A5039854079- Thyroid Disorders and Treatments
- Thyroid Cancer Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Head and Neck Anomalies
- Monoclonal and Polyclonal Antibodies Research
- Ion channel regulation and function
- Thyroid and Parathyroid Surgery
- Growth Hormone and Insulin-like Growth Factors
- Vitamin D Research Studies
- Ophthalmology and Eye Disorders
- Liver Disease Diagnosis and Treatment
- Estrogen and related hormone effects
- Cancer Risks and Factors
- Cancer Diagnosis and Treatment
- Neuroscience of respiration and sleep
- Blood groups and transfusion
- Parathyroid Disorders and Treatments
- Ovarian function and disorders
- Adrenal Hormones and Disorders
- Metabolism, Diabetes, and Cancer
- Reproductive Biology and Fertility
- Sexual Differentiation and Disorders
- Helicobacter pylori-related gastroenterology studies
- Animal Genetics and Reproduction
- Nuclear Structure and Function
Azienda Ospedaliera Universitaria Pisana
2014-2024
University of Pisa
2009-2022
World Health Organization - Pakistan
2013
Ospedale Cisanello
2006
Massachusetts General Hospital
1999
Dartmouth College
1992
The clinical course of 306 Graves' patients treated with methimazole (MMI) was reviewed the aim establishing criteria able to predict remission hyperthyroidism after medical treatment. One hundred and ninetyfour (149 females, 45 males) (63.4%) had relapse antithyroid drug (ATD) withdrawal. Relapse more frequent during first months follow-up, but still it observed 3 years MMI rate dependent on age patient, size goiter, level TSH-receptor antibody (TRAb) at diagnosis, being in 40 47 (85%) high...
Higher TSH values, even within normal ranges, have been associated with a greater risk of thyroid malignancy. The relationship between and papillary cancer (PTC) has analyzed in 10 178 patients submitted to fine needle aspiration nodules cytology PTC (n=497) or benign nodular disease (BTND, n=9681). In 942 patients, surgery (521 from BTND 421 PTC), the histological diagnosis confirmed an elevated specificity (99.6%) sensitivity (98.1%) cytology. levels were significantly higher than both...
TSH is the main factor involved in control of proliferation thyrocytes. Recently, a strong relationship between serum and risk thyroid malignancy has been reported.The aim was to review published papers about frequency differentiated cancer.PubMed used identify studies focused on cancer.In patients with nodular disease, increases TSH, even within normal ranges, higher values are associated more advanced stage cancer. The likelihood papillary carcinoma reduced when lower, as autonomy,...
The possible association between Hashimoto's thyroiditis (HT) and papillary thyroid carcinoma (PTC) is a still debated issue. We analyzed the frequency of PTC, TSH levels autoantibodies (TAb) in 13 738 patients (9824 untreated 3914 under l -thyroxine, -T 4 ). Patients with nodular-HT ( n =1593) had high titer TAb and/or hypothyroidism. nodular goiter (NG) were subdivided TAb−NG =8812) undetectable TAb+NG =3395) positive TAb. Among patients, those showed higher PTC (9.4%) compared both (6.4%;...
Objective To evaluate the risk of papillary thyroid carcinoma (PTC) at fine-needle aspiration (FNA) cytology in 34 120 patients. Results False positive and false negative rates FNA were 1.2 1.8% comparison with histology 3406 nodules from 3004 patients who underwent surgery. PTC (901 cases) was more frequent solitary nodule (SN; 446/13 549, 3.3%) than multinodular goiter (MNG; 411/19 923, 2%, χ 2 =48.8; P <0.0001), males (209/6382, females (648/26 945, 2.40%, =15.58; <0.0001)....
Iodine deficiency disorders are a major public health problem, and programs have been implemented to improve iodine nutrition. The objective of the study was verify effects voluntary prophylaxis in small rural community (Pescopagano, Italy). design evaluation prevalence thyroid 15 years after previous survey conducted before prophylaxis. setting for this general survey. One thousand one hundred forty-eight residents were examined 2010 1411 1995. In 2010, 757 1148 subjects (65.9%) routinely...
The mechanisms linking thyroid autoimmunity and iodine use in humans are unknown.Our aim was to correlate intake, autoimmunity, recognition of thyroglobulin (Tg) epitopes after implementation prophylaxis.The general community living an Italian village evaluated.Thyroglobulin autoantibodies (TgAb), thyroperoxidase (TPOAb), urinary excretion were assessed 906 iodized salt users (IS-users) 389 nonusers (IS-nonusers). Ultrasound (US) performed identify hypoechogenicity, suggestive Hashimoto...
