A5088174786- Inflammatory Bowel Disease
- Gastrointestinal Bleeding Diagnosis and Treatment
- Gastrointestinal disorders and treatments
- Gastrointestinal Tumor Research and Treatment
- Microscopic Colitis
- Liver Diseases and Immunity
- Diagnosis and treatment of tuberculosis
- Pregnancy and Medication Impact
- Helicobacter pylori-related gastroenterology studies
- Liver Disease Diagnosis and Treatment
- Neurofibromatosis and Schwannoma Cases
- Reproductive System and Pregnancy
- Cardiovascular Issues in Pregnancy
- Gallbladder and Bile Duct Disorders
- Cytomegalovirus and herpesvirus research
- Pregnancy and preeclampsia studies
- Syphilis Diagnosis and Treatment
- Diverticular Disease and Complications
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Systemic Lupus Erythematosus Research
- Pharmacological Effects of Natural Compounds
- Galectins and Cancer Biology
- Esophageal and GI Pathology
- Gastroesophageal reflux and treatments
Tokyo Women's Medical University
2018-2025
Tokyo Women's Medical University Hospital
2020
Artificial intelligence (AI)-assisted colonoscopy systems with contact microscopy capabilities have been reported previously; however, no studies regarding the clinical use of a commercially available system in patients ulcerative colitis (UC) reported. In this study, diagnostic performance an AI-assisted ultra-magnifying for histological healing was compared that conventional light non-magnifying endoscopic evaluation UC.
Background: Small bowel (SB) lesions in quiescent Crohn’s disease (CD) are sometimes not identified by clinical activity or existing markers. We investigated the usefulness of a novel biomarker, leucine-rich α2-glycoprotein (LRG), for screening presence SB ulcerative detected small-bowel capsule endoscopy (SBCE). Methods: examined patients with Disease Activity Index (CDAI) value < 150 and C-reactive protein (CRP) 0.5 mg/dL colonic CD. The (≥0.5 cm) was grouped SBCE results, we then compared...
Tofacitinib (TOF), a Janus kinase inhibitor, has emerged as an innovative treatment option for patients with moderate-to-severe ulcerative colitis (UC). However, the clinical course of who achieve induction and maintain remission followed by TOF tapering or withdrawal is unclear. We investigated efficacy after in real-world practice. Thirty-two treated 20 mg/day UC relapse between October 2018 August 2023 were included this single-center, retrospective observational study. Disease activity...
Background/Aims: Small bowel capsule endoscopy (SBCE) is an evaluation method for small (SB) lesions in Crohn’s disease (CD). However, the relationship between SBCE findings and serological biomarker leucine-rich alpha-2 glycoprotein (LRG) remains unclear. We aimed to establish appropriate cutoff values of LRG predict presence SB CD through SBCE.Methods: Patients with who had undergone measurements 1 month before after were included. The ulcers ≥0.5 cm other inflammatory noted determined...
Abstract Background and study aims The aim of this was tp compare the diagnostic efficiency PillCam SB3 capsule endoscopy (CE) system with older system, SB2, taking into consideration experience image reader. Patients methods Small intestinal CE conducted on 64 patients around May 2014 when introduced in our hospital. Data obtained from 20 (SB2: 10 SB3: 10) based transit time were assessed by junior (experience: images), intermediate (> 50), expert readers 600). Results Reading down to...
The Lewis Score (LS) and Capsule Endoscopy Crohn's Disease Activity Index (CECDAI) are the two currently used small bowel capsule endoscopy (SBCE) scoring systems for disease (CD). present study describes a new system evaluation of CD, especially mucosal inflammation.In this cross-sectional study, 108 CD patients underwent 196 SBCEs. lesions were scored using our in (CDACE). CDACE is sum scores location inflammation, range stenosis, with value ranging from 0 to 1643. We analyzed relation...
Introduction: Confirmation of intestinal patency using the capsule (PC) in 30–33 h may result a complex testing schedule. The aim this study was to perform and evaluate 24-h PC procedure for potential use as simple easy-to-apply assessment method. Subject Methods: included 342 patients who were assessed 24 after ingesting patency. elimination rate distribution time evaluated. Results: Assessment conducted 308 (90%) patients. Self-confirmed within possible 104 (30.4%) considered have been...
Objectives. The clinical/colonoscopic features of ulcerative colitis (UC) associated with primary sclerosing cholangitis (PSC), the prognostic impact UC, and utility UC screening in PSC patients are unknown. We characterized assessed UC’s on prognosis importance colonoscopic patients. Methods. retrospectively analyzed cases 77 treated for at a single center (April 2000–July 2019). reviewed profiles concurrent compared clinical profiles, survival, causes death between with/without ( <math...
