A5071788426- Aortic aneurysm repair treatments
- Peripheral Artery Disease Management
- Coronary Interventions and Diagnostics
- Cerebrovascular and Carotid Artery Diseases
- Vascular Procedures and Complications
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiovascular Health and Disease Prevention
- Aortic Disease and Treatment Approaches
- Elasticity and Material Modeling
- Infectious Aortic and Vascular Conditions
- Renal and Vascular Pathologies
- Connective tissue disorders research
- Venous Thromboembolism Diagnosis and Management
- Trauma and Emergency Care Studies
- Orthopaedic implants and arthroplasty
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Intracranial Aneurysms: Treatment and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiovascular and exercise physiology
- Hemodynamic Monitoring and Therapy
- Cardiac Valve Diseases and Treatments
- Parathyroid Disorders and Treatments
- Central Venous Catheters and Hemodialysis
- Muscle metabolism and nutrition
- Cardiac Structural Anomalies and Repair
University of Nebraska Medical Center
2016-2025
University of Nebraska at Omaha
2013-2024
Denver Health Medical Center
2019-2021
University of Colorado Denver
2019-2021
University of Colorado Anschutz Medical Campus
2020-2021
Denver Public Health
2020-2021
American College of Surgeons
2020
St. Luke's Hospital
2019
Google (United States)
2018
University of Maryland, Baltimore
2017
Abdominal aortic aneurysm (AAA) is one of a number diseases associated with prominent inflammatory cell infiltrate and local destruction structural matrix macromolecules. This chronic predominately composed macrophages T lymphocytes. Activated produce variety cytokines, including TNF-alpha. Elevated levels TNF-alpha were observed in patients AAA, suggesting that may play role the pathogenic mechanisms AAA. In present study, we investigated AAA formation. By studying murine model, found both...
The objective of this study was to assess the impact preoperative anemia (hematocrit <39%) on postoperative 30-day mortality and adverse cardiac events in patients 65 years or older undergoing elective vascular procedures.Preoperative is associated with outcomes after surgery, but its association open endovascular procedures not well established. Elderly have a decreased tolerance are at high risk for complications procedures.Patients (N = 31,857) were identified from American College...
During arterial aneurysm formation, levels of the membrane-anchored matrix metalloproteinase, MT1-MMP, are elevated dramatically. Although MT1-MMP is expressed predominately by infiltrating macrophages, roles played proteinase in abdominal aortic (AAA) formation vivo remain undefined. Using a newly developed chimeric mouse model AAA, we now demonstrate that macrophage-derived plays dominant role disease progression. In wild-type mice transplanted with MT1-MMP-null marrow, induced application...
Arterial calcification and stiffening increase the risk of reconstruction failure, amputation, mortality in patients with peripheral arterial disease, but underlying mechanisms prevalence are unclear.Fresh human femoropopliteal arteries were obtained from n=431 tissue donors aged 13 to 82 years (mean age, 53±16 years) recording situ longitudinal prestretch. diameter, wall thickness, opening angles measured optically, stiffness was assessed using planar biaxial extension constitutive...
Background: Poor durability of femoropopliteal artery (FPA) stenting is multifactorial, and severe FPA deformations occurring with limb flexion are likely involved. Different stent designs result in dissimilar stent–artery interactions, but the degree these effects insufficiently understood. Objectives: To determine how different affect flexion-induced deformations. Methods: Retrievable markers were deployed into n = 28 FPAs lightly embalmed human cadavers. Bodies perfused CT images acquired...
High failure rates of femoropopliteal artery (FPA) interventions are often attributed to severe mechanical deformations that occur with limb movement. Torsion the FPA likely plays a significant role, but is poorly characterized and associated intramural stresses currently unknown. torsion in walking, sitting gardening postures was n = 28 situ FPAs using intra-arterial markers. Principal strains were quantified superficial femoral (SFA), adductor hiatus segment (AH) popliteal (PA) analytical...
The recessive disease arterial calcification due to deficiency of CD73 (ACDC) presents with extensive nonatherosclerotic medial layer in lower extremity arteries. Lack induces a concomitant increase TNAP (tissue nonspecific alkaline phosphatase; ALPL), key enzyme ectopic mineralization. Our aim was investigate how loss activity leads increased ALPL expression and CD73-deficient patients assess whether this mechanism may apply peripheral artery calcification. Approach Results: We previously...
ObjectiveFor peripheral arterial disease, infrainguinal bypass grafting (BPG) carries a higher perioperative risk compared with endovascular procedures. The choice between the open and therapies is to an extent dependent on expected periprocedural associated each. Tools for estimating in patients undergoing BPG have not been reported literature. objective of this study was develop validate calculator estimate mortality ≤30 days elective BPG.MethodsWe identified 9556 (63.9% men) who underwent...