A5008928072- Ultrasound Imaging and Elastography
- Photoacoustic and Ultrasonic Imaging
- Ultrasound and Hyperthermia Applications
- Ultrasonics and Acoustic Wave Propagation
- Advanced MRI Techniques and Applications
- Ultrasound and Cavitation Phenomena
- Traumatic Brain Injury and Neurovascular Disturbances
- Electrical and Bioimpedance Tomography
- 3D Printing in Biomedical Research
- Flow Measurement and Analysis
- Nuclear Physics and Applications
- Drug-Induced Ocular Toxicity
- Hormonal and reproductive studies
- Virus-based gene therapy research
- Optical Imaging and Spectroscopy Techniques
- Glioma Diagnosis and Treatment
- Anesthesia and Neurotoxicity Research
- Wireless Power Transfer Systems
- Piezoelectric Actuators and Control
- Epilepsy research and treatment
- Medical Image Segmentation Techniques
- Neurotransmitter Receptor Influence on Behavior
- Wireless Body Area Networks
- Cytomegalovirus and herpesvirus research
- Educational Robotics and Engineering
Columbia University
2001-2025
Sogang University
2012-2022
University of Pavia
2019
University of Florence
2019
University of Trento
2019
KU Leuven
2019
New York Psychoanalytic Society and Institute
2008
New York State Psychiatric Institute
2008
Presbyterian Hospital
2008
New York Hospital Queens
2008
: Focused ultrasound (FUS) in combination with microbubbles has recently shown great promise facilitating blood-brain barrier (BBB) opening for drug delivery and immunotherapy Alzheimer's disease (AD). However, it is currently limited to systems integrated within the MRI suites or requiring post-surgical implants, thus restricting its widespread clinical adoption. In this pilot study, we investigate safety feasibility of a portable, non-invasive neuronavigation-guided FUS (NgFUS) system...
Passive acoustic mapping (PAM) provides the spatial information of energy emitted from microbubbles during focused ultrasound (FUS), which can be used for safety and efficacy monitoring blood-brain barrier (BBB) opening. In our previous work with a neuronavigation-guided FUS system, only part cavitation signal could monitored in real time due to computational burden although full-burst analysis is required detect transient stochastic activity. addition, resolution PAM limited small-aperture...
Background: Focused ultrasound (FUS)-mediated blood-brain barrier (BBB) opening is a noninvasive, safe and reversible technique for targeted drug delivery to the brain. Most preclinical systems developed perform monitor BBB are comprised of separate geometrically focused transducer passive cavitation detector (PCD) or imaging array. This study builds upon previous work from our group developing single phased array configuration simultaneous monitoring called theranostic (ThUS), leveraging...
Abstract Focused Ultrasound (FUS) paired with systemically-injected microbubbles (μB) is capable of transiently opening the blood–brain barrier (BBBO) for noninvasive and targeted drug delivery to brain. FUS-BBBO also modulating neuroimmune system, further qualifying its therapeutic potential neurodegenerative diseases like Alzheimer’s disease (AD). Natural aging AD impose significant strain on brain particularly BBB, modifying structure subsequently, functionality. The emerging focus...
Focused ultrasound (FUS) is an emerging noinvasive technique for neuromodulation in the central nervous system (CNS). To evaluate effects of FUS-induced neuromodulation, many studies used behavioral changes, functional magnetic resonance imaging (fMRI) or electroencephalography (EEG). However, readouts are often not easily mapped to specific brain activity, EEG has low spatial resolution limited surface and fMRI requires a large importable scanner that limits additional manipulations. In...
The characterization of microbubble activity has proven critical in assessing the safety and efficacy ultrasound-mediated blood-brain barrier (BBB) opening drug gene delivery. In this study, we build upon our previous work on theranostic ultrasound (ThUS)-mediated BBB (ThUS-BBBO) conduct for first time a comprehensive role cavitation ThUS-BBBO, as well its impact delivery with adeno-associated viruses (AAV). A repurposed imaging phased array was used throughout study to generate focused...
ABSTRACT Gene therapy for neurodegenerative diseases faces significant challenges due to the blood-brain barrier (BBB), which limits drug delivery central nervous system (CNS). While clinical trials Parkinson’s disease (PD) have progressed, administration of vectors expressing enzymatic or neurotrophic factor transgenes required extensive optimization method achieve potentially therapeutic levels transgene expression. Focused ultrasound (FUS) combined with microbubbles has emerged as a...
Plane wave imaging has been proven to provide transmit beams with a narrow and uniform beam width throughout the depth. The pattern, however, exhibits strong grating lobes that have be suppressed by tightly focused receive pattern. In this paper, we present conditions of lobe occurrence analyzing synthetic Based on analysis, threshold angle interval is presented completely eliminate problems when using uniformly distributed plane angles. However, requires very small (or, equivalently, too...
Abstract Background Focused ultrasound (FUS) in combination with microbubbles has recently shown great promise facilitating blood-brain barrier (BBB) opening for drug delivery and immunotherapy Alzheimer’s disease (AD). However, it is currently limited to systems integrated within the MRI suites or requiring post-surgical implants, thus restricting its widespread clinical adoption. In this pilot study, we investigate safety feasibility of a portable, non-invasive neuronavigation-guided FUS...
In medical ultrasound imaging, Signal-to-noise ratio (SNR) is an important factor for imaging quality. Coded excitation methods have been widely used such as Golay codes and Barker to achieve higher SNR without degradation of axial resolution. The improvement determined by code length. However, because conventional are limited specific known sequences, it only allowed select one the sequences imaging. this paper, we propose a new Barker-sequence-modulated (BMG) coded technique proposed BMG...
