Hepatocellular carcinoma (HCC) is one of the leading causes cancer death in world. It has been reported that HCC closely related to changes histone modifications. However, finding modification patterns key genes which still an important task. In our study, 11 kinds modifications promoter regions for different types were analyzed by hierarchical screening hepatocyte (normal) cell line and HepG2 (tumor) line. The their found. results indicate these may play a pivotal role occurrence HCC. By...

Abnormal histone modifications (HMs) can promote the occurrence of breast cancer. To elucidate relationship between HMs and gene expression, we analyzed HM binding patterns calculated their signal changes tumor cells normal cells. On this basis, influences on expression cancer-related genes were estimated by three different methods. The results showed that H3K79me2 H3K36me3 may contribute more to changes. Subsequently, 2109 with differential or levels during cancerogenesis identified Shannon...

The discovery of key epigenetic modifications in cancer is great significance for the study disease biomarkers. Through mining modification data relevant to cancer, some researches on are accumulating. In order make it easier integrate effects related cancers, we established CancerMHL (http://www.positionprediction.cn/), which provide DNA methylation, histone and lncRNAs as well effect these gene expression several cancers. To facilitate retrieval, offers flexible query options filters,...

// Lu-Qiang Zhang 1 and Qian-Zhong Li Laboratory of Theoretical Biophysics, School Physical Science Technology, Inner Mongolia University, Hohhot, China Correspondence to: Li, email: Keywords : transcription factors; histone modifications; DNase-I hypersensitivity; statistical redundancy; regulation mechanism Received December 15, 2016 Accepted March 11, 2017 Published April 09, Abstract Transcription factors modifications are vital for the gene expression. Hence, to estimate effects binding...

Breast cancer has a high mortality rate for females. Aberrant DNA methylation plays crucial role in the occurrence and progression of breast carcinoma. By comparing differences between tumor tissue normal tissue, we calculate analyze distributions hyper- hypomethylation sites different function regions. Results indicate that enhancer regions are often hypomethylated cancer. CpG islands (CGIs) mainly hypermethylated, while flanking CGI (shores shelves) is more easily hypomethylated. The gene...

Lung adenocarcinoma is one of the deadliest tumors. Studies have shown that N6-methyladenosine RNA methylation regulators, as a dynamic chemical modification, affect occurrence and development lung adenocarcinoma. To investigate relationship between mutations expression levels m6A regulators in adenocarcinoma, we investigated 38 regulators. We found regulatory factors did not changes levels, 19 differentially expressed genes were identified. All tumor samples classified into two subtypes...

Long non-coding RNAs (lncRNAs) play crucial roles in genetic markers, genome rearrangement, chromatin modifications, and other biological processes. Increasing evidence suggests that lncRNA functions are closely related to their subcellular localization. However, the distribution of lncRNAs different localizations is imbalanced. The number located nucleus more than ten times exosome.

Chronic myelogenous leukemia (CML) is a type of cancer with series characteristics that make it particularly suitable for observations on leukemogenesis. Research have exhibited the occurrence and progression CML are associated dynamic alterations histone modification (HM) patterns. In this study, we analyze distribution patterns 11 HM signals calculate signal changes these HMs in cell lines as compared normal lines. Meanwhile, impacts expression level CML-related genes investigated. Based...

Background: Current identification of chronic myelogenous leukemia markers tends to mine diagnostic or prognostic biomarkers, ignoring susceptibility in normal samples. Objective: We aim identify possible for preventing leukemia. Methods: Functional links H3K79me2 patterns and gene expression changes were inferred by correlation analyses. DNase-seq read distribution, transcription factor motifs, their binding data acquired via ceasBW HOMER. Normalized signals submitted a random forest...

Lung adenocarcinoma is a malignancy with low overall survival and poor prognosis. Studies have shown that lung progression relates to locus-specific/global changes in histone modifications. To explore the relationship between modification gene expression changes, we focused on 11 modifications quantitatively analyzed their influences expression. We found that, among studied modifications, H3K79me2 displayed greatest impact regulation. Based Shannon entropy, 867 genes differential levels...

In order to investigate the oncogenic mechanisms of lung adenocarcinoma (LUAD), hub genes can be identified by constructing co‑expression networks, and potential linkages between genes, transcription factors (TFs) microRNAs (miRNAs/miRs) visualized identified. present study, a total 12 co‑expressed modules were constructed, 9 these significantly correlated with clinical traits in LUAD. The differentially expressed miRNAs determined, targets miRNA from or TFs. results study demonstrated that...

Background: Epithelial-Mesenchymal Transition (EMT) and its reverse Mesenchymal- Epithelial (MET) are essential for tumor cells metastasis. However, the effect of epigenetic modifications on this transition is unclear. Objective: We aimed to explore key histone hub genes EMT/MET during Colorectal Cancer (CRC) Method: The differentially expressed modified were identified. Based modification features, up- down-regulated predicted by Random Forest algorithm. Through protein-protein interaction...

A class of proteins known as antifreeze (AFPs) appear in some organisms, allowing them to survive low-temperature environments. These AFPs irreversibly adsorb the surfaces ice crystals and reduce freezing temperature without significantly affecting equilibrium melting point. Ice crystal growth is inhibited gap between point non-equilibrium point, referred thermal hysteresis (TH). The irreversible adsorption on has been questioned because it not consistent with concentration dependence TH...