito-borne diseases and control
- Malaria Research and Control
- IL-33, ST2, and ILC Pathways
- Asthma and respiratory diseases
- Advanced Image Processing Techniques
- Vector-Borne Animal Diseases
- Advanced Vision and Imaging
- Systemic Lupus Erythematosus Research
- Misinformation and Its Impacts
- Ethics in Clinical Research
- Genetically Modified Organisms Research
- NF-κB Signaling Pathways
- Pediatric health and respiratory diseases
- Social Media in Health Education
- Autoimmune and Inflammatory Disorders Research
- Lysosomal Storage Disorders Research
- Insect Pest Control Strategies
- Long-Term Effects of COVID-19
- Neuroinflammation and Neurodegeneration Mechanisms
Brigham and Women's Hospital
2018-2025
Boston Children's Hospital
2025
Boston Medical Center
2025
Dana-Farber Brigham Cancer Center
2024
Dana-Farber Cancer Institute
2024
Harvard University
2018-2023
University of Arizona
2011
Johns Hopkins University
2007
American Association For The Advancement of Science
2000
The resolution of infection is an active process with specific molecular and cellular mechanisms that temper inflammation enhance pathogen clearance. Here, the specialized pro-resolving mediator (SPM) Maresin 1 (MaR1) inhibited respiratory syncytial virus (RSV)-induced inflammation. inlerleukin-13 production from type 2 innate lymphoid cells (ILC) CD4 T helper was decreased by exogenous MaR1. In addition, MaR1 increased amphiregulin RSV viral transcripts to promote resolution. also promoted...
Specialized proresolving mediators (SPMs) decrease NF-κB activity to prevent excessive tissue damage and promote the resolution of acute inflammation. Mechanisms for regulation by SPMs remain be determined. In this study, after LPS challenge, 15-epi-lipoxin A4 (15-epi-LXA4), resolvin D1, D2, D3, 17-epi-resolvin D1 were produced in vivo murine lungs. LPS-activated human bronchial epithelial cells, select increased expression regulators A20 single Ig IL-1R-related molecule (SIGIRR). Of...
Importance Patients often visit the emergency department (ED) near end of life. Their common disposition is inpatient hospital admission, which can result in a delayed transition to hospice care and, ultimately, an death that may be misaligned with their goals care. Objective To assess association use novel multidisciplinary program rapidly identify and enroll eligible patients presenting ED Design, Setting, Participants This pre-post quality improvement study novel, multifaceted transitions...
Viral pneumonias are a major cause of morbidity and mortality, owing in part to dysregulated excessive lung inflammation, therapies modulate host responses viral injury urgently needed. Protectin conjugates tissue regeneration 1 (PCTR1) protectin D1 (PD1) specialized pro-resolving mediators (SPMs) whose roles pneumonia interest. In mouse model Respiratory Syncytial Virus (RSV) pneumonia, intranasal PCTR1 PD1 each decreased RSV genomic load when given after infection. Concurrent with enhanced...
Abstract NK cells provide immune surveillance and host protection against viruses tumors through their cytotoxic effector function. Cytoskeletal rearrangement is necessary for cell lytic granule trafficking synapse formation to trigger apoptosis of targeted cells. LIM kinase (LIMK) regulates F-actin remodeling by phosphorylating cofilin inhibit actin severing depolymerization. In this study, in human cells, the glucocorticoid dexamethasone downregulated LIMK expression, accumulation at...
Non-cytopathogenic pestivirus obtained from lambs with border disease, or without nervous signs, was inoculated into pregnant ewes at 57 to 65 days of gestation. Live born were clinically identical the which virus obtained, ie, either a hairy birth coat central system disturbance disturbance.
Determine the role of surfactant protein D (SPD) in sepsis.Murine vivo study.Research laboratory at an academic medical center.SPD knockout (SPD-/-) and wild-type (SPD+/+) mice.SPD-/- SPD+/+ mice were subjected to cecal ligation puncture (CLP). After CLP, Escherichia coli bacteremia was assessed both groups. Cecal contents from groups cultured assess for colonization by E. coli. To control parental effects on microbiome, SPD-/- bred heterozygous parents, levels their ceca measured. Gut...
The speed and scale of new information during the COVID-19 pandemic required a approach toward developing best practices evidence-based clinical guidance. To address this need, we produced COVIDProtocols.org, collaborative, evidence-based, digital platform for development dissemination guidelines that has been used by over 500,000 people from 196 countries. We use Collaborative Writing Application (CWA) to facilitate an expedited expert review process web deploys content directly CWA...
Abstract Asthma tends to “run in families” is a concept supported by several research studies of asthma genetics, but this only explains relatively small fraction inheritance. We are now standing paradigm on its head asking the opposite question: Can protection be passed from one generation next? Epidemiological and experimental have determined that early postnatal period offers critical window for establishment lung protection. Maternal milk represents potentially important...
A 32-year-old woman presented with worsening epigastric pain. She also reported chills, night sweats, a nonproductive cough, intermittent dyspnea and wheezing, an unintentional 20-lb weight loss.