A5005441695- Spanish Linguistics and Language Studies
- Colorectal Cancer Surgical Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Epigenetics and DNA Methylation
- Linguistic Studies and Language Acquisition
- Cancer Genomics and Diagnostics
- Colorectal and Anal Carcinomas
- Colorectal Cancer Screening and Detection
- Diverticular Disease and Complications
- Gastrointestinal disorders and treatments
- Ferroptosis and cancer prognosis
- Anorectal Disease Treatments and Outcomes
- Surgical Simulation and Training
- Appendicitis Diagnosis and Management
- COVID-19 and healthcare impacts
- Global Health and Surgery
- Extracellular vesicles in disease
- Gastric Cancer Management and Outcomes
- Historical Linguistics and Language Studies
- Cancer-related molecular mechanisms research
- Literacy and Educational Practices
- Cultural and political discourse analysis
- Hernia repair and management
- linguistics and terminology studies
- Biliary and Gastrointestinal Fistulas
Instituto de Investigación Sanitaria del Principado de Asturias
2020-2025
University of Córdoba
2025
Witten/Herdecke University
2024
Central University Hospital of Asturias
2015-2023
Universidad de Oviedo
1996-2023
Gobierno del Principado de Asturias
2021-2023
Hospital Rio Carrion
2023
Jackson Memorial Hospital
2021
University of Miami Health System
2021
Hospital San Agustin
2014-2018
Colorectal cancer (CRC) is the third leading cause of death and fourth most common in world. Colonoscopy sensitive test used for detection CRC; however, their procedure invasive expensive population mass screening. Currently, fecal occult blood has been widely as a screening tool CRC but displays low specificity. The lack rapid simple methods makes early diagnosis therapy monitoring difficult. Extracellular vesicles (EVs) have emerged novel source biomarkers due to contents proteins miRNAs....
Extracellular vesicles (EVs) are biological nanoparticles of great interest as novel sources biomarkers and drug delivery systems for personalized therapies. The research in the field clinical applications require rapid quantification. In this study, we have developed a lateral flow immunoassay (LFIA) system based on Fe3O4 nanozymes extracellular vesicle (EV) detection. Iron oxide superparamagnetic (Fe3O4 MNPs) been reported peroxidase-like mimetic competent colorimetric labels. capabilities...
During the COVID-19 pandemic, reagents for SARS-CoV-2 detection were scarce or sold at high prices, particularly in Latin America. In this study, a significant step towards self-sufficiency was achieved through development of an in-house extraction kit detecting from nasopharyngeal swab samples. The purity and concentration RNA extracted using compared to those obtained GeneJET Purification Kit (Thermo-Scientific®) as reference. applicability evaluated four samples positive by NGS sequencing...
New immunogens against emerging new virus variants are essential for controlling variants. A preclinical study in which a receptor-binding domain (RBD) trimer was designed silico with information from the Beta (B.1.351), Omicron (BA.5), and Wuhan 1 variant. three-dimensional model of RBD-trimer made, synthesis based on RBD S protein Omicron. For experimental trials, 63 BALB/c mice were immunized divided into three groups: control (n=15), adjuvant (n=33). 81% (13/16), 90% (9/10), 85% (6/7)...
Linitis Plastica (LP) is a rare condition characterized by diffuse infiltration of the submucosal and muscularis propria layers hollow organ malignant cells. Three patients underwent colonoscopy, which revealed rectal stenosis with preserved mucosa. CT MRI demonstrated circumferential thickening wall. Histopathological immunohistochemical analyses confirmed All three received chemotherapy but died due to disease progression. Symptoms LP are nonspecific. Rectal examination typically reveals...
Long noncoding RNAs (lncRNAs) are promising biomarkers for the noninvasive diagnosis of colorectal cancer, but detection cancer-associated changes in their expression levels is now restricted to use RT-qPCR. To extend clinical applicability these biomarkers, we developed an electrochemical platform, integrated by two different sandwich genosensors, relative quantification a lncRNA called colon cancer associated transcript-1 (CCAT1) with respect mRNA GAPDH as endogenous control. achieve...
Promoter hypermethylation of tumour suppressor genes is frequently observed during the malignant transformation colorectal cancer (CRC). However, whether this epigenetic mechanism functional in or a mere consequence carcinogenic process remains to be elucidated.In work, we performed an integrative multi-omic approach identify gene candidates with strong correlations between DNA methylation and expression human CRC samples set 8 colon cell lines. As proof concept, combined recent CRISPR-Cas9...
Abstract Background Laser hemorrhoidoplasty (LHP) has emerged as a novel, minimally invasive technique for managing symptomatic hemorrhoids, gaining popularity among clinicians. Despite its increasing adoption, significant variations exist in the application of LHP across different practices. Purpose The aim these recommendations was to spell out some basic principles and performing standard procedure. Methods Recommendation Development Group (RDG) consisting surgeons with experience were...
The aim of this study was to evaluate the feasibility, safety, perioperative morbidity, and short-term outcomes transanal minimally invasive surgery (TAMIS) technique.This is a descriptive review prospectively collected data from 32 consecutive patients who underwent TAMIS procedures in our colorectal unit over 40-month period. GelPOINT Path port used all cases. Demographic data, indications, tumor characteristics, follow-up were collected. Primary endpoints included resection...
Post-nephrectomy diaphragmatic hernia is an extremely rare condition. The symptoms may be acute or latent and will depend on the herniated organ, which makes it difficult to suspect. Therefore, necessary know about this type of iatrogenic avoid a delay in diagnosis. A radiological confirmation with computed tomography early surgical treatment greatly decreased morbidity mortality. We report two cases: 76-year-old male, who underwent right nephrectomy 18 days prior due renal carcinoma;...
To establish the association between lymph node involvement and response to neoadjuvant therapy in locally advanced rectal cancer.Data of 130 patients with mid low adenocarcinoma treated chemoradiation followed by radical surgery over a 5-year period were reviewed. Tumor staging was done endorectal ultrasound and/or magnetic resonance imaging. determined T-downstaging tumor regression grading (TRG). Pathologic complete (pCR) is defined as absence cells surgical specimen (ypT0N0). The varying...