A5009146596- Chromosomal and Genetic Variations
- CRISPR and Genetic Engineering
- RNA modifications and cancer
- Prenatal Screening and Diagnostics
- Respiratory and Cough-Related Research
- Plant Virus Research Studies
- Animal Genetics and Reproduction
- RNA and protein synthesis mechanisms
- Herpesvirus Infections and Treatments
- HIV Research and Treatment
- Genomics and Chromatin Dynamics
Columbia University Irving Medical Center
2024-2025
Cornell University
2020-2022
Cold Spring Harbor Laboratory
2020
Endogenous retroviruses are abundant components of mammalian genomes descended from ancient germline infections. In several mammals, the envelope proteins encoded by these elements protect against exogenous viruses, but this activity has not been documented with endogenously expressed envelopes in humans. We report that human genome harbors a large pool envelope-derived sequences potential to restrict retroviral infection. To test this, we characterized an protein, Suppressyn. found
Abstract Endogenous retroviruses are abundant components of mammalian genomes descended from ancient germline infections. In several mammals, the envelope proteins encoded by these elements protect against exogenous viruses, but this activity has not been documented in human. We report that our genome harbors a large pool envelope-derived sequences with potential to restrict retroviral infection. To further test this, we characterize detail protein, Suppressyn . found is expressed...
The human genome contains 24
ABSTRACT The human genome contains 24 gag -like capsid genes derived from deactivated retrotransposons conserved among eutherians. Although some of their encoded proteins retain the ability to form capsids and even transfer cargo, fitness benefit has remained elusive. Here we show that PNMA1 PNMA4 support reproductive capacity. Six-week-old mice lacking either Pnma1 or Pnma4 are indistinguishable wild-type littermates, but by six months mutant become prematurely subfertile, with precipitous...