A5040920721- Dyeing and Modifying Textile Fibers
- Intracerebral and Subarachnoid Hemorrhage Research
- Wound Healing and Treatments
- Silk-based biomaterials and applications
- Skin Protection and Aging
- Advanced Drug Delivery Systems
- Drug Solubulity and Delivery Systems
- Nanoparticle-Based Drug Delivery
- Dermatologic Treatments and Research
- Electrospun Nanofibers in Biomedical Applications
- Monoclonal and Polyclonal Antibodies Research
- Nerve injury and regeneration
- Electrohydrodynamics and Fluid Dynamics
- Acute Ischemic Stroke Management
- Neuroscience and Neural Engineering
- RNA Interference and Gene Delivery
- SARS-CoV-2 and COVID-19 Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Graphene and Nanomaterials Applications
- CAR-T cell therapy research
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurosurgical Procedures and Complications
- Advanced Sensor and Energy Harvesting Materials
- Enzyme Production and Characterization
- Lipid Membrane Structure and Behavior
Chongqing University
2015-2024
Nanchang Hangkong University
2021-2023
Chongqing Cancer Hospital
2023
Massachusetts Institute of Technology
2020-2022
Bioengineering Center
2012-2019
In recent years, favorable enhanced wound-healing properties and excellent biocompatibility of keratin derived from human hair have attracted considerable attention. Recombinant proteins can be produced by recombinant DNA technology higher purity than extracted keratin. However, the remain unclear. Herein, two trichocyte keratins including type I 37 II 81 were expressed using a bacterial expression system, nanoparticles (RKNPs) prepared via an ultrasonic dispersion method. The molecular...
Nanotechnology-based drug delivery systems have been widely used for oral and systemic dosage forms depending on the mucoadhesive interaction, keratin has applied biomedical applications delivery. However, few reports focused keratin-based system their mechanisms of mucoadhesion. Thus, mucoadhesion controlled kerateine (reduced keratin, KTN)/keratose (oxidized KOS) composite nanoparticles were prepared via adjusting proportion KTN KOS to achieve gastric release based different abilities...
A physically transient non-volatile memory device made of keratin exhibits great resistive switching performance.
H uman s erum a lbumin (HSA) is highly water-soluble protein with 67% alpha-helix content and three distinct domains (I, II, III). HSA offers great promise in drug delivery enhanced permeability retention effect. But it hindered by denaturation during entrapment or conjugation that result cellular transport pathways reduction of biological activities. Here we report using design approach named r everse- QTY (rQTY) code to convert specific hydrophilic alpha-helices hydrophobic alpha-helices....
Cytokine release syndrome (CRS), or 'cytokine storm', is the leading side effect during chimeric antigen receptor (CAR)-T therapy that potentially life-threatening. It also plays a critical role in viral infections such as Coronavirus Disease 2019 (COVID-19). Therefore, efficient removal of excessive cytokines essential for treatment. We previously reported novel protein modification tool called QTY code, through which hydrophobic amino acids Leu, Ile, Val and Phe are replaced by Gln (Q),...
Abstract Keratins are considered ideal candidates as hemostatic agents, but the development lags far behind their potentials due to poorly understood mechanism and structure–function relations, owing composition complexity in protein extracts. Here, it is shown that by using a recombinant synthesis approach, individual types of keratins can be expressed used for investigation further high‐performance keratin agent design. In comparative evaluation full‐length, rod‐domain, helical segment...
Abstract Shifting microglia/macrophages to M2 anti‐inflammatory phenotype is considered a pivotal therapeutic target for spinal cord injury (SCI). Keratin extracted from human hair exhibits properties. However, the differences among 17 types of keratins and their mechanisms anti‐inflammation remain poorly understood. In this study, activity using recombinant synthesis approach explored. Distinct activities microglia/macrophage modulation are found through qRT‐PCR analysis, keratin 33A...