Objective Anti-tumor necrosis factor (TNF)-α antibody-based regimens are effective in Behçet's disease (BD) with intestinal lesions. We therefore evaluated the efficacy of medium- to long-term anti-TNF-α maintenance therapy BD and non-intestinal
Coronavirus disease 2019 (COVID-19), caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is now a pandemic. Although several treatment guidelines have been proposed for patients who both inflammatory bowel and COVID-19, immunosuppressive therapy essentially not recommended, the options are limited. Even in COVID-19 pandemic, adjuvant adsorptive granulocyte monocyte apheresis may safely bring ulcerative colitis (UC) into remission removing activated myeloid...
Background and Aim: Tacrolimus is highly effective in intractable ulcerative colitis, but maintenance may be problematic. This study examined 52-week adverse events.
 Methods: retrospective of patients who used tacrolimus from April 2009 to December 2021 (N = 136) remission induction rates background factors the (n 108) non-remission groups 28); maintenance; drug-specific (azathioprine [n 58] vs 12] biological product [Bio, n 8]); Results: The mean observation period was 1230175 days....
The patient was a woman in her 40s who diagnosed with Crohn's disease (CD) of the large and small intestines 1996. In 2005, she referred to our hospital for treatment. We treated 17 years corticosteroids, biologics, immunosuppressive agents, 5-aminosalicylic acid, nutrition care. However, Disease Activity Index remained between 200 250, indicating refractory CD. During medical treatment, also underwent 3 operations. One year ago, became pregnant through vitro fertilization. Even after...
Small bowel (SB) capsule endoscopy (SBCE) is a sensitive modality for screening the entire SB of patients with Crohn's disease (CD); however, prognostic impact results unclear. We evaluated ability SBCE score to predict therapeutic intervention CD and lesions without clinical symptoms as well negative C-reactive protein (CRP) levels.
Intestinal motility may be different in obese and nonobese patients, but this has not been determined. Here, we sought to evaluate the effect of obesity on small bowel capsule endoscopy (SBCE). Patients Methods. We retrospectively analyzed cases 340 patients who underwent SBCE for intestinal disease (excluding unobservable total bowel, stenosis, resection) at our hospital during period January 2014 December 2020 extract patient background factors transit times according presence/absence...
We treated a 39-year-old Japanese man who was admitted for an abdominal mass. He had neurofibroma-like skin lesions since childhood. Computed tomography and endoscopic ultrasound results were consistent with tumor in the small intestine. Although undetectable by single-balloon endoscopy, patient’s background imaging led us to suspect gastrointestinal stromal (GIST). also met diagnostic criteria neurofibroma type 1 (NF1). performed surgical removal of tumor, biopsy definitive diagnosis GIST....
Abstract A 60‐year‐old man presented with a suspected small intestinal tumor on positron‐emission tomography‐computed tomography. Small bowel capsule endoscopy (SBCE) was planned for close examination of the intestine. To avoid retention SBCE due to strictures, patency (PC) first used evaluate patency. However, PC discharge not visually confirmed during 24‐h period. No obvious observed plain abdominal radiography performed in standing position. The patient underwent SBCE, assuming that had...
Abstract Background and Aims Primary sclerosing cholangitis has a poor prognosis can be accompanied by ulcerative colitis. Infection control is essential, so immunosuppressive drugs should ideally preferably. Granulocyte monocyte adsorptive apheresis does not suppress the immune system used to treat Therefore, this study investigated efficacy safety of granulocyte in patients with primary Methods We retrospectively evaluated data from colitis who visited our hospital April 2000 December 2022...
Background: Ulcerative Colitis (UC) has a marked influence on the lifestyle of patients, and its effects pregnancy childbirth can especially become problem for women in their child-bearing years. Various studies have suggested that it is desirable pregnant with UC to give birth while remaining state remission. The present study evaluated attending our hospital who became during remission, order examine factors contributed recurrence pregnancy. Methods: We investigated 40 patients remission...
A 43-year-old man presented to our hospital with the chief complaint of melena. An ulcerating lesion suggestive inflammatory bowel disease was detected in rectum by colonoscopy. Subsequently, epigastric pain occurred and upper gastrointestinal endoscopy performed, revealing multiple irregular ulcers throughout stomach. Immunohistochemical examination a gastric mucosa biopsy specimen Treponema pallidum. In addition, serological test for syphilis antibody positive pallidum also found rectal...