A5034813638- Sleep and related disorders
- Sleep and Wakefulness Research
- Obstructive Sleep Apnea Research
- Epilepsy research and treatment
- Sleep and Work-Related Fatigue
- Neuroscience of respiration and sleep
- EEG and Brain-Computer Interfaces
- Restless Legs Syndrome Research
- Neuroscience and Neuropharmacology Research
- Circadian rhythm and melatonin
- Pharmacological Effects and Toxicity Studies
- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Advanced Neuroimaging Techniques and Applications
- Memory and Neural Mechanisms
- Non-Invasive Vital Sign Monitoring
- Neonatal and fetal brain pathology
- Functional Brain Connectivity Studies
- Transcranial Magnetic Stimulation Studies
- Workplace Health and Well-being
- Diet and metabolism studies
- Ergonomics and Musculoskeletal Disorders
- Genetics and Neurodevelopmental Disorders
- Vestibular and auditory disorders
- Neural dynamics and brain function
Samsung Medical Center
2016-2025
Sungkyunkwan University
2016-2025
National Hospital for Neurology and Neurosurgery
2025
University College London
2025
Korea University
2016-2023
Soonchunhyang University Hospital
2023
Samsung (South Korea)
2016-2020
Sungshin Women's University
2016-2019
Kyungpook National University
2013-2019
Catholic University of Korea
2019
To investigate differences in brain gray matter concentrations or volumes patients with obstructive sleep apnea syndrome (OSA) and healthy volunteers. Optimized voxel-based morphometry, an automated processing technique for MRI, was used to characterize structural newly diagnosed male patients. University hospital The study consisted of 36 OSA 31 non-apneic volunteers matched age (mean age, 44.8 years). Using the t-test, were identified. statistical significance level set a false discovery...
To investigate the structural changes in patients with chronic primary insomnia and relationships clinical features of insomnia. Statistical parametric mapping 8-based voxel-based morphometry was used to identify differences regional gray white matter between normal controls. University hospital. Twenty-seven 27 age/sex-matched Regional were compared using two-sample t-tests age, sex, intracranial volume as covariates. The a mean age 52.3 y had history 7.6 y. Patients displayed cognitive...
Despite compelling evidence from animal studies indicating hippocampal subfield-specific vulnerability to poor sleep quality and related cognitive impairment, there have been no human magnetic resonance imaging (MRI) investigating the relationship between subfield volume disturbance. Our aim was investigate pattern of changes across subfields in patients with primary insomnia relative controls.Pointwise morphometry allowed for measurements regions on T1-weighted MRI.University...
Obesity is a common disorder with many complications. Although chronodisruption plays role in obesity, few epidemiological studies have investigated the association between artificial light at night (ALAN) and obesity. Since sleep health related to both obesity ALAN, we outdoor ALAN after adjusting for health. We also This cross-sectional survey included 8526 adults, 39–70 years of age, who participated Korean Genome Epidemiology Study. Outdoor data were obtained from satellite images...
Differences in hippocampal volume (HV) were compared between chronic primary insomniacs (PIs) and good sleepers (GSs), the relationship HV memory function PIs was investigated to clarify effect of sleep deprivation on brain structure cognition.Twenty (mean age, 50 years; 18 females) 20 age-, gender-, education-matched GSs enrolled. Brain magnetic resonance imaging (MRI) performed a 1.5-T MRI scanner. Left right intracranial (ICV) measured manually. Nighttime polysomnography...
High-frequency oscillations (HFOs) represent a novel electrophysiologic marker of endogenous epileptogenicity. Clinically, this propensity can be utilized to more accurately delineate the resection margin before epilepsy surgery. Currently, prospective application HFOs is limited because lack an exact quantitative measure reliably identify HFO-generating areas necessary include in resection. Here, we evaluated potential patient-individualized approach identifying high-rate HFO regions plan...
