A5057023226- FOXO transcription factor regulation
- Genetics, Aging, and Longevity in Model Organisms
- MicroRNA in disease regulation
- RNA Research and Splicing
- Genomics and Chromatin Dynamics
- RNA Interference and Gene Delivery
- Pluripotent Stem Cells Research
- Genomics, phytochemicals, and oxidative stress
- Pancreatic function and diabetes
Brown University
2017-2021
Abstract Neural stem cells (NSCs) in the adult and aged brain are largely quiescent, require transcriptional reprogramming to re‐enter cell cycle. However, mechanisms underlying these changes how they altered with age remain undefined. Here, we identify chromatin accessibility differences between primary neural stem/progenitor quiescent activated states. These distinct cellular states exhibit shared unique profiles, both associated gene regulation. Accessible specific activation or...
Glioblastoma (GBM) is an aggressive, age-associated malignant glioma that contains populations of cancer stem cells. These cells (GSCs) evade therapeutic interventions and repopulate tumors due to their existence in a slowly cycling quiescent state. Although aging well known increase initiation, the extent which mechanisms supporting GSC tumorigenicity are related physiological remains unknown. Here, we investigate transcriptional by Forkhead Box O3 (FOXO3), regulator promotes healthy aging,...
Abstract Adult neural stem cells are largely quiescent, and require transcriptional reprogramming to reenter the cell cycle undergo neurogenesis. However, precise mechanisms that underlie rapid overhaul during NSC activation remain undefined. Here, we identify genome-wide chromatin accessibility differences between primary progenitor in quiescent activated states. We show these distinct cellular states exhibit both shared unique profiles, which associated with gene regulation. Interestingly,...
Abstract FOXO transcription factors are critical for cellular homeostasis and have been implicated in longevity several species. Yet how these directly affect aging, particularly humans, is not well understood. Here, we take an integrated multi-omics approach to identify the chromatin-level mechanisms by which FOXO3 coordinates transcriptional programs. We find that functions as a pioneer factor human cells, altering chromatin accessibility regulate gene expression. Unexpectedly, FOXO3’s...