A5007388591- Cell Adhesion Molecules Research
- Tracheal and airway disorders
- Airway Management and Intubation Techniques
- Hippo pathway signaling and YAP/TAZ
- Neonatal Respiratory Health Research
- Wnt/β-catenin signaling in development and cancer
- HER2/EGFR in Cancer Research
- Extracellular vesicles in disease
- Transplantation: Methods and Outcomes
- Pancreatic and Hepatic Oncology Research
- Peptidase Inhibition and Analysis
- Respiratory Support and Mechanisms
- Organ Transplantation Techniques and Outcomes
- Erythrocyte Function and Pathophysiology
- Renal Transplantation Outcomes and Treatments
- Pancreatitis Pathology and Treatment
- Histone Deacetylase Inhibitors Research
- Mesenchymal stem cell research
- Cancer-related gene regulation
- Caveolin-1 and cellular processes
- RNA Research and Splicing
- Biomarkers in Disease Mechanisms
- Gas Sensing Nanomaterials and Sensors
- Biomedical Research and Pathophysiology
- Pancreatic function and diabetes
University of Turin
2015-2025
Istituto di Analisi dei Sistemi ed Informatica Antonio Ruberti
2022
Azienda Ospedaliera Citta' della Salute e della Scienza di Torino
2020
Rationale: When compared with VenturiMask after extubation, high-flow nasal oxygen provides physiological advantages. Objectives: To establish whether prevents endotracheal reintubation in hypoxemic patients VenturiMask. Methods: In this multicenter randomized trial, 494 exhibiting PaO2:FiO2 ratio ⩽ 300 mm Hg extubation were randomly assigned to receive or oxygen, the possibility apply rescue noninvasive ventilation before reintubation. High-flow use group was not permitted. Measurements and...
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease with limited therapeutic options. However, metabolic adaptation to the harsh PDAC environment can expose liabilities useful for therapy. Targeting key regulator mechanistic target of rapamycin complex 1 (mTORC1) and its downstream pathway shows efficacy only in subsets patients but gene modifiers maximising response remain be identified.Three independent cohorts were studied correlate PI3K-C2γ protein abundance outcome....
Abstract ErbB2 overexpression is detected in approximately 20% of breast cancers and correlated with poor survival. It was previously shown that the adaptor protein p130Cas/BCAR1 a crucial mediator transformation its confers invasive properties to ErbB2-positive human mammary epithelial cells. We herein prove, for first time, transcriptional repressor Blimp1 novel p130Cas/ErbB2-mediated invasiveness. Indeed, high expression levels are p130Cas/ErbB2 cells correlate metastatic status cancer...
p130 Crk-associated substrate (p130CAS; also known as BCAR1) is a scaffold protein that modulates many essential cellular processes such cell adhesion, proliferation, survival, migration, and intracellular signaling. p130Cas has been shown to be highly expressed in variety of human cancers epithelial origin. However, few data are available regarding the role during normal development homeostasis. To this end, we have generated genetically modified mouse which was specifically ablated...
// Brigitte Bisaro 1 , Marianna Sciortino Shana Colombo Maria Pilar Camacho Leal Andrea Costamagna Isabella Castellano 2 Filippo Montemurro 3 Valentina Rossi Giorgio Valabrega 4, Emilia Turco Paola Defilippi Sara Cabodi Department of Biotechnology and Health Sciences, University Torino, Italy Medical Investigative Clinical Oncology (INCO), Fondazione del Piemonte per l'Oncologia (FPO)-Candiolo Cancer Center (IRCCs), 4 Oncology, Correspondence to: Cabodi, e-mail: sara.cabodi@unito.it...
Acinar to ductal metaplasia is the prerequisite for initiation of Kras-driven pancreatic adenocarcinoma (PDAC), and candidate genes regulating this process are emerging from genome-wide association studies. The adaptor protein p130Cas emerged as a potential PDAC susceptibility gene Kras-synthetic lethal interactor in cell lines; however, its role development has remained largely unknown.Human samples murine KrasG12D-dependent cancer models increasing aggressiveness were used. was...
Cholesterol is a non-essential metabolite that exerts both structural and signaling functions. However, cholesterol biosynthesis elevated, actively supports, pancreatic carcinogenesis. Our previous work showed statins block the reprogramming of mutant KRAS-expressing acinar cells, spontaneously undergo metaplastic event termed acinar-to-ductal metaplasia (ADM) to initiate Here we tested impact supplementation on isolated primary wild-type cells observed enhanced ductal transdifferentiation,...
Abstract The ErbB2 receptor tyrosine kinase is overexpressed in approximately 15–20% of breast tumors and associated with aggressive disease poor clinical outcome. p130Cas represents a nodal scaffold protein regulating cell survival, migration proliferation normal pathological contexts. overexpression human cancer correlates prognosis metastasis formation. Recent data indicate that association to protects from degradation, thus enhancing tumorigenesis. Therefore, inhibiting p130Cas/ErbB2...
Ex vivo lung perfusion (EVLP) is a relevant procedure to increase the donor pool but could potentially airway tree ischemic injury risk.This study aimed evaluate direct effect of EVLP on by evaluating bronchial cell vitality and tissue signs series 117 rings collected from 40 conventional 19 EVLP-treated grafts. Bronchial related scraped epithelial cells were before surgical anastomosis.The preimplantation interval was significantly increased in graft group (p < 0.01). Conventional grafts...
Abstract Background Sepsis is a condition with high mortality and morbidity, characterized by deregulation of the immune response against pathogen. Current treatment strategies rely mainly on antibiotics supportive care. However, there growing interest in exploring cell-based therapies as complementary approaches. Human liver stem cells (HLSCs) are pluripotent mesenchymal origin, showing some advantages compared to terms immunomodulatory properties. HSLC-derived extracellular vesicles (EVs)...
Abstract Background Post-cardiotomy vasoplegic syndrome is a vasodilatory shock characterized by decrease of vascular tone with normal or increased cardiac output. A relative deficit in vasopressin secretion the postoperative was hypothesized. Copeptin secreted equimolar ratio but it more stable and easier to measure. The aim present study investigate whether perioperative copeptin associated post-cardiotomy syndrome. Methods All patients scheduled for surgery were evaluated. Exclusion...