A5012211239- Neuroendocrine Tumor Research Advances
- Neuroblastoma Research and Treatments
- Lung Cancer Research Studies
- Epigenetics and DNA Methylation
- Lung Cancer Treatments and Mutations
- Uterine Myomas and Treatments
- Bladder and Urothelial Cancer Treatments
- Sarcoma Diagnosis and Treatment
- Urinary and Genital Oncology Studies
- Peptidase Inhibition and Analysis
- Cancer-related molecular mechanisms research
- Pancreatic and Hepatic Oncology Research
- Fibroblast Growth Factor Research
- DNA Repair Mechanisms
- Adrenal and Paraganglionic Tumors
- Congenital heart defects research
- Genetic factors in colorectal cancer
- Genetic and Kidney Cyst Diseases
- Breast Lesions and Carcinomas
- Oral health in cancer treatment
- Reproductive System and Pregnancy
- Management of metastatic bone disease
- Cancer survivorship and care
- Cancer Immunotherapy and Biomarkers
- Endometrial and Cervical Cancer Treatments
Technical University of Munich
2024-2025
Juntendo University
2020-2024
Fukuoka University
2023
Juntendo University Nerima Hospital
2018
Abstract Background Currently, only limited knowledge is available regarding the phenotypic association between fibroblast growth factor receptor 3 (FGFR3) alterations and tumor microenvironment (TME) in bladder cancer (BLCA). Methods A multi-omics analysis on 389 BLCA 35 adjacent normal tissues from a cohort of OMPU-NCC Consortium Japan was retrospectively performed by integrating whole-exome RNA-sequence dataset clinicopathological record. median follow-up duration all 31 months. Results...
Abstract Little is known about the morphomolecular features of G3 neuroendocrine tumors (G3NETs) under prolonged systemic treatments, although rapid progression increasingly observed. This longitudinal study aims to elucidate course and metastasized G3NETs with high-grade transformation. Clinical histological findings in 40 patients treated G3NETs, which were histologically examined at least twice an interval time more than 6 months (median 27), reviewed changes recorded assigned treatment....
Many pancreatic neuroendocrine tumors (PanNETs) fall into 2 major prognostic subtypes based on DAXX/ATRX-induced alternative lengthening of telomerase phenotype and alpha- beta-cell-like epigenomic profiles. However, these PanNETs are still flanked by other that do not fit either subtype. Furthermore, despite advanced genotyping, generally well-characterized in terms their histologic hormonal phenotypes. We aimed to identify new subgroups extending the currently used transcription factor...
Subtypes of small cell lung carcinoma (SCLC) are defined by the expression ASCL1, NEUROD1, and POU2F3 markers. The aim our study was to explore extent which intratumoral heterogeneity may lead discrepancies in these markers surgical samples their matched tissue microarray (TMA) lymph node (LN) metastatic sites. METHODS AND RESULTS: cohort included 77 patients with SCLC. Immunohistochemical examinations were performed on whole slides primary tumour, paired TMAs, LN Samples H-scores >50...
Chemoradiation therapy (CRT) has been increasingly reported as a possible alternative to total cystectomy (TC) for localized bladder cancer (BC). Pembrolizumab is the standard of care platinum-refractory metastatic urothelial carcinoma, although it unknown whether efficacy pembrolizumab in patients previously treated with curative CRT varies from results benchmark trials.We retrospectively assessed survival benefit differs between TC or radical treatment. A 212 patient records were collected...
Mesonephric-like adenocarcinoma is a rare neoplasm of the uterine corpus and ovary. Unlike prototypical mesonephric cervix, which considered Wolffian origin, recent evidence suggests that mesonephric-like Mullerian tumor associated with endometriosis. We report here on 48-year-old woman mixed carcinoma ovary consisted adenocarcinoma, clear cell carcinoma, endometrioid arising from an endometriotic cyst. The cuboidal cells vesicular nuclei presenting tubular, ductal, papillary, solid...
ObjectiveThis study aims to elucidate the trajectory of quality life (QoL) over a two-year period after radiotherapy and/or chemotherapy for head and neck cancer (HNC), addressing gap in long-term QoL information.MethodsEmploying prospective longitudinal observational design, we tracked 58 HNC patients who underwent chemotherapy, analyzing their using SF36v2, EORTC-QLQ-C30, EORTC-QLQ-H&N35 questionnaires two years post-discharge. Data repeated measures analysis variance.ResultsOver...
Pancreatic neuroendocrine tumors (PanNETs) show pronounced heterogeneity in terms of hormone and transcription factor (TF) expression. TFs such as ARX PDX1 are related to alpha- beta-cell-type features, respectively, partly associate with patient outcome. However, detailed studies correlating expression, histology, clinical data lacking. The aim this study was identify subtypes PanNETs that histological, hormonal, prognostic findings. A total 185 resected were divided into five (types A1,...
We report here an extremely rare case of hepatic sclerosing hemangioma mimicking a biliary cystadenocarcinoma. A previously healthy 39-year-old woman was referred to our hospital because large tumor in the liver. Abdominal computed tomography revealed early peripheral ring enhancement arterial phase and slight internal heterogeneous delayed phase. Magnetic resonance imaging with low intensity T1-weighted image very high fat-saturated T2-weighted image. The patient underwent hepatectomy for...
Cervical leiomyosarcoma is known to be rare from the previous reviews of a large number malignant cervical tumors. The patient was 66-year-old woman with irregular vaginal bleeding. She underwent modified radical hysterectomy and bilateral salpingooophorectomy. Histopathologically, we diagnosed coexistence uterine gastric-type adenocarcinoma in situ endometrial lesions that had continuous skip patterns fallopian tubal partial lesion. To best our knowledge, cases synchronous cancers have not...
Abstract A limited number of patients with lung squamous cell carcinoma (SCC) benefit clinically from molecular targeted drugs because a lack targetable driver alterations. We aimed to understand the prevalence and clinical significance lysine‐specific demethylase 5D ( KDM5D ) copy loss in SCC explore its potential as predictive biomarker for ataxia‐telangiectasia Rad3‐related (ATR) inhibitor treatment. evaluated 173 surgically resected SCCs male using fluorescence situ hybridization. was...
Abstract NTRK fusions have been reported to be rare in cancers across various organs, except for certain types of tumors. fusion positive tumors are highly sensitive TRK inhibitors such as Larotrectinib and Entrectinib. It is very important identify patients who may benefit from these inhibitors. In central nerve system (CNS) tumors, especially gliomas, the frequency has approximately 2%, however, CNS Japanese unknown. Pan-trk IHC useful physiological expression trks neural tissues hamper...
Aims: The reproducibility of Ki-67 between core-needle biopsies and surgical materials has not been well documented in the literature, although concordance affects utility labeling index based on biopsy materials, which indicates need for preoperative chemotherapy. aim this study was to reveal both cause discrepancies. Methods Results: We analyzed 137 cases invasive carcinoma breast compared Ki-67-labeling materials. specimens ranged from 1% 85% (median: 13%) 80% 12%), respectively....
A distinct subset of lung adenocarcinomas (LADs), arising from a series peripheral cells defined as the terminal respiratory unit (TRU), is characterised by thyroid transcription factor 1 (TTF-1) expression. The clinical relevance factors (TFs) other than TTF-1 remains unknown in LAD and was explored present study.Seventy-one samples were subjected to high-throughput transcriptome screening using cap analysis gene expression (CAGE) sequencing data; CAGE provides genome-wide levels start...