A5054008707- HIV/AIDS Research and Interventions
- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- Adolescent Sexual and Reproductive Health
- HIV-related health complications and treatments
- HIV, Drug Use, Sexual Risk
- HIV/AIDS Impact and Responses
- Mobile Health and mHealth Applications
- Global Maternal and Child Health
- Crime Patterns and Interventions
- Adolescent and Pediatric Healthcare
- Homelessness and Social Issues
- Breastfeeding Practices and Influences
- Hepatitis C virus research
- Health Literacy and Information Accessibility
- Intimate Partner and Family Violence
- Hepatitis B Virus Studies
- Poverty, Education, and Child Welfare
- Tuberculosis Research and Epidemiology
- Vaccine Coverage and Hesitancy
- Community Health and Development
- Technology Use by Older Adults
- LGBTQ Health, Identity, and Policy
- Pneumonia and Respiratory Infections
- Focus Groups and Qualitative Methods
Gilead Sciences (United Kingdom)
2023-2025
Médecins Sans Frontières
2019-2024
University of Cape Town
2013-2023
Chelsea and Westminster Hospital
2023
Boston University
2016-2022
Faculty of Public Health
2020
University College Dublin
2015
BICSTaR (BICtegravir Single Tablet Regimen) is an ongoing, observational cohort study assessing the virologic effectiveness and safety of bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) in treatment-experienced (TE) treatment-naïve (TN) people with HIV across 14 countries over 24 months. We present 12-month outcomes from participants Japan cohort. Retrospective prospective data were pooled aged ≥20 years receiving B/F/TAF within routine clinical care Japan. Outcomes included...
Adequate antenatal care is important to both the health of a pregnant woman and her unborn baby. Given South Africa’s high rate cellphone penetration, mobile interventions have been touted as potentially powerful means disseminate information. This study aimed increase knowledge awareness by disseminating text messages about clinic procedures at visits, how be healthy during pregnancy. Participants recruited were women attending primary facility in Cape Town. A controlled clinical trial was...
Objective: Recycling tenofovir and lamivudine/emtricitabine (XTC) with dolutegravir would provide a more tolerable, affordable, scalable second-line regimen than an optimized nucleoside reverse transcriptase inhibitor (NRTI) backbone. We evaluated efficacy of tenofovir/lamivudine/dolutegravir (TLD) in patients failing first-line tenofovir/XTC/efavirenz or nevirapine. Design: Single arm, prospective, interventional study. Setting: Two primary care clinics Khayelitsha, South Africa....
VPUU has a wealth of experience to share and is engaged with broader national international policymakers implementing agencies. Researchers are grappling the difficulty providing rigorous project evaluation for these collaborations which could identify elements that work view their replication. This paper traces evolution an evidence-based approach violence prevention in Western Cape Province South Africa. The Violence Prevention through Urban Upgrading (VPUU) Town uses such approach, relies...
The use of mobile phones to deliver health care (mHealth) is increasing in popularity due the high prevalence phone penetration. This seen developing countries, where mHealth may be particularly useful overcoming traditional access barriers. Non-communicable diseases amenable interventions, and hypertension one with an escalating burden world.The objective this study was test whether dissemination information via a short message service (SMS) led improvements knowledge self-reported...
Abstract Background Real‐world evidence is an essential component of evidence‐based medicine. The aim the BICSTaR (BICtegravir Single Tablet Regimen) study to assess effectiveness and safety bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) in antiretroviral treatment‐naïve (TN) treatment‐experienced (TE) people with HIV. Methods a prospective, observational cohort study. Participants (≥18 years) are being followed for 24 months. A pooled analysis presented at 12 months, primary...
Background Globally, 37 million people are in need of lifelong antiretroviral treatment (ART). With the continual increase number living with HIV starting ART and for life-long retention adherence, increasing attention is being paid to differentiated service delivery (DSD), such as adherence clubs. Adherence clubs groups 25–30 stable patients who meet five times per year at their clinic or a community location facilitated by lay health-care worker distributes pre-packed ART. This qualitative...
At the time of writing, more than 17 million people have contracted COVID-19 globally and half a died.1Johns Hopkins University & MedicineCOVID-19 dashboard.https://coronavirus.jhu.edu/map.htmlDate accessed: July 29, 2020Google Scholar However, health impact is likely to be far substantial long-lasting in countries with high incidences tuberculosis HIV2Drain P Garrett N SARS-CoV-2 pandemic expanding sub-Saharan Africa: considerations for Covid-19 living HIV.EClinicalMedicine. 2020;...