Several studies have underlined the high prevalence of psychiatric symptoms and disorders in thyroid diseases. The aim this study was to evaluate 93 inpatients affected by different diseases during their lifetimes, means a standardized instrument, i.e., Structured Clinical Interview for Diagnostic Statistical Manual Mental Disorders-III-Revised, Upjohn Version (SCID-UP-R). results showed higher rates panic disorder, simple phobia, obsessive-compulsive major depressive bipolar disorder...
We investigated the interrelationship and influence of thyroid-stimulating antibodies (TSAb), TSH-blocking (TSHBAb), radioiodine (131I)-induced thyroid damage in early (within 1 yr) outcome function hyperthyroid patients with Graves’ disease (GD) treated 131I. TSAb, TSHBAb, ultrasound volume (as an index damage) were simultaneously measured before at 1, 3, 6, 12 months after 131I 31 GD patients. One year radioiodine, 9.7% (Hyper-group), requiring methimazole; 12.9% euthyroid (Eu-group);...
The risk of papillary thyroid cancer (PTC) is related to serum TSH, and the development autonomy by reducing TSH levels decreases frequency PTC in patients with nodular goiter. Our aim was investigate effect L-thyroxine (LT(4)) on diagnosed cytology a large series goiter untreated (n=20 055) or treated L-T(4) (n=7859). L-T(4)-treated respect presented significantly lower (median, interquartile range: 0.30 muU/ml, 0.08-0.62 microU/ml versus 0.70 0.38-1.14 muU/ml; P<0.0001) prevalence (3.2 vs...
This review focuses on two different topics: (a) iodine and autoimmune thyroid disease (AITD) (b) AITD papillary carcinoma (PTC). Iodine intake modifies the expression of diseases has been associated with induction AITD. Thyroglobulin (Tg) is an important target in iodine-induced response due to post-translational modifications iodinated Tg, as suggested animal models. We have shown that unmasking a cryptic epitope Tg contributes autoimmunity humans. The relationship between PTC many...
Toxic multinodular goiter is a cause of nonautoimmune hyperthyroidism and believed to differ in its nature pathogenesis from toxic adenoma. Gain-of-function mutations the TSH receptor gene have been identified as The at molecular level hyperfunctioning nodules has yet not reported.
Women with breast cancer (BC) and antithyroid peroxidase (TPO) autoantibodies (TPOAb) have a better prognosis than women lacking TPOAb. Sera from TPOAb displayed immunoreactivity to BC tissue by immunofluorescence that was not apparent in without We hypothesize BC/thyroid shared antigen provides target for humoral or cell-mediated immune activity; candidates include the sodium/iodide symporter (expressed thyroid BC), cross-reacting epitopes TPO lactoperoxidase (LPO) itself. As association is...
Activating thyrotropin (TSH) receptor mutations have been found in toxic adenomas and hot nodules contained multinodular goiter. The typical feature of goiter is the heterogeneity morphology function different follicles within same enlarged gland. In this report we describe a patient with huge goiter, normal free triiodothyronine (FT3) thyroxine (FT4) serum values, subnormal TSH concentration. Thyroid scintiscan showed two areas corresponding to basal apical left lobe. right lobe was poorly...
Stimulating thyrotropin receptor (TSHr) autoantibodies (TSAb) are the cause of hyperthyroidism in Graves' disease. In a patient's serum, TSAb can coexist with antagonist TSHr that block stimulatory activity (TSBAb); both vary amount and time. The objective study was to create functional assay detects only TSAb, thus having an increased accuracy for diagnosing A chimera (Mc4) retains agonist-sensitive epitope but replaces TSBAb stably transfected cells establish Mc4 assay. conducted at Chieti...
To assess the distribution of clinical features and metabolic abnormalities polycystic ovary syndrome (PCOS) women according to their age.Retrospective study on 602 (mean age 23.9 ± 6.2 years), diagnosed International PCOS Network Guidelines criteria as having in a University-based Hospital. Anthropometric features, hormonal parameters were measured compared between different groups (group A ≤ 20 years; group B 21-30 C > 30 years).Patients more often hyperandrogenic, while hypertension,...