A5086172722- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Sexual Differentiation and Disorders
- Reproductive Biology and Fertility
- Physiological and biochemical adaptations
- Animal Genetics and Reproduction
- Nematode management and characterization studies
- Renal and related cancers
- Essential Oils and Antimicrobial Activity
- Cancer therapeutics and mechanisms
- Marine Biology and Ecology Research
- Enzyme function and inhibition
- Hemoglobin structure and function
- Phytochemistry and Biological Activities
- Plant and animal studies
- Wnt/β-catenin signaling in development and cancer
- DNA and Nucleic Acid Chemistry
- Tardigrade Biology and Ecology
- PI3K/AKT/mTOR signaling in cancer
- Biochemical effects in animals
- Heme Oxygenase-1 and Carbon Monoxide
- Insect Utilization and Effects
- Sesquiterpenes and Asteraceae Studies
- Sperm and Testicular Function
- Nutrition, Genetics, and Disease
- Cell death mechanisms and regulation
Université Côte d'Azur
2019-2024
Inserm
2007-2024
Centre National de la Recherche Scientifique
2000-2024
Institut de Biologie Valrose
2020-2024
Université de Corse Pascal Paoli
2009-2020
Station Biologique de Roscoff
2000-2002
Adaptation et Diversité en Milieu Marin
2002
Sorbonne Université
2001
Sex determination in mammals depends on the differentiation of supporting lineage gonads into Sertoli or pregranulosa cells that govern testis and ovary development, respectively. Although Y-linked testis-determining gene Sry has been identified, ovarian-determining factor remains unknown. In this study, we identified -KTS, a major, alternatively spliced isoform Wilms tumor suppressor WT1, as key determinant female sex determination. Loss -KTS variants blocked gonadal mice, whereas increased...
Abstract R-spondin2 (RSPO2) is a member of the R-spondin family, which are secreted activators WNT/β-catenin (CTNNB1) signaling pathway. In mouse postnatal ovary, WNT/CTNNB1 active in oocyte and neighboring supporting cells, granulosa cells. Although role Rspo2 has been previously studied using vitro experiments, results conflicting vivo ovarian function remains unclear. present study, we found that RSPO2/Rspo2 expression restricted to developing follicles both human ovaries from beginning...
Expression of heat shock proteins (hsp) is a homeostatic mechanism induced in both prokaryotic and eukaryotic cells response to metabolic environmental insults. A growing body evidence suggests that mammals, the hsp integrated with physiological responses through neuroendocrine signaling. In present study, we have examined effect noradrenaline (NA) on hsp70 mollusc immune cells. Oyster abalone hemocytes transfected gene construct containing gastropod promoter linked luciferase reporter-gene...
In mammals, testicular differentiation is initiated by transcription factors SRY and SOX9 in XY gonads, ovarian involves R-spondin1 (RSPO1) mediated activation of WNT/β-catenin signaling XX gonads. Accordingly, the absence RSPO1/Rspo1 humans mice leads to female-to-male sex reversal a manner that does not requireSry or Sox9 mice. Here we show an alternate testis-differentiating factor exists this Sox8. Specifically, genetic ablation Sox8 prevents ovarian-to-testicular reprogramming observed...
The symbiotic tubeworm Riftia pachyptila needs to fuel its chemoautotrophic bacteria with inorganic carbon. CO(2) is transported from the surrounding water bacteriocytes located in trophosome, through branchial plume and body fluids. Previous studies have demonstrated implication of carbonic anhydrase (CA) proton pumps (ATPases) at various steps transport. present study describes expression pattern cytosolic CA using an RNA probe histochemical immunocytochemical localization trophosome...
Alvinella pompejana is a tubicolous polychaete that dwells in the hottest part of hydrothermal vent ecosystem highly variable mixture (350 degrees C, anoxic, CO(2)- and sulfide-rich) deep-sea (2 mildly hypoxic) waters. This species has developed distinct-and specifically respiratory-adaptations to this challenging environment. An internal gas exchange system recently been described, along with report an intracellular coelomic hemoglobin, addition previously known extracellular vascular...
Abstract The symbiotic hydrothermal vent tubeworm Riftia pachyptila needs to supply its internal bacterial symbionts with carbon dioxide, their inorganic source. Our aim in this study was characterize the carbonic anhydrase (CA) involved CO 2 transport and conversion at various steps plume tissue, trophosome. A complete 1209 kb cDNA has been sequenced from trophosome identified as a putative α‐CA based on BLAST analysis similarities of total deduced amino‐acid sequence those GenBank...
ABSTRACT The distribution of nitrogen metabolism end-products and the associated enzyme activities, free amino acids purine base catabolites were investigated in all body compartments (circulating fluids tissues) hydrothermal vent tubeworm Riftia pachyptila to acquire a general overview this symbiotic organism. There striking differences between symbiont-containing trophosome tissue other host tissues. High concentrations ammonia, creatinine and, particular, urate found tissues, but they...
Caspase‐2 exists as two main isoforms: the caspase‐2L long isoform, which is pro‐apoptotic, and caspase‐2S short may be anti‐apoptotic. Topoisomerase inhibitors drive inclusion of exon 9, specific for Casp‐2S mRNA, lower mRNA protein. With cell lines engineered to express various PKC isoforms, we demonstrate that zeta, but not PKCalpha, positively regulates assembly triggered by topoisomerase inhibitors. In addition, 9 lowered in mitosis increased G1/S phase. Hence, control caspase‐2 depends...
The objective of this study was to characterize Elionurus hensii in terms the chemical composition its essential oil and volatile fractions, total phenolic flavonoid contents solvent extracts antioxidative activity. Analysis E. samples from Congo carried out using Gas Chromatography (GC) Chromatography-Mass Spectrometry (MS). aerial parts consisted predominantly oxygenated monoterpene compounds, which main components were menthane alcohol stereoisomers, whereas root characterized by a high...
Abstract In mammals, testicular differentiation is initiated by transcription factors SRY and SOX9 in XY gonads, ovarian involves R-spondin1 (RSPO1) mediated activation of WNT/β-catenin signaling XX gonads. Accordingly, the absence RSPO1/Rspo1 humans mice leads to female-to-male sex reversal a manner that does not require Sry or Sox9 mice. Here we show an alternate testis-differentiating factor exists this Sox8 . Specifically, genetic ablation prevents ovarian-to-testicular reprogramming...