A5100782143- Breast Cancer Treatment Studies
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Breast Implant and Reconstruction
- Cancer Cells and Metastasis
- Ferroptosis and cancer prognosis
- Genetic Mapping and Diversity in Plants and Animals
- Genetic and phenotypic traits in livestock
- DNA and Nucleic Acid Chemistry
- HER2/EGFR in Cancer Research
- Cancer Immunotherapy and Biomarkers
- Animal Nutrition and Physiology
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Retinoids in leukemia and cellular processes
- Cancer-related gene regulation
- Chronic Myeloid Leukemia Treatments
- Advanced biosensing and bioanalysis techniques
- Hippo pathway signaling and YAP/TAZ
- Gut microbiota and health
- Cancer-related Molecular Pathways
- Histone Deacetylase Inhibitors Research
- Advanced Breast Cancer Therapies
- Cytokine Signaling Pathways and Interactions
Chinese Academy of Agricultural Sciences
2024-2025
Institute of Animal Sciences
2024-2025
Henan University
2025
Hunan Provincial Center for Disease Control and Prevention
2023-2025
Xiangya Hospital Central South University
2017-2025
Central South University
2017-2025
Columbia University Irving Medical Center
2025
Institute of Animal Science
2024
The First People's Hospital of Changde
2022-2023
Second Xiangya Hospital of Central South University
2019-2022
CD44 is a single-pass cell surface glycoprotein that distinguished as the first molecule used to identify cancer stem cells in solid tumors based on its expression.In this regard, high population demonstrates not only ability regenerate heterogeneous tumor, but also self-regenerate when transplanted into immune-deficient mice.However, exact role of remains unclear part because exists various isoforms due alternative splicing.Methods: Gain-and loss-of-function methods different models were...
Breast cancer (BC) is the most common malignancy in women with unfavorite prognosis. Tanshinone IIA (Tan IIA) inhibits BC progression, however, underlying mechanism remains largely undefined. The cytotoxicity of Tan was assessed by CCK-8 and LDH assays. Ferroptosis monitored level MDA, Fe2+, lipid ROS GSH. IHC western blot were employed to detect localization expression SLC7A11, PIAS4, KDM1A other key molecules. SUMOylation SLC7A11 detected Ni-beads pull-down assay co-IP. Luciferase ChIP...
Cancer-associated fibroblasts (CAFs) have been identified to drive chemotherapy resistance in triple-negative breast cancer (TNBC). This study evaluated the functions of CAFs-mediated suppressive ferroptosis doxorubicin (DOX) TNBC and its detailed molecular mechanisms. cell lines were co-cultured with CAFs isolated from DOX-sensitive (CAF/S) or DOX-resistant (CAF/R) tissues. Cell viability death assessed by counting Kit-8 (CCK-8) propidium iodide (PI) staining. Ferroptosis was detection...
Abstract Background Wenchang chickens are one of the most popular local chicken breeds in Chinese industry. However, low feed efficiency is main shortcoming this breed. Therefore, there a need to find more precise breeding method improve chickens. In study, we explored important candidate genes and variants for growth traits through genome-wide association study (GWAS) analysis. Results Estimates genomic heritability traits, including residual intake (RFI) 0.05, average daily food (ADFI)...
Wenchang chicken is a native meat-type breed in Hainan Province, China, known for its tender meat, which high demand both domestically and internationally. Improving important economic traits of significant importance to the poultry market. In this study, we genotyped 3737 individuals from two generations using Jingxin No. 1 55K SNP chip, subsequently imputed chip data. After quality control, 41,086 high-quality SNPs were obtained. We performed weighted single-step genome-wide association...
Triple‑negative breast cancer (TNBC) is a subtype of with high degree malignancy. TNBC prone to distant metastasis and has poor prognosis. A number TNBC‑related microRNAs (miRNAs) have been studied identified. However, the detailed roles miR‑574‑5p in remain poorly understood. miR‑574‑5p, SRY (sex determining region Y)‑box 2 (SOX2), B‑cell lymphoma/leukaemia 11A (BCL11A), SKI like proto‑oncogene (SKIL) epithelial‑mesenchymal transition (EMT)‑related miRNAs proteins were measured by reverse...
Due to increased drug and radiation tolerance, there is an urgent need develop novel anticancer agents.In our previous study, we performed a series of structural modifications ursolic acid (UA), natural product pentacyclic triterpenes, found UA232, derivative with stronger anti-tumor activity.In vitro experiments showed that UA232 inhibited proliferation, induced G0/G1 arrest, promoted apoptosis in human breast cancer cervical cells.Mechanistic studies revealed protective autophagy via the...