The antiretroviral therapy (ART) adherence club (AC) model has supported clinically stable HIV patients' retention with group ART refills and psychosocial support. Reducing visit frequency by increasing to six months could further benefit patients unburden health systems. We conducted a pragmatic non-inferiority cluster randomized trial comparing standard of care (SoC) ACs six-month refill intervention in primary facility Khayelitsha, South Africa.Existing community-based facility-based were...
Recycling tenofovir and lamivudine/emtricitabine with dolutegravir (TLD) after failure of non-nucleoside transcriptase inhibitor first-line antiretroviral therapy is more tolerable scalable than plus optimized nucleoside reverse inhibitors. Studies have demonstrated TLD's efficacy as second line, but long-term follow-up limited.
Objective Longer intervals between routine clinic visits and medication refills are part of patient-centred, differentiated service delivery (DSD). They have been shown to improve patient outcomes as well optimise health services—vital ‘universal test-and-treat’ targets increase numbers HIV patients on antiretroviral treatment (ART). This qualitative study explored patient, healthcare worker key informant experiences perceptions extending ART 6 months in adherence clubs Khayelitsha, South...
Background BICSTaR is a multi-national, observational cohort evaluating the effectiveness, safety, and patient-reported outcomes (PROs) in treatment-naïve (TN) -experienced (TE) people with HIV-1 receiving bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) routine clinical care. We present 12-month (M12) of Italian cohort. Methods Participants initiating B/F/TAF care were prospectively followed. Outcomes included virological immunologic drug-related adverse events (DRAEs), treatment...
Youths in South Africa are poor utilizers of HIV health services. Medecins Sans Frontieres has been piloting youth-adapted services at a youth clinic Khayelitsha, including peer virtual mentorship program over mobile phones, piloted from March 2015 to May 2016.The objective this study was evaluate the effect on engagement with and explore acceptability both mentors mentees.Antiretroviral initiation, retention care (RIC), viral load suppression were compared between youths engaged two matched...
Daily oral pre-exposure prophylaxis (PrEP) is a key tool in addressing high HIV incidence among young women, and breaking the cycle of transmission. From 2017 to 2020, Médecins Sans Frontières (MSF) offered PrEP, conjunction with contraception risk-reduction counselling, women aged 18-25, government-run clinic Khayelitsha, low income prevalence area South Africa. Drawing on clinical, quantitative, qualitative interview data, we describe participants' experiences engagement PrEP program,...
Abstract Background & objectives The benefits of long-term adherence to antiretroviral therapy (ART) are countered by interruptions in care or disengagement from care. Healthcare workers (HCWs) play an important role patient engagement and negative authoritarian attitudes can drive patients disengage. However, little is known about HCWs’ perspectives on disengagement. We explored ART Khayelitsha, a peri-urban area South Africa with high HIV burden. Method Semi-structured interviews were...
Background Globally 68 million people are infected with lymphatic filariasis (LF), 17 of whom have lymphedema. This study explores the effects a lymphedema management program in Odisha State, India on morbidity and psychosocial associated Methodology/Principal Findings Focus groups were held patients (eight groups, separated by gender), their family members groups), community (four groups) volunteers who had participated for past three years. Significant social, physical, economic...
Introduction HIV self-testing (HIVST) offers a useful addition to testing services and enables individuals test privately. Despite recommendations the contrary, repeat is frequent among people already on anti-retroviral treatment (ART) there are concerns that oral might lead false negative results. A study was conducted in Khayelitsha, South Africa, assess feasibility uptake of HIVST linkage-to-care following HIVST. Methods Participants were recruited at two health facilities from 1 March...
Abstract Psychosocial challenges impact patients’ ability to remain on antiretroviral therapy lifelong, magnified by disorganized health-systems and healthcare worker (HCW) attitudes. To address this, Médecins Sans Frontières the Department of Health developed Welcome Service intervention, provide person-centered care at re-engagement after HIV treatment interruption. Implemented in Khayelitsha, South Africa, between August 2020 February 2021, intervention aimed reorganize triage, optimize...
Abstract Background The Post Natal Club (PNC) model assures comprehensive care, including HIV and Maternal Child Health for postpartum women living with their infants during an 18-month postnatal period. PNC was launched in 2016 Town Two Clinic, a primary health care facility Khayelitsha, South Africa. This qualitative research study aims to understand how participation PNCs affected knowledge transmission, peer support, behaviour change satisfaction the provided. Methods We conducted ten...
Background Despite the reduction of HIV mother-to-child transmission, there are concerns regarding transmission rate in breastfeeding period. We describe routine uptake 6 or 10 (6/10) weeks, 9 months and 18 testing, with without tracing, a cohort infants who received PCR testing at birth (birth PCR) (with point care (POC) testing) peri-urban primary health setting Khayelitsha, South Africa. Methods In this study conducted between November 2014 February 2018, HIV-positive mothers their...