A5064580065- Cardiac Valve Diseases and Treatments
- Connective tissue disorders research
- Advanced Neuroimaging Techniques and Applications
- Schizophrenia research and treatment
- Dermatological and Skeletal Disorders
- Aortic Disease and Treatment Approaches
- Telomeres, Telomerase, and Senescence
- Electrospun Nanofibers in Biomedical Applications
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Functional Brain Connectivity Studies
- Neonatal Respiratory Health Research
- Congenital Diaphragmatic Hernia Studies
- Fetal and Pediatric Neurological Disorders
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Alkaline Phosphatase Research Studies
- Water-Energy-Food Nexus Studies
- Blood Coagulation and Thrombosis Mechanisms
- Cardiovascular and Diving-Related Complications
- Genomic variations and chromosomal abnormalities
- Cardiovascular Disease and Adiposity
- Cystic Fibrosis Research Advances
- Congenital Heart Disease Studies
- Medical Imaging and Pathology Studies
- Genetic Associations and Epidemiology
- Advanced MRI Techniques and Applications
University of Pittsburgh
2019-2025
University of Pennsylvania
2024-2025
Minnesota State University Moorhead
2020-2021
Royal Edinburgh Hospital
2005-2010
University of Edinburgh
2005-2008
BACKGROUND: Calcific aortic valve disease is the pathological remodeling of leaflets. The initial steps in leaflet osteogenic reprogramming are not fully understood. As TERT (telomerase reverse transcriptase) overexpression primes mesenchymal stem cells to differentiate into osteoblasts, we investigated whether contributes interstitial cells. METHODS: Human control and calcific leaflets patient-specific human were used vivo vitro calcification assays. Loss function experiments isolated from...
Abstract Bipolar disorder and schizophrenia are highly heritable conditions that associated with structural brain abnormalities. Although abnormalities found in the well relatives of people schizophrenia, extent to which genetic liability relates structure either is still unclear. This study sought ascertain effects bipolar on white grey matter volume patients these diagnoses their relatives. Seventy‐one 72 unaffected were recruited for study. Patients included those from families affected...
The recessive disease arterial calcification due to deficiency of CD73 (ACDC) presents with extensive nonatherosclerotic medial layer in lower extremity arteries. Lack induces a concomitant increase TNAP (tissue nonspecific alkaline phosphatase; ALPL), key enzyme ectopic mineralization. Our aim was investigate how loss activity leads increased ALPL expression and CD73-deficient patients assess whether this mechanism may apply peripheral artery calcification. Approach Results: We previously...
Peripheral artery disease (PAD) is the narrowing of arteries that carry blood to lower extremities. PAD has been traditionally associated with atherosclerosis. However, recent studies have found thrombotic events triggered by medial arterial calcification (MAC) primary cause chronic limb ischemia below knee. MAC localized around elastic fibers surrounding smooth muscle cells (SMCs) in arteries. Matrix GLA protein (MGP) binds circulating calcium and prevents hydroxyapatite mineral deposition,...
Abstract Two male, entire Belgian Malinois dogs, ages 4 and 7 years, presented with firm, intramuscular masses in the medial left thigh. The 7‐year‐old dog a Grade I/V pelvic limb lameness. Fine‐needle aspiration of each revealed mesenchymal cells few mixed inflammatory cells, which were concerning for underlying neoplasia. Computed tomography findings included hypoattenuating mass lesions within gracilis muscles on pre‐contrast images strong peripheral contrast enhancement. Histopathology...
ABSTRACT Peripheral artery disease (PAD) is the narrowing of arteries that carry blood to lower extremities. PAD has been traditionally associated with atherosclerosis. However, recent studies have found medial arterial calcification (MAC) primary cause chronic limb ischemia below knee. MAC involves elastin fibers surrounding smooth muscle cells (SMCs) in arteries. Matrix GLA Protein (MGP) binds circulating calcium and inhibits vascular calcification. Mgp -/- mice develop severe die within 8...
Case series summary Cystic bronchiectasis was diagnosed in three cats with known histories of chronic coughing using CT and histopathology. the lungs revealed large space-occupying lesions that compressed displaced unaffected pulmonary parenchyma vessels. The masses were soft tissue attenuating two cases gas-cavitated areas dependent fluid one case. All found to have mineral material other dilatated airways. Generalized bronchial wall thickening also present indicative lower airway disease....
Arterial calcification due to deficiency of CD73 (ACDC) is a rare genetic disease caused by loss-of-function mutation in the
ABSTRACT Background Calcific aortic valve disease (CAVD) is the pathological remodeling of leaflets. The initial steps in osteogenic reprogramming leaflet are not fully understood. Studies have shown that TERT overexpression primes mesenchymal stem cells to differentiate into osteoblasts, and we investigated whether contributes interstitial (VICs). Methods Human control CAVD leaflets patient-specific hVICs were used vivo vitro calcification assays. Loss function experiments isolated from...
Calcific aortic valve disease (CAVD) is present in nearly a third of the elderly population. Thickening, stiffening, and calcification causes stenosis contributes to heart failure stroke. Disease pathogenesis multifactorial, stresses such as inflammation, extracellular matrix remodeling, turbulent flow, mechanical stress strain contribute osteogenic differentiation endothelial interstitial cells. However, precise initiating factors that drive transition healthy cell into calcifying are not...
Introduction: Calcific aortic valve disease (CAVD) is a disorder characterized by the slow, but progressive thickening of leaflet that develops into severe calcification. The only current therapy replacement. Telomerase an enzymatic complex best known for its telomere-extending activities on ends chromosomes yet, catalytic subunit (TERT) has been implicated in multiple non-canonical transcriptional and epigenetic activities, including priming mesenchymal stem cells (MSCs) to differentiate...
Intro: Telomerase (TERT) is an enzyme best known for its telomere-extending activities on the ends of chromosomes, however, less are non-canonical, transcriptional and epigenetic actitivies TERT. We sought to assess if TERT, through non-canonical activities, contributes progression calcific aortic valve disease (CAVD). It has been established that overexpression TERT in mesenchymal stem cells primes these differentiate into osteoblasts. Other studies have identified roles inducing...
ACDC (arterial calcification due to deficiency of CD73) is an autosomal recessive genetic disease that leads peripheral artery medial-layer vascular calcification. Loss-of-function mutations in NT5E , which encodes the 5’-ectoncleotidase CD73, inhibit ability CD73 breakdown extracellular AMP adenosine and inorganic phosphate. Our overarching goal define how a lack its downstream signaling contribute phenotypes. We previously found exogenous or treatment with rapamycin significantly reduced...
Calcific aortic valve disease (CAVD) is the leading heart disorder in US. It characterized by an active accumulation of calcium nodules on leaflets which lead to stiffening and remodeling causing dysfunction, cardiac failure increased stroke risk. Inflammation mechanical stresses contribute CAVD pathogenesis. However, mechanisms driving fibrocalcific are currently ill-defined. Multiple studies have revealed that catalytic subunit telomerase reverse transcriptase (TERT) can induce gene...
Calcific aortic valve disease (CAVD) is present in nearly a third of the elderly population. Thickening, stiffening, and calcification causes stenosis contributes to heart failure stroke. Disease pathogenesis multifactorial, stresses such as inflammation, extracellular matrix remodeling, turbulent flow, mechanical stress strain contribute osteogenic differentiation endothelial interstitial cells. However, precise initiating factors that drive transition healthy cell into calcifying are not...