A5103214954- Chromosomal and Genetic Variations
- CRISPR and Genetic Engineering
- Chemical Synthesis and Analysis
- Genomics and Chromatin Dynamics
- DNA and Nucleic Acid Chemistry
- Animal Genetics and Reproduction
- RNA and protein synthesis mechanisms
Yale University
2024-2025
Texas A&M University
1997
ABSTRACT The human genome contains 24 gag -like capsid genes derived from deactivated retrotransposons conserved among eutherians. Although some of their encoded proteins retain the ability to form capsids and even transfer cargo, fitness benefit has remained elusive. Here we show that PNMA1 PNMA4 support reproductive capacity. Six-week-old mice lacking either Pnma1 or Pnma4 are indistinguishable wild-type littermates, but by six months mutant become prematurely subfertile, with precipitous...
The human genome contains 24
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