To investigate differences in cortical thickness patients with obstructive sleep apnea (OSA) syndrome and healthy controls. Cortical was measured using a three-dimensional surface-based method that enabled more accurate measurement deep sulci localized regional mapping. University hospital. Thirty-eight male severe OSA (mean apnea-hypopnea index > 30/h) 36 age-matched controls were enrolled. obtained at 81,924 vertices across the entire brain by reconstructing inner outer surfaces an...
The present study was designed to investigate whether 24 h of SD negatively affects the attention and working memory increases serum concentrations stress hormones, glucose, inflammatory markers.The acute effects sleep deprivation (SD) on cognition hormones were evaluated in six healthy volunteers (all men, age 23-27 years). All good sleepers, had no history medical or neuropsychiatric diseases, not taking any kind medication. subjected Continuous Performance Test (CPT) for blood tests both...
Ketogenic diet (KD) is known to be effective in intractable epilepsy. However, the role of KD refractory status epilepticus (RSE) has not been well described. The aim this study explore patients with RSE. We retrospectively reviewed medical records four children and one adult RSE between October 2006 August 2010. All presented (SE) that was presumed associated viral encephalitis. After we failed control seizures standard measures for SE, tried KD. overall seizure frequency decreased <50%...
Abstract The prevalence of artificial light exposure has enabled us to be active any time the day or night, leading need for high alertness outside traditional daytime hours. To address this need, we developed a personalized sleep intervention framework that analyzes real-world sleep–wake patterns obtained from wearable devices maximize during specific target periods. Our utilizes mathematical model tracks dynamic pressure and circadian rhythm based on user’s history. In way, accurately...
To investigate changes in regional cerebral blood flow (rCBF) patients with obstructive sleep apnea-hypopnea syndrome (OSAHS). We compared the 99mTc-ethylcysteinate dimer (ECD) single photon emission computed tomography (SPECT) images of OSAHS those age- and sex-matched healthy volunteers. University hospital. Twenty-seven severe 27 volunteers underwent 99mTc-ECD brain SPECT studies. For statistical parametric mapping analysis, all were spatially normalized to standard template then smoothed...
Abstract Arousal during sleep can result in fragmentation and various physiological effects, impairing cognitive function raising blood pressure heart rate. However, the current definition of arousal has limitations assessing both amplitude duration, making it challenging to measure accurately. Moreover, there is inconsistency among inter-raters scoring, which renders susceptible subjective variability. Therefore, this study aims identify a highly accurate classifier for each stage by...
To localize cerebral perfusion differences during cataplexy, brain SPECT subtraction was performed between cataplexy and baseline awake period or REM sleep in patients with narcolepsy. During subtracted showed hyperperfusion right amygdala, bilateral cingulate gyri, basal ganglia, thalami, premotor cortices, sensorimotor insula, brainstem, hypoperfusion prefrontal cortex occipital lobe. This result suggests that is produced by the activation of amygdalo-cortico-basal ganglia-brainstem circuit.
To investigate postoperative changes in the cerebral glucose metabolism of patients with mesial temporal lobe epilepsy (MTLE), statistical parametric mapping (SPM) analysis was performed on pre- and 18F-fluorodeoxyglucose PET (FDG-PET) images. We included 28 MTLE who had undergone surgery been seizure-free postoperatively (16 left 12 right MTLE). All showed hippocampal sclerosis by pathology or brain MRI. FDG-PET images were reversed to lateralize epileptogenic zone side all patients....
Gray Matter Concentration Abnormality in Brains of Narcolepsy PatientsObjective: To investigate gray matter concentration changes the brains narcoleptic patients.Materials and Methods: Twenty-nine patient with cataplexy 29 age sex-matched normal subjects (mean age, 31 years old) underwent volumetric MRIs.The MRIs were spatially normalized to a standard T1 template subdivided into matter, white cerebrospinal fluid (CSF).These segmented images then smoothed using 12-mm full width at half...