A5011962340- Muscle Physiology and Disorders
- Ubiquitin and proteasome pathways
- Mitochondrial Function and Pathology
- Genetics, Aging, and Longevity in Model Organisms
- Endoplasmic Reticulum Stress and Disease
- Genetic and rare skin diseases.
- Adipose Tissue and Metabolism
- Plant Stress Responses and Tolerance
- Plant tissue culture and regeneration
- Nitrogen and Sulfur Effects on Brassica
- South Asian Studies and Conflicts
- Exercise and Physiological Responses
- South Asian Studies and Diaspora
- Retinoids in leukemia and cellular processes
- ATP Synthase and ATPases Research
- Plant Genetic and Mutation Studies
- Indian History and Philosophy
- Climate change impacts on agriculture
- Spectroscopy and Chemometric Analyses
- Surgical site infection prevention
- Diverticular Disease and Complications
- Sharing Economy and Platforms
- Syphilis Diagnosis and Treatment
- Food Science and Nutritional Studies
- Edible Oils Quality and Analysis
St. Jude Children's Research Hospital
2015-2025
Pokhara University
2024
Macquarie University
2024
Indian Institute of Science Bangalore
2013-2021
All India Institute of Medical Sciences
2016-2018
All India Institute of Medical Sciences Bhopal
2018
All India Institute of Medical Sciences Raipur
2018
Central Soil Salinity Research Institute
2014
Santosh University
2013
The University of Texas Medical Branch at Galveston
2006
Abstract Decline in skeletal muscle cell size (myofiber atrophy) is a key feature of cancer-induced wasting (cachexia). In particular, atrophy the diaphragm, major responsible for breathing, an important determinant cancer-associated mortality. However, therapeutic options are limited. Here, we have used Drosophila transgenic screening to identify muscle-secreted factors (myokines) that act as paracrine regulators myofiber growth. Subsequent testing mouse myotubes revealed Fibcd1...
Defects in protein quality control are the underlying cause of age-related diseases. The western blot analysis detergent-soluble and insoluble fractions has proven useful identifying interventions that regulate proteostasis. Here, we describe protocol for such analyses Drosophila tissues, mouse skeletal muscle, human organoids, HEK293 cells. We key adaptations this provide information will help modify future studies other tissues disease models. For complete details on use execution...
Abstract This investigation was undertaken to compare the level of salinity tolerance newly bred CSR‐30 basmati rice variety with that sensitive HBC‐19 and Pokkali varieties. Twenty‐one‐day‐old hydroponically raised seedlings at 6 12 dS m −1 were investigated for growth, photosynthetic rate, chlorophyll content, ribulose‐1,5‐bisphosphate carboxylase‐oxygenase (Rubisco) activity, relative water content (RWC), membrane stability index (MSI), lipid peroxidation, Na/K ratio activities gene...
Mitochondrial biogenesis and morphological changes are associated with tissue specific functional demand, but the factors pathways that regulate these processes not completely identified. A lack of mitochondrial fusion has been implicated in various developmental pathological defects. The spatio-temporal regulation a tissue, such as muscle, is well understood. Here, we show Drosophila indirect flight muscles (IFMs) nuclear-encoded inner membrane gene, Opa1-like, regulated fashion by...
Calibration models were developed for Fourier Transform Near Infrared Reflectance spectroscopy using PLS method and coefficients of determination (r2) oil, protein, erucic acid crude fiber contents estimated 0.907, 0.922, 0.902, 0.903, respectively. Effects the salinity on these traits studied under normal saline environments in field (ECe 10.7dS·m-1) nethouse irrigation levels (ECiw 0, 9, 12, 15, 18 dS/m) during 2011–12 2012–13. At higher salinity; protein decreased by 7.27, 14.78, 34.25%...
MotivationEukaryotic cells have evolved complex functions via their compartmentalization into organelles and subcellular microenvironments. Such specialization of the cellular space enabled optimal function but also resulted in compartment-specific challenges to proteostasis. However, due paucity tools, how proteostasis is regulated physiological pathological conditions remains largely uncharted. In this study, we generated Drosophila strains that ubiquitously express misfolding-prone FlucDM...
We report a case of mucocutaneous Herpes Simplex Virus (HSV)-2 and Cytomegalovirus (CMV) infection in 39-year-old female with acquired immunodeficiency syndrome, who presented perigenital ulcer. The patient was receiving antiretroviral treatment (ART) for 3 months before presentation. Scraping from the ulcer positive HSV-2 Treponema pallidum using polymerase chain reactions (PCR). extent duration lesions led us to consider possibility coinfection CMV. also tested CMV by PCR. On subsequent...
Inflammatory linear verrucous epidermal nevus (ILVEN) is a rare form of which usually presents in childhood, mostly on the lower half body blaschkoid distribution. A wide variety topical, systemic, and surgical modalities have been tried for its treatment, but it known to be refractory treatment. We hereby are reporting case extensive systematized ILVEN showed moderate response treatment with acitretin topical calcipotriol.
This study investigated the distribution of fine root biomass and various soil properties in a grassland ecosystem within Bhadrapur Municipality, Nepal. Soil samples were systematically collected from randomly selected blocks undisturbed, disturbed, roadside areas during late rainy season. Analyses included texture, moisture content, temperature, pH, quantification (FRB; <5 mm diameter) top 15 cm depth. Results showed mean FRB was significantly higher undisturbed (7.77 t/ha) compared to...
Soil salinity is a constant problem that hinders crop productivity worldwide. The fast taking gargantuan proportions with population pressures on land, especially in developing countries. Availability of cultivable land soon going to be major these One the most appropriate courses action combat this engineer crops are salt tolerant. Genetic engineering should preferred over breeding as latter method time consuming. techniques becoming relatively easy and routine. genes for purpose also being...