The altered faecal metabolites and microbiota might be involved in the development of breast cancer. We aimed to investigate effect differential on proliferative activity cancer cells.We collected samples from 14 patients healthy subjects. Untargeted metabolomics analysis, short-chain fatty acid (SCFA) targeted 16S rDNA sequencing was performed. gut metabolite composition changed significantly. Levels norvaline, glucuronate galacturonate were lower group than Control (p < 0.05)....
Background/Aims: The bi-functional enzyme 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase-4 (PFKFB4) is highly expressed in many types of cancer and its requirement for tumor survival has been demonstrated glioma, lung, prostate cancers. However, whether PFKFB4 plays a role the metastasis remains uncertain. This study explores underlying mechanisms breast cells. Methods: expression was first analyzed using Cancer Genome Atlas (TCGA) dataset, confirmed by immunohistochemical staining...
Lapatinib, a tyrosine kinase inhibitor, can initially benefit the patients with breast tumors but fails in later treatment due to inevitable development of drug resistance. Estrogen-related receptor α (ERRα) modulates metabolic adaptations lapatinib-resistant cancer cells; however, underlying mechanism remains unclear. ERRα was predicted bind serine hydroxymethyltransferase 2 (SHMT2) transcription initiation site ER- and HER2-positive cell line BT-474; thus, we hypothesize that might...
Chemotherapy is one of the standard strategies for treatment breast cancer. Adriamycin (Dox) a first‐line chemotherapy agent However, gastrointestinal reactions, myocardial toxicity and other side effects caused by Dox due to its un‐specific cytotoxicity limit clinical effect. To address this need, aptamer has been regarded as an ideal target molecular carrier. In present study, we selected 5TR1 that can specifically bind MUC1 protein which important tumor biomarker, well potential in...
Abstract The current diagnostic technologies for assessing the axillary lymph node metastasis (ALNM) status accurately in breast cancer (BC) remain unsatisfactory. Here, we developed a model evaluating ALNM using combination of mRNAs and T stage primary tumor as novel biomarker. We collected relevant information on T1–2 BC from public databases. An prediction was by logistic regression based screened signatures then internally externally validated. Calibration curves area under curve (AUC)...
Background: Hypoxia is a common phenomenon in solid tumors, which plays an important role tumor proliferation, apoptosis, angiogenesis, invasion and metastasis, energy metabolism chemoradiotherapy resistance. However, comprehensive analysis of hypoxia markers colorectal adenocarcinoma (COAD) still lacking. And there need for mechanism exploration clinical application. Methods: The gene expression, mutation data COAD were downloaded from Cancer Genome Atlas (TCGA) the Gene Expression Omnibus...
Abstract Background Wenchang chickens are one of the most popular local chicken breeds in Chinese industry. However, low feed conversion efficiency is main shortcoming this breed. Therefore, we urgently need to find a more precise breeding method improve chickens. In study, explored important candidate genes and variants for growth traits by genome-wide association study (GWAS) analysis. Results Estimates genomic heritability traits, including residual intake (RFI), average daily food...
Abstract Background Controversy exists around the locoregional management of primary tumor for breast cancer associated with synchronous ipsilateral supraclavicular lymph node metastasis (sISLM) due to rarity disease and limited available data. This study aimed compare outcomes patients in Surveillance, Epidemiology, End Results (SEER) database sISLM who underwent surgical resection radiation those did not. Methods population‐based retrospective included without distant metastases from 2004...
Abstract The status of axillary lymph node metastases determines the treatment and overall survival breast cancer (BC) patients. Three-dimensional (3D) assessment methods have advantages for spatial localization are more responsive to morphological changes in nodes than two-dimensional (2D) methods, we speculate that developed using 3D reconstruction systems high diagnostic efficacy. This exploratory study included 43 patients with histologically confirmed BC diagnosed at Second Xiangya...
e12613 Background: The chemotherapy-free neoadjuvant regimens of dual HER2 blockade has showed encouraging rates pathological complete response (pCR) in patients with HER2-positive breast cancer. Additionally, combining cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors anti-HER2 therapy shown synergistic effects hormone receptor (HR)-positive However, there is limited data regarding this combination strategy HR-negative/HER2-positive settings. objective study was to evaluate the efficacy...