A5056198834- Electrical and Bioimpedance Tomography
- Sepsis Diagnosis and Treatment
- Blood Coagulation and Thrombosis Mechanisms
- Respiratory Support and Mechanisms
- Non-Invasive Vital Sign Monitoring
- S100 Proteins and Annexins
- Diabetes and associated disorders
- Diabetes Management and Research
- Acute Ischemic Stroke Management
- Parkinson's Disease Mechanisms and Treatments
- Pancreatic function and diabetes
- Neurotransmitter Receptor Influence on Behavior
- Inhalation and Respiratory Drug Delivery
- Thyroid and Parathyroid Surgery
- Neuroscience and Neuropharmacology Research
- Hemodynamic Monitoring and Therapy
- Trauma, Hemostasis, Coagulopathy, Resuscitation
Regionshospitalet Herning
2024
Steno Diabetes Centers
2024
University of Gothenburg
2009-2020
Integrative Research Laboratories
2020
University of Bradford
2020
Manchester Academic Health Science Centre
2020
University of Manchester
2020
Sahlgrenska University Hospital
2001-2011
Background: Treatment of type 1 diabetes mellitus (T1DM) has become increasingly technical with rapid developments in integration pumps and sensors to regulate insulin dosage, patient-initiated solutions as open-source automated delivery (OS-AID) systems, have gained popularity people diabetes. Studies shown increased glycemic control mental wellbeing users OS-AID systems. The aim this study was estimate the prevalence, effect on metabolic control, risk, everyday life for their parents...
Background: Electrical impedance tomography (EIT) is a non‐invasive technique that generates images of distribution. Changes in the pulmonary content air and blood are major determinants thoracic impedance. This study was designed to evaluate EIT monitoring perfusion wide range cardiac output. Methods: Eight anaesthetised, mechanically ventilated pigs were fitted with 16‐electrode belt at mid‐thoracic level generate analysed determine pulse‐synchronous systolic changes (Δ Z sys ). Stroke...
The heterogeneity of pulmonary ventilation (V), perfusion (Q) and V/Q matching impairs gas exchange in an acute lung injury (ALI). This study investigated the feasibility electrical impedance tomography (EIT) to assess distribution during endotoxinaemic ALI pigs.Mechanically ventilated, anaesthetised pigs (n=11, weight 30-36 kg) were studied infusion endotoxin for 150 min. Impedance changes related (Z(V)) (Z(Q)) monitored globally bilaterally four regions interest (ROIs) EIT image. ratio...
Here we describe for the first time distinctive pharmacological profile (3S)-3-(2,3-difluorophenyl)-3-methoxypyrrolidine (IRL752), a new phenyl-pyrrolidine derivative with regioselective central nervous system transmission-enhancing properties. IRL752 (3.7-150 µmol/kg, s.c.) was characterized through extensive in vivo studies using behavioral, tissue neurochemical, and gene expression as well microdialysis methods. Behaviorally, compound normalized tetrabenazine-induced hypoactivity, whereas...
Background: Tissue‐type plasminogen activator (tPA) is a key mediator of fibrinolysis. Matching pulmonary perfusion and ventilation critical denominator oxygenation in acute lung injury (ALI). This study investigates venoarterial plasma tPA gradients association with ALI induced by bronchoalveolar lavage (BAL) endotoxinemia (ETX). Methods: Twenty‐one anaesthetized, ventilated pigs were allocated to control (CTRL, n=5), saline (BAL, n=8) or infusion Escherichia coli endotoxin (ETX, n=8)....
Divergent regional filling characteristics of the lung may explain ventilator-induced injury. In this descriptive study, potential electrical impedance tomography (EIT) to determine progressive changes in during acute injury was explored.
Background: Microcirculatory dysfunction and formation of microthrombi are common in sepsis as a result procoagulant state. A profibrinolytic change has however, been reported early sepsis. This study investigates systemic regional (pulmonary, preportal, hepatic, renal) fibrinolytic capacity mirrored by fluxes tissue‐type plasminogen activator (t‐PA) response to acute endotoxemia volume resuscitation. Methods: Eight anaesthetized, ventilated pigs (24–29 kg) were instrumented for haemodynamic...