A5062749798- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Sexual Differentiation and Disorders
- Urological Disorders and Treatments
- Reproductive Biology and Fertility
- Sperm and Testicular Function
- Renal and related cancers
Université Côte d'Azur
2022-2025
Inserm
2022-2025
Institut de Biologie Valrose
2022-2024
Centre National de la Recherche Scientifique
2022-2023
Gonadal sex determination represents a unique model for studying cell fate decisions. However, complete understanding of the different lineages forming developing testis and ovary remains elusive. Here, we investigated origin, specification, subsequent sex-specific differentiation previously uncharacterized population supporting-like cells (SLCs) in mouse gonads. The SLC lineage is closely related to coelomic epithelium specified as early E10.5, making it first somatic be bipotential gonad....
Sex determination in mammals depends on the differentiation of supporting lineage gonads into Sertoli or pregranulosa cells that govern testis and ovary development, respectively. Although Y-linked testis-determining gene Sry has been identified, ovarian-determining factor remains unknown. In this study, we identified -KTS, a major, alternatively spliced isoform Wilms tumor suppressor WT1, as key determinant female sex determination. Loss -KTS variants blocked gonadal mice, whereas increased...
Male genital development in XY mammalian fetuses is triggered by the action of hormones, including testosterone, secreted developing testes. Defects this process are a cause for Differences Sex Development (DSD), one most common congenital abnormalities humans. Fetal Leydig Cells (FLC) play central role synthesis masculinizing hormones Yet, genetic cascade controlling their differentiation poorly understood. Here we investigate orphan nuclear receptor NR2F2 (COUP-TFII) FLC development. We...
Male genital development in XY mammalian fetuses is triggered by the action of hormones, including testosterone, secreted developing testes. Defects this process are a cause for Differences Sex Development (DSD), one most common congenital abnormalities humans. Fetal Leydig Cells (FLC) play central role synthesis masculinizing hormones Yet, genetic cascade controlling their differentiation poorly understood. Here we investigate orphan nuclear receptor NR2F2 (COUP-TFII) FLC development. We...
Abstract Male genital development in XY mammalian fetuses is triggered by the action of hormones, including testosterone, secreted developing testes. Defects this process are a cause for Differences Sex Development (DSD), one most common congenital abnormalities humans. Fetal Leydig Cells (FLC) play central role synthesis masculinizing hormones Yet, genetic cascade controlling their differentiation poorly understood. Here we investigate orphan nuclear receptor NR2F2 (COUP-TFII) FLC...