A5018158235- Functional Brain Connectivity Studies
- vaccines and immunoinformatics approaches
- Sleep and Work-Related Fatigue
- Educational Games and Gamification
- Advanced Proteomics Techniques and Applications
- Treatment of Major Depression
- Tryptophan and brain disorders
- Bipolar Disorder and Treatment
- Trace Elements in Health
- Cognitive Abilities and Testing
- Memory and Neural Mechanisms
- Sleep and Wakefulness Research
- Genetic Neurodegenerative Diseases
- Schizophrenia research and treatment
- Intensive Care Unit Cognitive Disorders
- Circular RNAs in diseases
- Software Engineering Research
- Data Visualization and Analytics
- Peptidase Inhibition and Analysis
- Digital Games and Media
- Identity, Memory, and Therapy
- MicroRNA in disease regulation
- Monoclonal and Polyclonal Antibodies Research
- Neural and Behavioral Psychology Studies
- Electrolyte and hormonal disorders
Beijing Sport University
2024-2025
Jinan University
2019-2024
Abstract Background Previous studies have demonstrated structural and functional changes of the hippocampus in patients with major depressive disorder (MDD). However, no analyzed dynamic connectivity (dFC) hippocampal subregions melancholic MDD. We aimed to reveal patterns for dFC variability – including bilateral rostral caudal areas its associations cognitive impairment Methods Forty-two treatment-naive MDD features 55 demographically matched healthy controls were included. The...
ABSTRACT The neural compensation mechanism involves maintaining cognitive performance during sleep deprivation (SD) by triggering alternative activations. While task complexity modulates post‐SD activation, the role of SD duration remains uncertain. Thirty‐three healthy college students (16 male and 17 female) completed a 36‐h protocol, performing switching at baseline (pre‐SD), after 24 h (SD‐24), 36 (SD‐36). Resting‐state EEG signals were recorded for 5 min each stage analysed using...
The practice-based evidence suggests that it is possible to use eye movement desensitization and reprocessing (EMDR) treat major depressive disorder (MDD), but its specific efficacy unknown. A systematic search was carried out for randomized controlled trials comparing EMDR with a control condition group in MDD patients. Two meta-analyses were conducted, symptom reduction as primary outcome remission exploratory outcome. Eight studies 320 participants included this meta-analysis. first...
Abstract Here we proposed DeepImmu, a complete pipeline for neoantigen identification and validation that was based solely on mass spectrometry (MS) immunopeptidomics. In particular, new enrichment kit developed HLA peptide purification from small amount of biopsied tissue as low 18mg. To identify candidate neoantigens such sample, built DeepNovo Peptidome, highly sensitive de novo sequencing-based workflow identification. Furthermore, DeepSelf, personalized model immunogenicity prediction...
Abstract Neoantigens are promising targets for cancer immunotherapy but their discovery remains challenging, mainly due to the sensitivity of current technologies detect them and specificity our immune system recognize them. In this study, we addressed both those problems proposed a new approach neoantigen identification validation from mass spectrometry (MS) based immunopeptidomics. particular, developed DeepNovo Peptidome, de novo sequencing-based search engine that was optimized HLA...
Abstract BackgroundDepression is one of the most common psychiatric disease worldwide. Although research about pathogenesis depression have achieved progress, detailed effect non-coding RNAs (ncRNAs) in are still not clearly elucidated. This study was aimed to identify RNA biomarkers stress-induced via comprehensive analysis competing endogenous networkMethodsIn this present study, we acquired expression from seq profile three mice with depressive-like behaviors using chronic restraint...