Synthetic transmit focusing (STF) methods using unfocused waves or plane (PWs) have recently been investigated extensively. However, STF PWs with a convex array (PWSTF-CA) has not rigorously studied for high-resolution sector imaging. In this paper, the authors suggest an analytical model accurate characterization of spatial beam patterns PWSTF-CA large range either uniformly non-uniformly distributed PW angles. On basis model, frame-based approach non-uniform angles is suggested to achieve...
In a 3-D medical ultrasound imaging system, matrix array probe with 2-D positioning of the elements allows high resolution images due to its capability two-dimensional dynamic focusing. However, hundreds (up thousands) in make fabrication transducers and cables challenging. this paper, achieve quality low hardware complexity, we introduce column-based micro-beamformer (CMB) which column is considered as sub-array then elevational lateral beamformings are sequentially conducted analog digital...
Focused ultrasound (FUS) and microbubbles facilitate blood-brain barrier opening (BBBO) noninvasively, transiently, safely for targeted drug delivery. Unlike state-of-the-art approaches, in this study, we demonstrate the first time simultaneous, bilateral BBBO non-human primates (NHPs) using acoustic holograms at caudate putamen structures. The simple low-cost system with a single-element FUS transducer 3-D printed hologram was guided by neuronavigation robotic arm. advantages of are...
There is increasing interest in the point-of-care US system using smart devices, such as a tablet PC and smartphone, due to their high accessibility portability. To meet this growing interest, our group recently has developed smartphone-based portable but it only provided B-mode imaging. In paper, we present realization of Color Doppler (C-mode) imaging on aforementioned provide functional information velocity blood flow. The consists probe smartphone. implement C-mode processing, redesign...
Although plane wave imaging (PWI) with multiple waves (PWs) steered at different angles enables ultrafast three-dimensional (3-D) ultrasonic imaging, there is still a challenging tradeoff between image quality and frame rate. To address this challenge, we recently proposed the aperiodic PWI (APWI) mathematical analysis simulation study. In paper, demonstrate feasibility of APWI evaluate performance phantom in vivo experiments.APWI concentric ring angle pattern (APWI-C) sunflower (APWI-S) are...
We present real-time cavitation monitoring and mapping in a clinical trial for blood-brain barrier (BBB) opening Alzheimer’s disease (AD) patients using neuronavigation-guided focused ultrasound (FUS) system. Six AD (N = 6, age 68.5 ± 9.5) were sonicated at the right prefrontal lobe with single-element FUS transducer (PNP 0.2 MPa, fc 0.25 MHz, pulse length 10 ms, PRF 2 Hz, duration min) microbubble administration (Definity). performed passive detection (PCD) hydrophone 4), acoustic (PAM)...
In this paper, four beamforming algorithms (i.e., interpolation and phase rotation with pre- post-filtering, IBF-PRE, IBF-POST, PRBF-PRE PRBF-POST, respectively) implemented on a high-performance graphics-processing unit (GPU) were presented. Each method was divided into two kernels consisting of various mid-processing blocks efficiently NVIDIA's Computer Unified Device Architecture (CUDA) platform (GeForce GTX560 Ti, NVIDIA, Santa Clara, CA, USA). To evaluate the performance each method,...
Three-dimensional plane wave imaging (PWI) with a 2-D array has been studied for ultrafast volumetric in medical ultrasound. Compared to PWI, 3-D PWI requires the transmission of an increased number waves (PWs) scan volume interest and achieve transmit dynamic focusing both lateral elevational directions. To reduce PW angles given angular range by mitigating grating lobe level, we propose two aperiodic patterns angles: concentric rings uniform radial interval well-known sunflower pattern....
The spatiotemporal accuracy of passive acoustic mapping (PAM) for monitoring in situ cavitation bubbles has not been assessed directly via optical means. Here, the are monitored from two image sequences obtained simultaneously with PAM and high-speed photography (HSP). temporal detecting nucleation spatial resolution localization compared those measured HSP. results show that a 20 μs. Mean differences locations HSP as small 10.0 30.5 μm along lateral axial directions, respectively.
High quality ultrasound imaging is required throughout entire depths for abdominal ultrasound. In general, sector scanning with a convex array transducer performed by using focused beam to obtain wide field-of-view. However, the conventional focusing (CF) method suffers from degraded spatial resolution except vicinity of focal depth due diffractive propagation Plane wave synthetic (PWSF) has been initially proposed linear give solution diffraction problem interrogating beam. this paper, our...
Although plane wave imaging (PWI) has been extensively employed for ultrafast ultrasound imaging, its potential sectorial B-mode with a convex array transducer not yet widely recognized. Recently, we reported an optimized PWI approach sector scanning that exploits the dynamic transmit focusing capability. In this paper, first report clinical applicability of abdominal ultrasonography by in vivo image and video evaluations compare it conventional (CF) diverging (DWI), which is another...
In medical ultrasound imaging, the frequency- and depth-dependent attenuation causes degradation in signal-to-noise ratio (SNR) quadrature demodulation (QDM). To improve SNR, adaptive dynamic QDM (ADQDM) method based on a 2nd-order autoregressive (AR) spectral estimation was previously proposed. However, due to its high computational requirements, it is challenging implement ADQDM real time. this paper, optimal realization of GPU-based imaging system presented. efficiently method, image...